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[ CAS No. 34486-18-5 ]

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DV 2D 3D

3d Animation Molecule Structure of 34486-18-5

Chemical Structure| 34486-18-5

Chemical Structure| 34486-18-5

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Quality Control of [ 34486-18-5 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 34486-18-5 ]

CAS No. :	34486-18-5	MDL No. :	MFCD12026108
Formula :	C₇H₆F₃NO	Boiling Point :	149.8°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	-
M.W :	177.12 g/mol	Pubchem ID :	-
Synonyms :

Calculated chemistry of of [ 34486-18-5 ]

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.29
Num. rotatable bonds :	2
Num. H-bond acceptors :	5.0
Num. H-bond donors :	0.0
Molar Refractivity :	35.73
TPSA :	22.12 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.9 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.73
Log Po/w (XLOGP3) :	2.08
Log Po/w (WLOGP) :	3.26
Log Po/w (MLOGP) :	1.65
Log Po/w (SILICOS-IT) :	2.34
Consensus Log Po/w :	2.21

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.49
Solubility :	0.578 mg/ml ; 0.00326 mol/l
Class :	Soluble
Log S (Ali) :	-2.17
Solubility :	1.19 mg/ml ; 0.0067 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.04
Solubility :	0.163 mg/ml ; 0.00092 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.66

Safety of [ 34486-18-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 34486-18-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 34486-18-5 ]

[ 34486-18-5 ] Synthesis Path-Downstream 1~13

Yield	Reaction Conditions	Operation in experiment
	entspr. Halogenverb., entspr. Alkoholat;
	entspr. Chlorid, NaOCH3;
	entspr. 2-Chlorverb., Methanol;

analog Bsp. 11;

Yield	Reaction Conditions	Operation in experiment
	With pyridine; methyl nitrite; nitrogen(II) oxide at 24.84℃; In air; Irradiation;

3
[ 34486-18-5 ]
[ 420-37-1 ]
2-methoxy-6-trifluoromethyl-N-methylpyridinium tetrafluoroborate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
58%	With pyridine In dichloromethane at 20℃; for 23h;
	In toluene at 20℃; for 2h; Glovebox;	N-Methyl-3,5-difluoro-4-methoxypyridinuim Trifluoromethanesulfonate (59). General procedure: A 3 mL glass vial was equipped with a rubber septum and magnetic stir bar. The vial was brought into a glove box and charged with methyl trifluoromethylsulfonate (MeOTf, 51 µL, 0.46 mmol) by micropipette with polypropylene tip. The vial was sealed and removed from the glove box. A separate 3 mL vial was charged with substrate (68 mg, 0.46 mmol) and was dissolved in PhMe (0.5 mL). The solution of pyridine was added via syringe onto the sealed vial of MeOTf at room temperature. The vial which contained the pyridine was rinsed with PhMe (0.2 mL) and the rinse solution was injected into the reaction vial. The reaction vial was kept at room temperature and stirring was maintained at ca. 400-600 rpm. Over the course of the reaction (2 hr), a precipitate formed. At the end of the reaction, PhMe (2 mL) was added after which stirring was stopped. Any solid or oil was allowed to settle and the solvent was removed by glass pipette. The residue was then rinsed with several portions of hexanes to remove any unreacted starting materials, again removing the solvent by pipette. Residual solvent was then removed in vacuo to provide the title compound (53 mg, 37%).

Reference： [1]Topczewski, Joseph J.; Quinn, Daniel M. [Organic Letters, 2013, vol. 15, # 5, p. 1084 - 1087]
[2]Topczewski, Joseph J.; Lodge, Alexander M.; Yasapala, Sumana N.; Payne, Maurice K.; Keshavarzi, Pedrom M.; Quinn, Daniel M. [Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 21, p. 5786 - 5789]

4
[ 34486-18-5 ]
[ 1422453-70-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: pyridine / dichloromethane / 23 h / 20 °C 2: dimethylsulfoxide-d6 / 25 °C
	Multi-step reaction with 2 steps 1: pyridine / dichloromethane / 23 h / 20 °C 2: water-d2 / 25 °C

Reference： [1]Topczewski, Joseph J.; Quinn, Daniel M. [Organic Letters, 2013, vol. 15, # 5, p. 1084 - 1087]
[2]Topczewski, Joseph J.; Quinn, Daniel M. [Organic Letters, 2013, vol. 15, # 5, p. 1084 - 1087]

