52833-63-3|2-Fluoro-n-methylbenzamide| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 52833-63-3 ] Purity: 95% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 52833-63-3 ]

CAS No. :	52833-63-3
Formula :	C₈H₈FNO
M.W :	153.15
SMILES Code :	O=C(NC)C1=CC=CC=C1F
MDL No. :	MFCD01214098
InChI Key :	NAGFMACWWJYORB-UHFFFAOYSA-N
Pubchem ID :	2425972

Safety of [ 52833-63-3 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P280-P305+P351+P338-P304+P340-P405-P501

Application In Synthesis of [ 52833-63-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 52833-63-3 ]

[ 52833-63-3 ] Synthesis Path-Downstream 1~42

1
[ 393-52-2 ]
[ 74-89-5 ]
[ 52833-63-3 ]

Yield	Reaction Conditions	Operation in experiment
91%		General procedure: A mixture of propylamine (0.885 g, 15.0 mmol), K2CO3 (2.070 g, 15.0 mmol) andCH3CN (25 mL) in a 100-mL round-bottomed flask was stirred at 70 C for a few minutes,and then 2-fluorobenzoyl chloride (1.585 g, 10.0 mmol) was added dropwise to the mixture(ca. 0.5 h). The obtained reaction mixture was heated for additional 4 h and then cooled toroom temperature, water (50 mL) was added and the mixture was extracted with ethyl acetate(3 × 50 mL). The combined organic phases were dried over MgSO4.The filtered solution wasconcentrated under reduced pressure, and the crude residue was purified by columnchromatography on silica gel with the use of petroleum ether/ethyl acetate (gradient mixtureratio from 20:1 to 4:1 in volume) to afford 1a as a pale yellow oil in 90% yield (1.635 g).1b ~ 1m were prepared in 2.0 mmol-scale of benzoyl chlorides.
	With triethylamine; In dichloromethane; water; at 0 - 20℃; for 1h;	General procedure: Triethylamine (15 mmol), 33.3% methylamine in water (20 mmol) were added tothe solution of acid chloride (10 mmol) in CH2Cl2 (20 mL) at 0C. The reactionmixture was stirred at room temperature for 1 h and monitored by TLC until thereaction was completed. Then water (50 mL) was added to the mixture and extractedwith CH2Cl2 (30 mL). The organic phase was dried over anhydrous Na2SO4 andconcentrated under reduced pressure. The residue can be purified by silica gel flashchromatography or recrystallization, and the corresponding benzamide products canbe obtained with a yield of 80-95%.

References: [1]Molecules,2019,vol. 24.
[2]Magnetic Resonance in Chemistry,1993,vol. 31,p. 836 - 840.
[3]Synthesis,2010,p. 4273 - 4281.
[4]CrystEngComm,2013,vol. 15,p. 3711 - 3733.
[5]Organic Letters,2016,vol. 18,p. 3638 - 3641.
[6]Organic Letters,2016,vol. 18,p. 5536 - 5539.
[7]Journal of Organic Chemistry,2019,vol. 84,p. 11823 - 11838.
[8]Chinese Chemical Letters,2022,vol. 33,p. 1541 - 1544.

2
[ 445-29-4 ]
[ 52833-63-3 ]

References: [1]Magnetic Resonance in Chemistry,1993,vol. 31,p. 836 - 840.
[2]Organic Letters,2016,vol. 18,p. 5536 - 5539.
[3]Angewandte Chemie - International Edition,2020,vol. 59,p. 15076 - 15080.
Angew. Chem.,.

3
[ 394-35-4 ]
[ 74-89-5 ]
[ 52833-63-3 ]

Yield	Reaction Conditions	Operation in experiment
		The other compounds of Example 3 were prepared by essentially the same procedure using the corresponding carboxamide and acyl hydrazide. Acetonitrile was used as solvent in the preparation of 3-2. Compound [3-19] was isolated as a byproduct in the synthesis of 3-18. The methyl amides were prepared from their corresponding methyl esters and [METHYLAMINE] using well established protocols. The other amides were conveniently prepared from commercially available carboxylic acids and amines using 1- (dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride as the reagent and published procedures. Preparation of the acyl hydrazides was described in Procedures 3A, 3B, 3C and 3D.

References: [1]Patent: WO2003/104207,2003,A2 .Location in patent: Page 54.

4
[ 52833-63-3 ]
[ 333-27-7 ]
C₉H₇F₄NO₃S [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 3405 - 3411.

5
[ 1285712-37-9 ]
[ 10544-63-5 ]
[ 52833-63-3 ]

References: [1]Synthesis,2010,p. 4273 - 4281.

6
[ 52833-63-3 ]
[ 2216-94-6 ]
[ 1285712-19-7 ]

References: [1]Synthesis,2010,p. 4273 - 4281.

7
[ 141-32-2 ]
[ 52833-63-3 ]
[ 1355020-63-1 ]

References: [1]Organic Letters,2012,vol. 14,p. 728 - 731.

8
[ 52833-63-3 ]
[ 140-88-5 ]
[ 1355020-62-0 ]

References: [1]Organic Letters,2012,vol. 14,p. 728 - 731.

9
[ 52833-63-3 ]
[ 446-51-5 ]

References: [1]Chemical Communications,2014,vol. 50,p. 11211 - 11213.

10
[ 98-51-1 ]
[ 52833-63-3 ]
N-(4-(tert-butyl)benzoyl)-2-fluoro-N-methylbenzamide [ No CAS ]

References: [1]Organic Letters,2016,vol. 18,p. 3638 - 3641.

11
[ 106-43-4 ]
[ 52833-63-3 ]
4-chloro-N-(2-fluorobenzoyl)-N-methylbenzamide [ No CAS ]

References: [1]Organic Letters,2016,vol. 18,p. 3638 - 3641.

12
[ 52833-63-3 ]
[ 108-88-3 ]
N-benzoyl-2-fluoro-N-methylbenzamide [ No CAS ]

References: [1]Organic Letters,2016,vol. 18,p. 3638 - 3641.

13
[ 104-93-8 ]
[ 52833-63-3 ]
2-fluoro-N-(4-methoxybenzoyl)-N-methylbenzamide [ No CAS ]