[ CAS No. 3482-14-2 ] {[proInfo.proName]}

Name: 3482-14-2|Isoquinolin-8-ol|98%
Brand: Ambeed
SKU: A126341
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Quality Control of [ 3482-14-2 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 3482-14-2 ]

SDS Specification

Alternatived Products of [ 3482-14-2 ]

Product Details of [ 3482-14-2 ]

CAS No. :	3482-14-2	MDL No. :	MFCD00661583
Formula :	C₉H₇NO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	ZIXWTPREILQLAC-UHFFFAOYSA-N
M.W :	145.16	Pubchem ID :	135441711
Synonyms :

Calculated chemistry of [ 3482-14-2 ]

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	10
Fraction Csp3 :	0.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	2.0
Num. H-bond donors :	1.0
Molar Refractivity :	43.77
TPSA :	33.12 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.94 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.37
Log Po/w (XLOGP3) :	1.75
Log Po/w (WLOGP) :	1.94
Log Po/w (MLOGP) :	0.92
Log Po/w (SILICOS-IT) :	2.01
Consensus Log Po/w :	1.6

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.52
Solubility :	0.443 mg/ml ; 0.00305 mol/l
Class :	Soluble
Log S (Ali) :	-2.06
Solubility :	1.26 mg/ml ; 0.00866 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.1
Solubility :	0.115 mg/ml ; 0.000791 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.12

Safety of [ 3482-14-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 3482-14-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 3482-14-2 ]
Downstream synthetic route of [ 3482-14-2 ]

[ 3482-14-2 ] Synthesis Path-Upstream 1~7

1
[ 119-65-3 ]
[ 3482-14-2 ]
[ 2439-04-5 ]

Reference： [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 9, p. 1065 - 1072

2
[ 3482-14-2 ]
[ 23687-27-6 ]

Reference： [1] Journal of the American Chemical Society, 1947, vol. 69, p. 1944

3
[ 1723-70-2 ]
[ 3482-14-2 ]

Yield	Reaction Conditions	Operation in experiment
98%	Stage #1: With boron tribromide In dichloromethane at 0 - 20℃; for 2.5 h; Heating / reflux Stage #2: at -78 - 20℃; for 0.5 h; Heating / reflux	To a stirred solution of 8-methoxyisoquinoline (7. 0g, 44mmol) in anhydrous CH2C12 (60 mL) cooled in an ice bath, was added over 0. 5H, boron tribromide, 1M in CH2C12 (Aldrich 21,122-2) (219 mL, 219 mmol). The reaction mixture was warmed to room temperature, heated at reflux for 2H, cooled TO-78°C, and decomposed by the addition OF CH30H (150 ML). The reaction mixture was warmed to room temperature, heated at reflux for 0. 5h and the solvent removed in vacuo. The residue was azeotrope with CH30H (3 x 100 ML) and suspended in H20 (150 mL). To this suspension was added CH2C12 (300 mL) and with vigorous stirring NEUTRALISED to c. a. 7.0 with ammonia (0. 88). The CH2C12 layer was separated and the aqueous layer extracted with CH2C12 (2 x 200 ML). The combined layers were dried (NA2S04) and the solvent removed in vacuo. The residue was purified by flash column chromatography to give the title compounds a pale yellow solid. (6.87g, 98percent). 1H NMR (400MHZ, DMSO-d6) 6 7.10 (1H), 7.45 (1H), 7. 65. (1H,), 7.75 (1H), 8.50 (1H), 9.50 (1H), 10.90 (1H).

Reference： [1] Patent: WO2005/5392, 2005, A1, . Location in patent: Page 52
[2] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 11, p. 2647 - 2666

4
[ 34784-07-1 ]
[ 3482-14-2 ]

Yield	Reaction Conditions	Operation in experiment
72%	With copper acetylacetonate; lithium hydroxide monohydrate; 1,3-bis(4-hydroxy-2,6-dimethylphenyl)urea In water; dimethyl sulfoxide at 130℃; for 24 h; Inert atmosphere	n 49. lmL dimethyl sulfoxide and 12.3 mL Water was added 10 g of a mixture of 61.35 mmol 8-chloroisoquinoline, 0.8], 3.07 mmol of copper acetylacetonate, 2.71 g, 64.42 mmol-hydrated hydroxide and 0.92 g, 3.07 mmol L-1,3-bis (4-hydroxy-2,6-dimethylphenyl) urea. The reaction solution was stirred at 130 ° C for 24 hours under nitrogen. After the reaction solution to be stirred was cooled, The solution was acidified with 2 mol / L HC1 to ρH- = 5, The mixture was extracted with ethyl acetate, The extracted organic phase was washed with saturated brine, Dried over anhydrous sodium sulfate and dried, The crude product was separated by column chromatography to give 8-hydroxyisoquinoline 6.41 g, the total yield was 72percent.