5
[ 34486-06-1 ]
[ 74-88-4 ]
[ 34486-18-5 ]

Yield	Reaction Conditions	Operation in experiment
59.8%	With silver (II) carbonate; In dichloromethane; for 24h;Darkness;	2-methoxy-6-ftrifluoromethyl)pyridine To a solution of <strong>[34486-06-1]6-(trifluoromethyl)pyridin-2-ol</strong> (10.0 g, 10.0 g, 61.3 mmol) in dichloromethane (3 ml/mmol, 184 ml) was added silver carbonate (22.8 g, 82.8 mmol, 3.75 mL) and iodomethane (87.0 g, 613 mmol, 38.2 mL) and stirred in the dark for 24 hours. The reaction mixture was then filtered through Celite and washed with dichloromethane. The filtrate was concentrated at 30 oC at 250 mbar, silica added and the residue was purified by chromatography eluting with 0-10percent ethyl acetate/hexane. Fractions containing product were combined to give 2-methoxy-6-(trifluoromethyl)pyridine (6.49 g, 36.6 mmol, 59.8percent yield). IHNMR (CDC13): delta 7.69 ft, J =8.1 Hz, IH) 7.25 (d, J=7.5 Hz, 1 H) 6.91 (d, J=8.6 Hz, 1 H) 3.98 (s, 3 H);
59.8%	With silver carbonate; In dichloromethane;	2-methoxy-6-(trifluoromethyl)pyridine To a solution of <strong>[34486-06-1]6-(trifluoromethyl)pyridin-2-ol</strong> (10.0 g, 10.0 g, 61.3 mmol) in dichloromethane (3 ml/mmol, 184 ml) was added silver carbonate (22.8 g, 82.8 mmol, 3.75 mL) and iodomethane (87.0 g, 613 mmol, 38.2 mL) and stirred in the dark for 24 hours. The reaction mixture was then filtered through Celite and washed with dichloromethane. The filtrate was concentrated at 30° C. at 250 mbar, silica added and the residue was purified by chromatography eluting with 0-10percent ethyl acetate/hexane. Fractions containing product were combined to give 2-methoxy-6-(trifluoromethyl)pyridine (6.49 g, 36.6 mmol, 59.8percent yield). 1H NMR (CDCl3): delta 7.69 (t, J=8.1 Hz, 1H) 7.25 (d, J=7.5 Hz, 1H) 6.91 (d, J=8.6 Hz, 1H) 3.98 (s, 3H);
17%	With silver carbonate; In dichloromethane; at 20℃; for 24h;Darkness;	The suspension of 6- (trifluoromethyl) pyridin-2-ol (430 mg, 2.64 mmol) , iodomethane (3.75 g, 26.4mmol) and Ag 2CO 3 (982 mg, 3.56 mmol) in CH 2Cl 2 (8 mL) was stirred at room temperature in dark for 24 hrs. After completed, the mixture was filtered and the solvent was evaporated in vacuo at 30 . The residue was purified by column chromatography (PE/EA = 5/1) to give the product (80 mg in 17percentyield) . 1H NMR (400 MHz, CDCl 3) delta 7.76 ?7.59 (m, 1H) , 7.24 (d, J = 7.3 Hz, 1H) , 6.91 (d, J = 8.4 Hz, 1H) , 3.98 (s, 3H) .

Reference： [1]Patent: WO2013/50421,2013,A1 .Location in patent: Page/Page column 59
[2]Patent: US2014/256546,2014,A1 .Location in patent: Page/Page column
[3]Patent: WO2018/103688,2018,A1 .Location in patent: Paragraph 0376; 0377

6
[ 34486-18-5 ]
[ 5419-55-6 ]
[ 1429874-11-2 ]

