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Chemical Structure| 35218-42-9 Chemical Structure| 35218-42-9

Structure of 35218-42-9

Chemical Structure| 35218-42-9

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Product Details of [ 35218-42-9 ]

CAS No. :35218-42-9
Formula : C10H8N2O2
M.W : 188.18
SMILES Code : O=C(C1=CC=CO1)NC2=CC=NC=C2

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Application In Synthesis of [ 35218-42-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35218-42-9 ]

[ 35218-42-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4876-10-2 ]
  • [ 35218-42-9 ]
  • [ 953065-10-6 ]
YieldReaction ConditionsOperation in experiment
95% With sodium hydride; In N,N-dimethyl-formamide; at 40℃; for 2h; Step 2: N-[(2-Oxo-1,2-dihydroquinolin-4-yl)methyl]-N-(pyridin-4-yl)-2-furamide Sodium hydride (40 mg, 1 mmol) and <strong>[4876-10-2]4-(bromomethyl)quinolin-2(1H)-one</strong> (700 mg, 2.94 mmol) were added to a solution of N-(pyridin-4-yl)furan-2-carboxamide (200 mg, 1.06 mmol) in DMF (25 ml). The reaction mixture was stirred for 2 h at 40° C. The solvent was removed and the residue was purified by silica gel flash column chromatography (10percent MeOH in dichloromethane) to afford 0.35 g (95percent) of N-((2-oxo-1,2-dihydroquinolin-4-yl)methyl)-N-(pyridin-4-yl)-2-furamide as a white solid. LCMS: 346.0 (M+H)+.
 

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