Alternatived Products of [ 349662-62-0 ]
Product Details of [ 349662-62-0 ]
CAS No. : | 349662-62-0 |
MDL No. : | MFCD20696628 |
Formula : |
C7H9NO3S
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
187.22
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 349662-62-0 ]
Application In Synthesis of [ 349662-62-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 349662-62-0 ]
- 1
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[ 40235-68-5 ]
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[ 105-34-0 ]
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[ 349662-62-0 ]
Yield | Reaction Conditions | Operation in experiment |
51% |
With sodium sulfide nonahydrate; triethylamine In methanol |
173.A methyl 2-amino-4-(hydroxymethyl)thiophene-3-carboxylate
Example 173A methyl 2-amino-4-(hydroxymethyl)thiophene-3-carboxylate A solution of methyl cyanoacetate (1.18 mL, 13.28 mmol) and sodium sulfide nonahydrate (3.20 g, 13.28 mmol) in methanol (25 mL) at 0° C. was treated with 1-acetoxy-3-chloroacetone (2.0 g, 13.28 mmol). The cold bath was removed and triethylamine (1.86 mL, 13.28 mmol) was added dropwise. The solution was stirred at room temperature for 20 hours then diluted with water and extracted into ethyl acetate. The organic layer was dried over sodium sulfate, filtered, and the solvent removed under vacuum to provide the titled compound (1.25 g, 51%). MS (DCI/NH3) M/z 188 (M+H)+; 1H NMR (300 MHz, DMSO-d6) δ 3.68 (s, 3H) 4.45 (dd, J=5.52, 1.47 Hz, 2H) 4.88 (t, J=5.70 Hz, 1H) 6.12 (s, 1H) 7.28 (s, 2H |
51% |
With sodium sulfide; triethylamine In methanol at 0 - 20℃; for 20h; |
173A EXAMPLE 173 7-benzyl-5-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-3-(hydroxymethyl)-7,7a-dihydrothieno[2,3-b]pyridin-6(3aH)-one EXAMPLE 173A methyl 2-amino-4-(hydroxymethyl)thiophene-3-carboxylate
A solution of methyl cyanoacetate (1.18 ML, 13.28 mmol) and sodium sulfide nonahydrate (3.20 g, 13.28 mmol) in methanol (25 ML) at 0° C. was treated with 1-acetoxy-3-chloroacetone (2.0 g, 13.28 mmol).The cold bath was removed and triethylamine (1.86 ML, 13.28 mmol) was added dropwise.The solution was stirred at room temperature for 20 hours then diluted with water and extracted into ethyl acetate.The organic layer was dried over sodium sulfate, filtered, and the solvent removed under vacuum to provide the titled compound (1.25 g, 51%). MS (DCI/NH3) m/z 188 (M+H)+; 1H NMR (300 MHz, DMSO-d6) δ 3.68 (s, 3 H) 4.45 (dd, J=5.52, 1.47 Hz, 2 H) 4.88 (t, J=5.70 Hz, 1 H) 6.12 (s, 1 H) 7.28 (s, 2 H) |