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Chemical Structure| 35368-75-3 Chemical Structure| 35368-75-3

Structure of 35368-75-3

Chemical Structure| 35368-75-3

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Product Details of [ 35368-75-3 ]

CAS No. :35368-75-3
Formula : C8H8BrNO2
M.W : 230.06
SMILES Code : O=C(N)COC1=CC=C(Br)C=C1
MDL No. :MFCD00466099

Safety of [ 35368-75-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 35368-75-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35368-75-3 ]

[ 35368-75-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1878-91-7 ]
  • [ 35368-75-3 ]
YieldReaction ConditionsOperation in experiment
70% With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20℃; for 2h; To a solution of <strong>[1878-91-7](4-bromophenoxy)acetic acid</strong> (500 mg, 2.00 mmol) in dichloromethane (10 mL) and DMF (0.2 mL) was added 2 M oxalyl chloride in methylene chloride (5 mL, 10 mmol). The reaction mixture was stirred at room temperature for 2 hours, and the solvent was removed under reduced pressure. Ammonium hydroxide (15 mL) was added dropwise via additional funnel. After addition, the mixture was extracted with EtOAc (3*20 mL). The combined organic layers were dried and concentrated in vacuo to give 2-(4-bromophenoxy)acetamide (350 mg, 70% yield) as a yellow solid. 1H NMR (400 MHz, CDCl3): delta 7.37-7.35 (m, 2H), 6.81-6.79 (m, 2H), 4.59 (s, 2H).
 

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