Alternatived Products of [ 34179-62-9 ]
Product Details of [ 34179-62-9 ]
| CAS No. : | 34179-62-9 |
MDL No. : | MFCD27991890 |
| Formula : |
C5H5N3S
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
139.18
|
Pubchem ID : | - |
| Synonyms : |
|
Safety of [ 34179-62-9 ]
| Signal Word: | |
Class: | |
| Precautionary Statements: | |
UN#: | |
| Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 34179-62-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 34179-62-9 ]
- 1
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[ 34179-62-9 ]
-
[ 625-95-6 ]
-
[ 1574587-72-6 ]
| Yield | Reaction Conditions | Operation in experiment |
| 85% |
With dodecacarbonyl-triangulo-triruthenium; caesium carbonate In 1-methyl-pyrrolidin-2-one at 140℃; for 12h; regioselective reaction; |
General procedure for the synthesis of 3a
General procedure: 6-Phenylthiazolo[3,2-b]-1,2,4-triazole 1a (0.5 mmol, 100.5 mg), iodobenzene 2a (0.7 mmol, 142.8 mg), Ru3(CO)12 (3 mol%), and Cs2CO3 (1.0 mmol) were stirred in 2 mL of NMP at 140 °C for 12 h. After completion of the reaction (monitored by TLC), the water (15 mL) was added. The aqueous solution was extracted with ethyl acetate (3 * 10 mL) and the combined extract was dried with anhydrous Na2SO4. The solvent was removed and the crude product was separated by column chromatography (eluted with petroleum ether/ethyl acetate = 8:1) to give a pure product of 3a (117.7 mg). |
- 2
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[ 34179-62-9 ]
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[ 107-58-4 ]
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[ 1613052-97-3 ]
| Yield | Reaction Conditions | Operation in experiment |
| 83% |
With oxygen; copper diacetate; palladium diacetate; In 1,4-dioxane; at 110℃; for 12h; |
General procedure: 6-methylthiazolo[3,2-b]-1,2,4-triazole 1a (0.5 mmol),n-butyl acrylate 2a (1 mmol), Pd(OAc)2(10 mol%) and Cu(OAc)2 (2 equiv) were stirred in 2 mL of dioxane equipped with oxygen bag for 12 h at 110 C. After completionof the reaction (monitored by TLC), the water (15 mL) was added. The aqueoussolution was extracted with ethyl acetate (3×10 mL) and the combined extractwas dried with anhydrous MgSO4. The solvent was removed and thecrude product was separated by column chromatography (eluted with petroleumether/ethyl acetate = 8:1) to give a pure sample of 3a. |
- 3
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[ 34179-62-9 ]
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[ 14752-66-0 ]
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[ 1632154-29-0 ]
| Yield | Reaction Conditions | Operation in experiment |
| 81% |
With copper diacetate; palladium diacetate; In 1,4-dioxane; diethylene glycol dimethyl ether; at 120℃; for 24h; |
General procedure: A reaction vessel was charged with thiazolo[3,2-b]-1,2,4-triazoles 1 (0.5 mmol), sodium arylsulfinates 2 (1 mmol),Pd(OAc)2 (5 mol%), Cu(OAc)2 (2 equiv), and dioxane-diglyme (1:2; 1 mL). The mixture was stirred at 120 C andmonitored by TLC. After the completion of the reaction, themixture was poured into H2O (10 mL), and extracted withEtOAc (3 × 10 mL). The combined extract was dried withanhyd MgSO4. The solvent was removed and the crudeproduct was separated by column chromatography (elutedwith petroleum ether-EtOAc) to give the desired products 3and 4. |
- 4
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[ 34179-62-9 ]
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[ 34176-08-4 ]
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[ 1574587-82-8 ]
| Yield | Reaction Conditions | Operation in experiment |
| 79% |
With copper diacetate; palladium diacetate In 1,4-dioxane; diethylene glycol dimethyl ether at 120℃; for 24h; regioselective reaction; |
General Procedure for the Synthesis of 3 and 4
General procedure: A reaction vessel was charged with thiazolo[3,2-b]-1,2,4-triazoles 1 (0.5 mmol), sodium arylsulfinates 2 (1 mmol),Pd(OAc)2 (5 mol%), Cu(OAc)2 (2 equiv), and dioxane-diglyme (1:2; 1 mL). The mixture was stirred at 120 °C andmonitored by TLC. After the completion of the reaction, themixture was poured into H2O (10 mL), and extracted withEtOAc (3 × 10 mL). The combined extract was dried withanhyd MgSO4. The solvent was removed and the crudeproduct was separated by column chromatography (elutedwith petroleum ether-EtOAc) to give the desired products 3and 4. |
Reference：
[1]Wang, Shaohua; Liu, Wenjie; Lin, Juan; Jiang, Yi; Zhang, Qi; Zhong, Yue
[Synlett, 2014, vol. 25, # 4, p. 586 - 590]
- 5
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[ 34179-62-9 ]
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[ 824-80-6 ]
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[ 1423121-04-3 ]
| Yield | Reaction Conditions | Operation in experiment |
| 78% |
With copper diacetate; palladium diacetate; In 1,4-dioxane; diethylene glycol dimethyl ether; at 120℃; for 24h; |
General procedure: A reaction vessel was charged with thiazolo[3,2-b]-1,2,4-triazoles 1 (0.5 mmol), sodium arylsulfinates 2 (1 mmol),Pd(OAc)2 (5 mol%), Cu(OAc)2 (2 equiv), and dioxane-diglyme (1:2; 1 mL). The mixture was stirred at 120 C andmonitored by TLC. After the completion of the reaction, themixture was poured into H2O (10 mL), and extracted withEtOAc (3 × 10 mL). The combined extract was dried withanhyd MgSO4. The solvent was removed and the crudeproduct was separated by column chromatography (elutedwith petroleum ether-EtOAc) to give the desired products 3and 4. |
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