Reference： [1] Patent: CN106966977, 2017, A, . Location in patent: Paragraph 0016; 0018-0019

5
[ 135-02-4 ]
[ 3482-14-2 ]

Reference： [1] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 11, p. 2647 - 2666

6
[ 119-65-3 ]
[ 3482-14-2 ]
[ 2439-04-5 ]

Reference： [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 9, p. 1065 - 1072

7
[ 3482-14-2 ]
[ 32999-37-4 ]

Yield	Reaction Conditions	Operation in experiment
71%	at 20℃; for 1 h; Cooling	(0456) In an ice-water bath, isoquinolin-8-ol (2.9 g, 20 mmol) was dissolved in acetic acid (15 mL), and sodium borohydride (3.78 g, 100 mmol) was added slowly. After the addition, the mixture was warmed to room temperature and reacted for 1 h. After the reaction, the reaction solution was poured into ice (50 g), and extracted with ethyl acetate (100 mL×2). The organic phase was dried with anhydrous sodium sulfate, concentrated, and purified by silica gel column chromatography (petroleum ether:ethyl acetate=5:1) to get the title compound (2.12 g, yield: 71percent).

Reference： [1] Patent: US2017/112833, 2017, A1, . Location in patent: Paragraph 0455-0456

[ 3482-14-2 ] Synthesis Path-Downstream 1~58

1
[ 3482-14-2 ]
[ 104-78-9 ]
N,N-diethyl-N'-[8]isoquinolyl-propanediyldiamine [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1947,vol. 69,p. 1944

2
[ 3482-14-2 ]
[ 23687-27-6 ]

Reference： [1]Journal of the American Chemical Society,1947,vol. 69,p. 1944

3
[ 119-65-3 ]
[ 3482-14-2 ]
cis-7,8-Dihydroisoquinolin-7,8-diol [ No CAS ]
[ 2439-04-5 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1993,p. 1065 - 1072

4
[ 3482-14-2 ]
[ 206884-18-6 ]
8-(3-acetamido-2,6-dichlorobenzyloxy)isoquinoline [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,1999,vol. 7,p. 2647 - 2666

5
[ 1723-70-2 ]
[ 3482-14-2 ]

Yield	Reaction Conditions	Operation in experiment
98%		To a stirred solution of 8-methoxyisoquinoline (7. 0g, 44mmol) in anhydrous CH2C12 (60 mL) cooled in an ice bath, was added over 0. 5H, boron tribromide, 1M in CH2C12 (Aldrich 21,122-2) (219 mL, 219 mmol). The reaction mixture was warmed to room temperature, heated at reflux for 2H, cooled TO-78C, and decomposed by the addition OF CH30H (150 ML). The reaction mixture was warmed to room temperature, heated at reflux for 0. 5h and the solvent removed in vacuo. The residue was azeotrope with CH30H (3 x 100 ML) and suspended in H20 (150 mL). To this suspension was added CH2C12 (300 mL) and with vigorous stirring NEUTRALISED to c. a. 7.0 with ammonia (0. 88). The CH2C12 layer was separated and the aqueous layer extracted with CH2C12 (2 x 200 ML). The combined layers were dried (NA2S04) and the solvent removed in vacuo. The residue was purified by flash column chromatography to give the title compounds a pale yellow solid. (6.87g, 98%). 1H NMR (400MHZ, DMSO-d6) 6 7.10 (1H), 7.45 (1H), 7. 65. (1H,), 7.75 (1H), 8.50 (1H), 9.50 (1H), 10.90 (1H).

Reference： [1]Patent: WO2005/5392,2005,A1 .Location in patent: Page 52
[2]Bioorganic and Medicinal Chemistry,1999,vol. 7,p. 2647 - 2666

8
isoquinoline sulfate [ No CAS ]
[ 3482-14-2 ]

Reference： [1]Journal of the American Chemical Society,1947,vol. 69,p. 1944

9
[ 659729-09-6 ]
[ 3482-14-2 ]
8-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)isoquinoline [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 3515 - 3527

10
[ 3482-14-2 ]
[ 827309-88-6 ]

Yield	Reaction Conditions	Operation in experiment
92%	With hydrogen; acetic acid;platinum(IV) oxide; In ethanol; under 3000.3 Torr; for 18h;	To a stirred solution of <strong>[3482-14-2]Isoquinolin-8-ol</strong> (2. 0G, 13. 8MMOL) in ethanol (120 mL) was added acetic acid (2 ML) and platinum (IV) oxide (Aldrich 45,992-5) (0.2g). The reaction mixture was HYDROGENATED at ca. 4bar for 18H. THE CATALYST was filtered off and the solvent removed in vacuo to give the title compound as a tan solid (5.2g, 92%): HPLC retention time 2. 0MIN. Mass Spectrum (ES+) m/z 150 (M+H).

