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Chemical Structure| 3400-35-9 Chemical Structure| 3400-35-9

Structure of 3400-35-9

Chemical Structure| 3400-35-9

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Product Details of [ 3400-35-9 ]

CAS No. :3400-35-9
Formula : C9H11NO2
M.W : 165.19
SMILES Code : O=C(NC)C1=CC=CC=C1OC
MDL No. :MFCD01578285

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Application In Synthesis of [ 3400-35-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3400-35-9 ]

[ 3400-35-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 67-56-1 ]
  • [ 52833-63-3 ]
  • [ 3400-35-9 ]
YieldReaction ConditionsOperation in experiment
64% With potassium hydroxide; In dimethyl sulfoxide; at 20℃; for 16h; General procedure: A mixture of 2-fluorobenzamide (1a, 69.5 mg, 0.5 mmol), MeOH (ca. 32.0 mg, 1.0 mmol), KOH (56.0 mg, 1.0 mmol) and DMSO (2.0 mL) in a 25 mL screw-capped thick-walled Pyrex tube was stirred at room temperature for 16 h, and then water (10 mL) was added to the reaction mixture with stirring, and the mixture was extracted with ethyl acetate three times (3 * 10 mL). The combined organic phases were dried over Na2SO4 overnight. The filtered solution was concentrated under reduced pressure, and the crude residue was purified by column chromatography on silica gel with the use of petroleum ether/ethyl acetate/trimethylamine (gradient mixture ratio from 6:1:0.05 to 2:1:0.05 in volume) to afford 2aa as a white solid in 80% yield (60.7 mg).
  • 2
  • [ 67-56-1 ]
  • [ 6609-56-9 ]
  • [ 3400-35-9 ]
 

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