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Chemical Structure| 350584-53-1 Chemical Structure| 350584-53-1

Structure of 350584-53-1

Chemical Structure| 350584-53-1

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Product Details of [ 350584-53-1 ]

CAS No. :350584-53-1
Formula : C12H9F3O4S
M.W : 306.26
SMILES Code : O=S(C(F)(F)F)(OC1=C2C=CC(OC)=CC2=CC=C1)=O

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Application In Synthesis of [ 350584-53-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 350584-53-1 ]

[ 350584-53-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 201230-82-2 ]
  • [ 350584-53-1 ]
  • [ 36112-61-5 ]
YieldReaction ConditionsOperation in experiment
65% To a solution of 0.96 g (3.18 mmol) of 6-methoxy-1-naphthyl trifluoromethanesulfonate in 30 mL of DMF was added 0.034 g (0.15 mmol) of Pd(OAc)2, 0.040 g (0.010 mmol) of 1,3-bis(diphenylphosphino)propane and 1.20 g of triethylamine. The mixture was flushed with carbon monoxide for 25 min, 3.1 mL of 96% formic acid was added dropwise and the reaction was stirred at ambient temperature for 6 h under an atmosphere of CO, diluted with water and extracted with ethyl acetate. The organic extracts were washed with five portions of brine, followed by two portions of aqueous NaHCO3. The bicarbonate extracts were combined, cautiously neutralized with 10% aqueous HCl, and extracted with ether. The ethereal extracts were washed with water, dried (MgSO4) and the solvent was removed in vacuo to give 0.42 g (65%) of acid 35 as a yellow powder. Recrystallization from ethyl acetate:petroleum ether gave pale yellow needles: m.p. 185-186 (lit mp 180-180.5 C., ref. 36); 1H NMR (300 MHz, CDCl3) delta 3.89 (s, 3H), 7.29 (dd, J=6.9, 2.4 Hz, 1H), 7.41 (d, J=2.4 Hz, 1H), 7.53 (t, J=7.8 Hz, 1H), 7.98 (d, J=6.1 Hz, 1H), 8.05 (d, J=8.1 Hz, 1H), 8.79 (d, J=9.1 Hz, 1H); 13C NMR (75.5 MHz, CDCl3) delta 55.2, 106.7, 120.0, 125.4, 126.1, 127.1, 127.5, 127.6, 131.8, 135.2, 157.1, 168.8; MS (EI) m/z 202 (100), 159 (35), 109 (50).
 

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