Reference： [1]Patent: WO2005/5392,2005,A1 .Location in patent: Page 52-53

11
[ 3482-14-2 ]
[ 862270-56-2 ]
8-(6-(4-(1-(4-fluorophenyl)ethyl)piperazin-1-yl)pyrimidin-4-yloxy)isoquinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With caesium carbonate; In dimethyl sulfoxide; at 115℃; for 0.5h;	A mixture of 4-fluoro-6-(4-(1-(4-fluorophenyl)ethyl)piperazin-1-yl)pyrimidine, Example 33(a), (0.05 g, 0.17 mmol), <strong>[3482-14-2]isoquinolin-8-ol</strong> (0.037 g, 0.25 mmol, Monomer Chem, Inc.) cesium carbonate (0.081 g, 0.25 mmol), and DMSO (1 mL) was heated in a microwave synthesizer at 115 C. for 0.5 h. The reaction mixture was allowed to cool to room temperature, diluted with H2O (30 mL) and extracted with DCM (2×50 mL). The combined organic extracts were washed with H2O (2×30 mL), dried over Na2SO4, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography (gradient: 0-8% MeOH/DCM) to give the title compound as a white solid. Mp: 114 C. MS (ESI, pos. ion) m/z: 430 (M+1).

Reference： [1]Patent: US2005/176726,2005,A1 .Location in patent: Page/Page column 34

12
[ 3482-14-2 ]
3-Acetoxymethyl-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-cephem-4-carboxylic acid [ No CAS ]
[ 16029-98-4 ]
[ 24589-78-4 ]
[ 55982-15-5 ]
syn-7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(8-hydroxyisoquinolinium-2-ylmethyl)-3-cephem-4-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In tetrahydrofuran; dichloromethane; acetonitrile;	EXAMPLE 6 syn-7-[2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(8-hydroxyisoquinolinium-2-ylmethyl)-3-cephem-4-carboxylate. To a suspension of 910 mg (2 mmole) of syn-7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid in 5 ml of methylene chloride were added 1.24 ml (7 mmole) of N-methyl-N-trimethylsilyltrifluoroacetamide and the mixture was warmed to 40 C. After a complete solution was obtained it was cooled to room temperature and 0.77 ml (5.4 mmole) of trimethylsilyliodide was added and the reaction mixture stirred under nitrogen at room temperature for 1.5 hours. The reaction mixture was evaporated and the silylated 3-iodomethyl derivative obtained as an oil was dissolved in 10 ml of acetonitrile. The solution was treated with 0.16 ml of tetrahydrofuran to destroy an TMSi complex or excess TMSi present in the solution. To the above solution of the silylated 3-iodomethyl derivative was added under nitrogen a solution of the trimethylsilyl derivative of <strong>[3482-14-2]8-hydroxyisoquinoline</strong> in acetonitrile (prepared by treating a suspension of 348 mg (2.4 mmole) of <strong>[3482-14-2]8-hydroxyisoquinoline</strong> in 10 ml of acetonitrile with 0.43 ml of mono-trimethylsilyltrifluoroacetamide). The mixture was stirred at room temperature for 2.5 hours and was then diluted with a small amount of diethyl ether and then with water. The product precipitated as a thick, tan precipitate. After stirring the mixture for 10 minutes, the product was separated by filtration and was washed with diethyl ether. The product was dried under vacuum at 40 C. for 1.5 hours to yield 1.27 g of impure product.