Yield	Reaction Conditions	Operation in experiment
59%	Stage #1: 2-methoxy-6-(trifluoromethyl)pyridine With n-butyllithium In diethyl ether; hexane at -78 - 20℃; for 0.583333h; Inert atmosphere; Stage #2: Triisopropyl borate In diethyl ether; hexane at -78 - 20℃; for 0.75h; Stage #3: With hydrogenchloride In diethyl ether; hexane; water	16 2-methoxy-6-f trifluoromethyl)-3-pyridyll boronic acid 2-methoxy-6-f trifluoromethyl)-3-pyridyll boronic acid To a solution of 2-methoxy-6-(trifluoromethyl)pyridine (1.0 g, 5.6 mmol) and in diethyl ether (1.2 mL/mmol, 6.8 mL) at -78 C under nitrogen was added nBuLi (2.5 mol/L) in hexanes (4.7 g, 17 mmol, 6.8 mL) over 5 min and allowed to warm up to room temperature over 30 minutes. Boric acid triisopropyl ester (2.1 g, 11 mmol, 2.6 mL) in diethyl ether (1.2 mL/mmol, 6.8 mL) was cooled to -78 C and [2-methoxy-6-(trifluoromethyl)-3-pyridyl]lithium was added to this solution over 15 minutes and then warmed up to room temperature over 30 mins. Hydrogen chloride (aqueous 25%>) (10 mL, 10 mmol) was added and the reaction mixture diluted with water and extracted twice with dichloromethane, passed through a phase separator and reduced under vacuum to give a yellow oil which solidified overnight. The reaction mixture was adsorbed onto silica and purified by chromatography on silica, eluting with 0-25% ethyl acetate/hexane. Fractions containing product were combined to give [2-methoxy-6-(trifluoromethyl)-3-pyridyl]boronic acid as a yellow solid (707 mg, 3.20 mmol, 59% yield). IHNMR (llvu941hl, CDC13): δ 8.29 (d, J=7.5 Hz, 1 H) 7.34 (d, J=7.5 Hz, 1 H) 5.92 (s, 2 H) 4.10 (s, 3 H);
3.8 g	Stage #1: 2-methoxy-6-(trifluoromethyl)pyridine With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere; Stage #2: Triisopropyl borate In tetrahydrofuran at -78 - 20℃;	43.3 Step 3: (2-methoxy-6- (trifluoromethyl) pyridin-3-yl) boronic acid (43-3) To the solution of 2-methoxy-6- (trifluoromethyl) pyridine (3.9 g, 22 mmol) in THF (80 mL) under nitrogen was added n-BuLi (11 mL, 26 mmol) at -78 dropwise and stirred at the same temperature for 30 mins. Then B (OiPr) 3 was added and stirred for 5 hrs while the temperature warmed to room temperature. Then 1N hydrochloride was added and stirred for 1 hr. The reaction was quenched with saturated NH 4Cl aqueous solution and the resulting mixture was extracted with ethyl acetate. The organic layers were washed with brine dried over Na 2SO 4, filtered and evaporated in vacuo to give the product (3.8 g) as yellow solid which was used directly for the next step without further purification.

Reference： [1]Current Patent Assignee: Syngenta (in: Sinochem Holdings); SINOCHEM HOLDINGS CORPORATION LTD - WO2013/50421, 2013, A1 Location in patent: Page/Page column 59; 60
[2]Current Patent Assignee: BEIGENE LTD.; BEIGNE - WO2018/103688, 2018, A1 Location in patent: Paragraph 0378; 0379

7
[ 34486-18-5 ]
[ 1429874-13-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: n-butyllithium / hexane; diethyl ether / 0.58 h / -78 - 20 °C / Inert atmosphere 1.2: 0.75 h / -78 - 20 °C 2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / <i>tert</i>-butyl alcohol / 0.83 h / 80 °C

Reference： [1]Current Patent Assignee: Syngenta (in: Sinochem Holdings); SINOCHEM HOLDINGS CORPORATION LTD - WO2013/50421, 2013, A1

8
[ 34486-18-5 ]
[ 1429874-14-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: n-butyllithium / hexane; diethyl ether / 0.58 h / -78 - 20 °C / Inert atmosphere 1.2: 0.75 h / -78 - 20 °C 2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / <i>tert</i>-butyl alcohol / 0.83 h / 80 °C 3.1: hydrogen bromide / water / 0.75 h / 40 °C / Microwave irradiation

Reference： [1]Current Patent Assignee: Syngenta (in: Sinochem Holdings); SINOCHEM HOLDINGS CORPORATION LTD - WO2013/50421, 2013, A1

