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Chemical Structure| 362670-07-3 Chemical Structure| 362670-07-3

Structure of 362670-07-3

Chemical Structure| 362670-07-3

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Product Details of [ 362670-07-3 ]

CAS No. :362670-07-3
Formula : C11H15FN2O2
M.W : 226.25
SMILES Code : O=C(OC(C)(C)C)NC1=CC(F)=CC=C1N
MDL No. :MFCD07787180
InChI Key :FELBQUPQCJZQQX-UHFFFAOYSA-N
Pubchem ID :53420357

Safety of [ 362670-07-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H317
Precautionary Statements:P280

Application In Synthesis of [ 362670-07-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 362670-07-3 ]

[ 362670-07-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 362670-07-3 ]
  • [ 24242-20-4 ]
  • tert-butyl (2-(5-aminopicolinamido)-5-fluorophenyl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
72% With triethylamine; In N,N-dimethyl-formamide; at 20℃; for 12h;Inert atmosphere; A mixture of 5-aminopicolinic acid (159 mg, 1.1 mmol), tert-butyl (2-amino-5- fluorophenyl)carbamate (69, 248 mg, 1.1 mmol), triethylamine (333 mg, 3.3 mmol) in dimethylformamide (2.0 mL) was flushed with argon, and stirred at r.t. for 12 hours. The reaction mixture extracted with ice water (20.0 mL) and ethyl acetate (5.0 mL x 3). The combined organic extracts were washed with 2M HCl (aq) (5.0 mL), NaHCO3 (Sat) (25.0 mL). The combined organic layers were dried over Na2SO4 The crude product was purified with flash column chromatography on silica gel, and using 20percent Ethyl acetate/Hexanes to afford the 72 [tert-butyl(2-(5-aminopicolinamido)-5-fluorophenyl)carbamate]. The yield is 72percent, and as off white solid.: NMR (DMSO, 500 MHz): delta 1.49 (s, 9H), 6.11 (s, 2H), 7.02-7.07 (m, 2H), 7.14- 7.16 (m, 1H), 7.81 (d, 1H, J= 8.5 Hz), 7.87-7.90 (m, lH), 7.93 (s, 1H), 9.09 (s, 1H), 10.10 (s, 1H).
 

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