Reference： [1]Patent: US4396619,1983,A

13
[ 3482-14-2 ]
[ 845654-95-7 ]
[ 1190841-31-6 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 5250 - 5255

14
[ 135-02-4 ]
[ 3482-14-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry,1999,vol. 7,p. 2647 - 2666

15
[ 3482-14-2 ]
[ 106-94-5 ]
[ 820238-28-6 ]

Yield	Reaction Conditions	Operation in experiment
63%		Synthesis of 8-propoxy-isoquinoline (2)To a solution of <strong>[3482-14-2]8-hydroxy-isoquinoline</strong> (1) (1.7 g, 11.7 mmol) in DMF (20 ml) at 0 C was added NaH (940 mg, 23.4 mmol, 2.0 eq.). The mixture was stirred for 30 min.Bromopropane (1.6 ml, 17.6 mmol, 1.5 eq.) was then added. The reaction was allowed to warm to RT and was stirred for 1 h. The reaction was diluted with EtOAc and washed with water. The organic layer was dried over MgS04 and concentrated. The residue was purified by flash chromatography (cyclohexane/EtOAc 10/0 to 8/2) to afford 1.4 g (63 %) of 8-propoxy-isoquinoline (2) as red oil.*H NMR (300 MHz,DMSO-d6) delta : 9.66 (s, 1H), 8.52 (d, ] = 5.8 Hz, 1H), 8.17 (d, 3 = 7.1 Hz, 1H), 7.8 (t, 3 = 8.1 Hz, 1H), 7.65 (d, 3 = 8.2 Hz, 1H), 7.28 (d, 3 - 7.8 Hz, 1H), 4.02 (s, 3H).
63%		Synthesis of 8-propoxy-isoquinoline (2) To a solution of <strong>[3482-14-2]8-hydroxy-isoquinoline</strong> (1) (1.7 g, 11.7 mmol) in DMF (20 ml) at 0 C was added NaH (940 mg, 23.4 mmol, 2.0 eq.). The mixture was stirred for 30 min. Bromopropane (1.6 ml, 17.6 mmol, 1.5 eq.) was then added. The reaction was allowed to warm to RT and was stirred for 1 h. The reaction was diluted with EtOAc and washed with water. The organic layer was dried over MgSO4 and concentrated. The residue was purified by flash chromatography (cyclohexane/EtOAc 10/0 to 8/2) to afford 1.4 g (63 %) of 8-propoxy-isoquinoline (2) as red oil. 1H NMR (300 MHz,DMSO-d6) delta : 9.66 (s, 1H), 8.52 (d, J = 5.8 Hz, 1H), 8.17 (d, J = 7.1 Hz, 1H), 7.8 (t, J = 8.1 Hz, 1H), 7.65 (d, J = 8.2 Hz, 1H), 7.28 (d, J = 7.8 Hz, 1H), 4.02 (s, 3H).

Reference： [1]Patent: WO2011/57784,2011,A1 .Location in patent: Page/Page column 11
[2]Patent: EP2332917,2011,A1 .Location in patent: Page/Page column 7

16
[ 3482-14-2 ]
8-propoxy-isoquinoline 2-oxide hydrochloride [ No CAS ]

Reference： [1]Patent: WO2011/57784,2011,A1

17
[ 3482-14-2 ]
[ 1231948-58-5 ]

Reference： [1]Patent: WO2011/57784,2011,A1
[2]Patent: EP2332917,2011,A1

18
[ 3482-14-2 ]
[ 1231948-59-6 ]
[ 1231948-60-9 ]

Reference： [1]Patent: WO2011/57784,2011,A1

19
[ 3482-14-2 ]
[ 1231948-59-6 ]

Reference： [1]Patent: EP2332917,2011,A1

20
[ 3482-14-2 ]
[ 1231948-60-9 ]

Reference： [1]Patent: EP2332917,2011,A1

21
[ 3482-14-2 ]
[ 1231948-57-4 ]

Reference： [1]Patent: EP2332917,2011,A1

22
[ 3482-14-2 ]
[ 1307298-14-1 ]

Reference： [1]Patent: EP2332917,2011,A1

23
[ 3482-14-2 ]
[ 1430746-24-9 ]
[ 1430745-59-7 ]

