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Chemistry
Heterocyclic Building Blocks
Benzofurans
5-Chloro-2,3-dihydrobenzofuran-2-carboxylic acid
Chemistry
Heterocyclic Building Blocks
Organic Building Blocks
Benzofurans
Chlorides Carboxylic Acids

[ CAS No. 34385-94-9 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 34385-94-9
Chemical Structure| 34385-94-9
Structure of 34385-94-9 * Storage: {[proInfo.prStorage]}
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COA NMR CNMR HPLC LC-MS

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SDS Specification
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Product Details of [ 34385-94-9 ]

CAS No. :34385-94-9 MDL No. :MFCD06753266
Formula : C9H7ClO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 198.60 Pubchem ID :-
Synonyms :

Safety of [ 34385-94-9 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 34385-94-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 34385-94-9 ]

[ 34385-94-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 10242-10-1 ]
  • [ 34385-94-9 ]
Reference： [1]Journal of Medicinal Chemistry,1984,vol. 27,p. 570 - 576
[2]Il Farmaco,1998,vol. 53,p. 764 - 772
  • 2
  • [ 1914-60-9 ]
  • [ 34385-94-9 ]
YieldReaction ConditionsOperation in experiment
With N-chloro-succinimide; In N,N-dimethyl-formamide; at 25 - 60℃; for 3h;Inert atmosphere; To a mixture of <strong>[1914-60-9]2,3-dihydrobenzofuran-2-carboxylic acid</strong> (1.0 g, 6.09 mmol) in DMF (10 mL) was added NCS (976 mg, 7.31 mmol) at 25 C, and the mixture was heated to 60 C for 3 h. The reaction mixture was adjusted to pH = 5-6 by addition of iN HC1, and EtOAc was added (10 mL). The layers were separated and the aqueous phase was extracted with EtOAc (3 x 5 mL). The combined organic phases were washed with brine (5 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to provide 5 -chloro-2,3 -dihydrobenzofuran-2-carboxylic acid.
Reference： [1]Patent: WO2019/32743,2019,A1 .Location in patent: Paragraph 0218; 0398
  • 3
  • [ 34385-94-9 ]
  • [ 177906-48-8 ]
  • trans-tert-butyl (4-(5-chloro-2,3-dihydrobenzofuran-2-carboxamido)cyclohexyl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
100% To a solution of 5-chloro-2,3-dihydrobenzofuran-2-carboxylic acid (0.050 g, 0.25 mmol, 1.0 equiv) in DMF (05 mL) was added DIPEA (0.2 mL, 0.75 mmol, 3.0 equiv) followed by the addition of HATU (0.190 g, 0.50 mmol, 2.0 equiv) and the resulting mixture was stirred for 30 min. Trans-tert-butyl (4-aminocyclohexyl)carbamate (0.200 g, 0.90 mmol, 1.0 equiv) was added and the reaction mixture was allowed to stir overnight at RT and the resulting precipitate was filtered off and washed with excess methanol to obtain trans-tert-butyl (4-(5-chloro-2,3-dihydrobenzofuran-2-carboxamido)cyclohexyl)carbamate (100 mg, quantitative yield) as an off-white solid. LCMS: 394 [M+H]+.
Reference： [1]Patent: US2019/177310,2019,A1 .Location in patent: Paragraph 2586; 2587

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