Home Cart Sign in  
Chemical Structure| 347161-74-4 Chemical Structure| 347161-74-4

Structure of 347161-74-4

Chemical Structure| 347161-74-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 347161-74-4 ]

CAS No. :347161-74-4
Formula : C17H15FN2O3
M.W : 314.31
SMILES Code : NC1=CC=C(OC2=CC=NC3=CC(OC)=C(OC)C=C23)C(F)=C1

Safety of [ 347161-74-4 ]

Application In Synthesis of [ 347161-74-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 347161-74-4 ]

[ 347161-74-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 23945-44-0 ]
  • [ 76-05-1 ]
  • [ 347161-74-4 ]
  • 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid [4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]amide trifluoroacetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
27% A solution of 2,4-dioxo-l,2,3,4-tetrahydro-pyrimidine-5- carboxylic acid (0.156 g, 1.00 mmol) in thionyl chloride (2 mL, 30 mmol) was stirred at 100 °C 3h. After the solvent was removed under vacuum, [ 4-(6,7-dimethoxy-quinolin-4- yloxy)-3-fluoro-phenylamine (0.314 g, 1.00 mmol) and pyridine (2 mL, 20 mmol) were added and stirred at room temperature 18 hr. The solvent was removed under vacuum and the residue was purified on HPLC. 0.15 g of the trifluoracetic acid salt was isolated in 27percent yield, mp 251-255 °C; LCMS m/z = 453 (M + 1); 1H NMR (DMSO) ?: 11.99 (bs, 1H), 11.93 (s, 1H),11.18 (s, 1H), 8.74 (d, 1H, J = 4.5 Hz), 8.31 (d, 1H, J = 7.5 Hz), 8.06 (d, 1H, J = 12 Hz), 7.70 (s, 1H), 7.55 (m, 2H), 7.51 (s, 1H), 6.85 (m, 1H), 4.02 (s, 3H), 4.01 (s, 3H).
  • 2
  • [ 22902-86-9 ]
  • [ 347161-74-4 ]
  • 2-(4-chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)acetamide [ No CAS ]
 

Historical Records