9
[ 34486-18-5 ]
[ 1429874-15-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: n-butyllithium / hexane; diethyl ether / 0.58 h / -78 - 20 °C / Inert atmosphere 1.2: 0.75 h / -78 - 20 °C 2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / <i>tert</i>-butyl alcohol / 0.83 h / 80 °C 3.1: hydrogen bromide / water / 0.75 h / 40 °C / Microwave irradiation 4.1: potassium carbonate / 1,2-dimethoxyethane / 0.5 h / 75 °C

Reference： [1]Current Patent Assignee: Syngenta (in: Sinochem Holdings); SINOCHEM HOLDINGS CORPORATION LTD - WO2013/50421, 2013, A1

10
[ 34486-18-5 ]
[ 1429873-64-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: n-butyllithium / hexane; diethyl ether / 0.58 h / -78 - 20 °C / Inert atmosphere 1.2: 0.75 h / -78 - 20 °C 2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / <i>tert</i>-butyl alcohol / 0.83 h / 80 °C 3.1: hydrogen bromide / water / 0.75 h / 40 °C / Microwave irradiation 4.1: potassium carbonate / 1,2-dimethoxyethane / 0.5 h / 75 °C 5.1: morpholine / 1.5 h / 100 °C

Reference： [1]Current Patent Assignee: Syngenta (in: Sinochem Holdings); SINOCHEM HOLDINGS CORPORATION LTD - WO2013/50421, 2013, A1

11
[ 34486-18-5 ]
[ 5419-55-6 ]
[2-methoxy-6-(trifluoromethyl)-3-pyridyl]lithium [ No CAS ]
[ 1429874-11-2 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride In diethyl ether	16 [2-methoxy-6-(trifluoromethyl)-3-pyridyl]boronic acid [2-methoxy-6-(trifluoromethyl)-3-pyridyl]boronic acid To a solution of 2-methoxy-6-(trifluoromethyl)pyridine (1.0 g, 5.6 mmol) and in diethyl ether (1.2 mL/mmol, 6.8 mL) at -78 C under nitrogen was added nBuLi (2.5 mol/L) in hexanes (4.7 g, 17 mmol, 6.8 mL) over 5 min and allowed to warm up to room temperature over 30 minutes. Boric acid triisopropyl ester (2.1 g, 11 mmol, 2.6 mL) in diethyl ether (1.2 mL/mmol, 6.8 mL) was cooled to -78 C and [2-methoxy-6-(trifluoromethyl)-3-pyridyl]lithium was added to this solution over 15 minutes and then warmed up to room temperature over 30 mins. Hydrogen chloride (aqueous 25%) (10 mL, 10 mmol) was added and the reaction mixture diluted with water and extracted twice with dichloromethane, passed through a phase separator and reduced under vacuum to give a yellow oil which solidified overnight. The reaction mixture was adsorbed onto silica and purified by chromatography on silica, eluting with 0-25% ethyl acetate/hexane. Fractions containing product were combined to give [2-methoxy-6-(trifluoromethyl)-3-pyridyl]boronic acid as a yellow solid (707 mg, 3.20 mmol, 59% yield). 1H NMR (11vu941h1, CDCl3): δ 8.29 (d, J=7.5 Hz, 1H) 7.34 (d, J=7.5 Hz, 1H) 5.92 (s, 2H) 4.10 (s, 3H);

Reference： [1]Current Patent Assignee: Syngenta (in: Sinochem Holdings); SINOCHEM HOLDINGS CORPORATION LTD - US2014/256546, 2014, A1 Location in patent: Page/Page column

12
2-fluoro-6-(trifluoromethyl)pyridine [ No CAS ]
[ 34486-18-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium hydroxide; water / 100 °C 2: silver carbonate / dichloromethane / 24 h / 20 °C / Darkness

Reference： [1]Current Patent Assignee: BEIGENE LTD.; BEIGNE - WO2018/103688, 2018, A1

13
[ 34486-18-5 ]
1-(5-chloro-4-fluoro-2-hydroxy-3-(2-methoxy-6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere 1.2: -78 - 20 °C 2.1: caesium carbonate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / 1,4-dioxane; water / 80 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: BEIGENE LTD.; BEIGNE - WO2018/103688, 2018, A1

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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere