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Chemical Structure| 346720-06-7 Chemical Structure| 346720-06-7

Structure of 346720-06-7

Chemical Structure| 346720-06-7

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Product Details of [ 346720-06-7 ]

CAS No. :346720-06-7
Formula : C14H12BrNO
M.W : 290.16
SMILES Code : O=C(NC1=CC=CC=C1Br)C2=CC=C(C)C=C2

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Application In Synthesis of [ 346720-06-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 346720-06-7 ]

[ 346720-06-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 346720-06-7 ]
  • [ 16112-21-3 ]
YieldReaction ConditionsOperation in experiment
85% General procedure: To an oven-dried Schlenk tube were added Na2S•9H2O (or K2S, 3.0mmol), o-haloanilide (1.0 mmol), and MCM-41-NHC-CuI (228 mg, 0.1 mmol). The tube was sealed and then evacuated and backfilled withargon, and DMF (2 mL) was injected with a syringe. The mixture washeated to 80 C with stirring for 12 h (140 C and 24 h for o-bromoanilide).Upon cooling to ambient temperature, the mixture was centrifugatedto separate the copper catalyst. The catalyst recovered waswashed with deionized water (3 × 2 mL) and acetone (3 × 2 mL) anddried in vacuo at 80 C for 1 h, and used in the next run. Then conc. HCl(0.8 mL) was added into the resultant solution. After stirring for 10 h atambient temperature, 10 mL saturated aq. NaHCO3 was added into thesolution and the resulting mixture was then extracted with EtOAc forthree times. After being washed with water and brine, the organic layerwas dried over anhydrous MgSO4 and concentrated under the reducedpressure. The residue was then purified via column chromatography onsilica gel (hexane/ethyl acetate) to furnish the expected product 2.
 

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