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Chemical Structure| 352328-41-7 Chemical Structure| 352328-41-7

Structure of 352328-41-7

Chemical Structure| 352328-41-7

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Product Details of [ 352328-41-7 ]

CAS No. :352328-41-7
Formula : C8H6ClN3S
M.W : 211.67
SMILES Code : CSC1=NC=C(C=CC(Cl)=N2)C2=N1
MDL No. :MFCD18072556

Safety of [ 352328-41-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 352328-41-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 352328-41-7 ]

[ 352328-41-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 211244-81-4 ]
  • [ 352328-41-7 ]
YieldReaction ConditionsOperation in experiment
61% With trichlorophosphate; at 80℃; for 16h;Inert atmosphere; 7-chloro-2-(methylthio)pyrido[2,3-d]pyrimidine A suspension of <strong>[211244-81-4]2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one</strong> (297 mg, 1.54 mmol) in POCI3 (6 mL) was stirred under argon at 80C for 16 hours. The solution was cooled, and the resulting precipitate was filtered and washed with EtOAc to afford the title compound (43 mg, 13%). The filtrate was diluted with EtOAc, washed with NaHC03 and dried with Na2S04. After removal of the solvent, a second crop was obtained (154 mg, 48%). [00317] H NMR (500 MHz, DMSO-d6): delta 9.52 (s, 1 H), 8.61 (d, J = 8.4 Hz, 1 H), 7.74 (d, J = 8.4 Hz, 1 H), 2.63 (s, 3H). LCMS (ESI) Rt =1 .98 minutes MS m/z 212 [M+H]+
In trichlorophosphate; EXAMPLE 6 7-Chloro-2-methylsulfanyl-pyrido[2,3-d]pyrimidine A suspension of 1.0 g (5.2 mmol) of <strong>[211244-81-4]2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one</strong> (Example 5) in 10 mL of phosphorus oxychloride is heated under reflux for 1 hour. The resulting solution is cooled and concentrated to give a solid, which is triturated with cold water and filtered to give 1.05 g of crude product. Recrystallization from acetonitrile lives 0.76 g (69%) of the product, mp 201-203 C. MS (APCI) M+1: Calcd 212.0: Found 212.0. Anal. Calcd for C8H6Cl1S1N3: C, 45.39: H, 2.86: N, 19.85. Found: C, 45.53: H, 2.90: N, 19.74.
 

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