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Chemical Structure| 3556-52-3 Chemical Structure| 3556-52-3

Structure of 3556-52-3

Chemical Structure| 3556-52-3

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Product Details of [ 3556-52-3 ]

CAS No. :3556-52-3
Formula : C7H5FN2O3
M.W : 184.12
SMILES Code : O=C(N)C1=CC=C([N+]([O-])=O)C(F)=C1
MDL No. :MFCD16658739

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Application In Synthesis of [ 3556-52-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3556-52-3 ]

[ 3556-52-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 455-37-8 ]
  • [ 3556-52-3 ]
YieldReaction ConditionsOperation in experiment
44% With sulfuric acid; nitric acid; at 10℃; Amide 18 (20 g, 144 mmol) was dissolved in cone, nitric acid (40 mL) and added dropwise to a mixture of cone, sulphuric acid (70 mL) and cone, nitric acid (10 mL) while <n="39"/>keeping the temperature <10 0C. The mixture was partitioned between water (1 L) and ethylacetate (IL) and the organic phase separated, dried (MgSO4) and evaporated to an oil. This was suspended in ethylacetate (100 mL) and heated. Hexane (100 mL) was added and the mixture was cooled to -20C overnight. The resulting crystalline solid was collected by filtration and washed with hexane to give nitroamide 19 as white crystals (11.5 g, 44%): m.p. 129-130 C.
 

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