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CAS No. : | 35779-35-2 | MDL No. : | MFCD01464076 |
Formula : | C11H8N2O | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | AQLPDLOXKZRZEV-UHFFFAOYSA-N |
M.W : | 184.19 | Pubchem ID : | 298471 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
49% | Stage #1: With n-butyllithium In diethyl ether at -78℃; for 0.25 h; Stage #2: at -78℃; for 2 h; |
n-BuLi (71.3 ml, 1.6 M, 0.114 mol) was added dropwise to the solution of 3-bromo pyridine (15 g, 0.095 mol) in dry diethyl ether (200 ml) at -78° C. and stirred for 15 minutes. A solution of ethyl nicotinate (13 g, 0.095 mol) in dry diethyl ether (50 ml) was added dropwise to the reaction mixture at -78° C. and stirred for another 2 h at the same temperature. Then the reaction was quenched with satd. ammonium chloride and extracted with ethyl acetate. The organic layer was washed with satd. brine, dried over anh. sodium sulfate and concentrated. The crude product was purified on neutral alumina column using (methanol/dichloromethane) to give the sub-title compound (8.5 g, 49percent as brown liquid. |
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