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Chemical Structure| 35291-92-0 Chemical Structure| 35291-92-0

Structure of 35291-92-0

Chemical Structure| 35291-92-0

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Product Details of [ 35291-92-0 ]

CAS No. :35291-92-0
Formula : C12H15ClO2
M.W : 226.70
SMILES Code : O=C(Cl)C1=CC=C(C(C)(C)C)C(OC)=C1
MDL No. :MFCD17015689

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Application In Synthesis of [ 35291-92-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35291-92-0 ]

[ 35291-92-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 35291-92-0 ]
  • [ 129799-08-2 ]
  • [ 863329-79-7 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; at 20℃; for 18h; To a solution of Intermediate 2 (1.0 g, 4.1 mmol) in anhydrous dichloromethane (40 mL) was added triethylamine (0.82 mL, 5.9 mmol) and 3-methoxy-4-tert-butylbenzoyl chloride* (1.11 g, 4.9 mmol). The resultant mixture was stirred at ambient temperature for 18 hours and washed with water. The organic phase was separated and evaporated to a gum, then purified by chromatography over silica gel using cyclohexane-ethyl acetate (4: 1, 3: 1 and then 2: 1 v/v) as eluent. The fractions containing the desired product were combined and evaporated to give the title compound as an amorphous solid. MS calcd for (C23H34N206 + H) + : 435. Found: (M+H) + = 435. * Prepared from 3-methoxy-4-tert-butylbenzoic acid (J. Org. Chem. (1961) 26,1732) using thionyl chloride.
 

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