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Chemical Structure| 346407-67-8 Chemical Structure| 346407-67-8

Structure of 346407-67-8

Chemical Structure| 346407-67-8

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Product Details of [ 346407-67-8 ]

CAS No. :346407-67-8
Formula : C9H13N3O2
M.W : 195.22
SMILES Code : O=C(C1=C(N)C(C2CCCC2)=NO1)N
MDL No. :MFCD17676927

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Application In Synthesis of [ 346407-67-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 346407-67-8 ]

[ 346407-67-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 346407-67-8 ]
  • [ 42926-52-3 ]
  • [ 346407-68-9 ]
YieldReaction ConditionsOperation in experiment
With pyridine;dmap; In methanol; dichloromethane; Example VII 3-Cyclopentyl-4-[(2-ethoxybenzoyl)amino]-isoxazole-5-carboxamide 390.5 mg (2.0 mmol) of 4-amino-3-cyclopentyl-isoxazole-5-carboxamide (example VI) are introduced, together with a catalytic quantity of 4-N,N-dimethylaminopyridine (DMAP), into 2.0 ml of pyridine. 553.9 mg (3.0 mmol) of <strong>[42926-52-3]2-ethoxybenzoyl chloride</strong> are added and the mixture is subsequently stirred at 60 C. for 5 h before a further 277 mg of <strong>[42926-52-3]2-ethoxybenzoyl chloride</strong> are added. After an additional 5 h at 60 C., the reaction mixture is taken up in dichloromethane and this solution is washed twice with saturated sodium hydrogencarbonate solution. The organic phase is dried over magnesium sulfate and concentrated on a rotary evaporator, and the residue is dried under high vacuum. Purification takes place by means of flash chromatography using dichloromethane/methanol 95:5. Yield: 168 mg (21% of theory) Rf value=0.368, dichloromethane/methanol 95:5 MS (DCI, NH3): m/z (%)=344 (M+H) (100) 1H-NMR (200 MHz, CDCl3): delta=1.61 (t, 3H); 1.62-1.89 (m, 6H); 2.03-2.17 (m, 2H); 3.54 (qui, 1H); 4.35 (q, 2H); 5.74 (bs, 1H); 6.48 (bs, 1H); 7.02-7.15 (m, 2H); 7.52 (dt, 1H); 8.27 (dd, 1H); 10.30 (bs, 1H).
 

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