Yield	Reaction Conditions	Operation in experiment
16.2%	With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; at 20℃; for 19h;Inert atmosphere;	To a solution of (lR,3s,5S)-tert-butyl 3-((ls,4S)-4-hydroxycyclohexyloxy)-8- azabicyclo[3.2.1]octane-8-carboxylate (100 mg, 0.307 mmol), <strong>[3482-14-2]isoquinolin-8-ol</strong> (53.52 mg, 0.369 mmol), and triphenylphosphine (96.71 mg, 0.369 mmol) in THF (2 mL) at room temperature under nitrogen was added triethylamine (51.39 mu?, 0.369 mmol), followed by dropwise addition of diisopropyl diazene-l,2-dicarboxylate (72.81 mu?, 0.369 mmol). After 19 h stirring at room temperature, the mixture was concentrated in vacuo and purified by preparative HPLC. Pure fractions were combined, neutralized with saturated sodium bicarbonate (aq), and evaporated MeCN. The aqueous residue was extracted with DCM (twice) and the combined organics were dried over anhydrous sodium sulfate. After removal of drying agent by filtration, the filtrate was concentrated in vacuo and dried under reduced pressure to give the title compound (22.5 mg, 49.71 muiotaetaomicron?, 16.2%) as a grapefruit color solid. Exact mass calculated for C27H36N2O4: 452.3, found: LCMS m/z = 453.4 [M+H]+; lU NMR (400 MHz, CDC13) delta ppm 1.47 (s, 9H), 1.49-1.82 (m, 8H), 1.87-1.99 (m, 4H), 2.00-2.11 (m, 2H), 2.14-2.25 (m, 2H), 3.51-3.63 (m, 1H), 3.78-3.92 (m, 1H), 4.20 (br s, 1H), 4.30 (br s, 1H), 4.50-4.61 (m, 1H), 6.91 (d, = 7.8 Hz, 1H), 7.34 (d, = 8.3 Hz, 1H), 7.52-7.61 (m, 2H), 8.51 (d, = 5.8 Hz, 1H), 9.62 (s, 1H).

Reference： [1]Patent: WO2013/55910,2013,A1 .Location in patent: Page/Page column 123

24
[ 3482-14-2 ]
C₉H₅Br₂NO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
96%	With bromine; sodium hydrogencarbonate; In methanol; at 20℃; for 0.0833333h;	Above in Scheme 5 and as shown, 100 ml 2-neck (neck) flask to <strong>[3482-14-2]8-hydroxy-isoquinoline</strong> (hydroxyisoquinoline) (2.0 g, 13.8 mmol), sodium hydrogen carbonate (sodium bicarbonate) (2.3 g, 27.6 mmol) to into methanol (methanol) 25 ml Enoch Indah. By the addition of bromine (bromine) diluted in 2.1 ml of methanol (MeOH) 25 ml mixture was stirred at room temperature for 5 minutes. After sodium sulfite (Sodium sulfite) inserting a 1.5 g given by sufficiently stirring, filter the mixture and rinse with 50 ml water to give the subject compound in 4.0 g (96%)

Reference： [1]Patent: KR2016/83249,2016,A .Location in patent: Paragraph 0057; 0058; 0059

25
[ 3482-14-2 ]
C₉H₄BrNO₂ [ No CAS ]

Reference： [1]Patent: KR2016/83249,2016,A

26
[ 3482-14-2 ]
C₁₇H₇F₆NO₂ [ No CAS ]

Reference： [1]Patent: KR2016/83249,2016,A

27
[ 3482-14-2 ]
C₂₃H₇F₆N₅ [ No CAS ]

Reference： [1]Patent: KR2016/83249,2016,A

28
[ 3482-14-2 ]
C₂₀H₇F₆N₃O [ No CAS ]

Reference： [1]Patent: KR2016/83249,2016,A

29
[ 3482-14-2 ]
C₂₉H₇F₁₀N₅ [ No CAS ]

Reference： [1]Patent: KR2016/83249,2016,A

30
[ 3482-14-2 ]
C₃₅H₇F₁₄N₅ [ No CAS ]

Reference： [1]Patent: KR2016/83249,2016,A

31
[ 3482-14-2 ]
C₂₈H₇F₁₁N₄ [ No CAS ]

Reference： [1]Patent: KR2016/83249,2016,A

32
[ 3482-14-2 ]
C₃₃H₇F₁₆N₃ [ No CAS ]

Reference： [1]Patent: KR2016/83249,2016,A

33
[ 3482-14-2 ]
[ 32999-37-4 ]

Yield	Reaction Conditions	Operation in experiment
71%	With sodium tetrahydroborate; acetic acid; at 20℃; for 1h;Cooling;	(0456) In an ice-water bath, isoquinolin-8-ol (2.9 g, 20 mmol) was dissolved in acetic acid (15 mL), and sodium borohydride (3.78 g, 100 mmol) was added slowly. After the addition, the mixture was warmed to room temperature and reacted for 1 h. After the reaction, the reaction solution was poured into ice (50 g), and extracted with ethyl acetate (100 mL×2). The organic phase was dried with anhydrous sodium sulfate, concentrated, and purified by silica gel column chromatography (petroleum ether:ethyl acetate=5:1) to get the title compound (2.12 g, yield: 71%).

Reference： [1]Patent: US2017/112833,2017,A1 .Location in patent: Paragraph 0455-0456

34
[ 3482-14-2 ]
2-acetyl-1,2,3,4-tetrahydroisoquinoline-8-yl acetate [ No CAS ]