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CAS No. : | 364794-57-0 | MDL No. : | MFCD09910224 |
Formula : | C11H16BrN3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 270.17 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With potassium carbonate In dimethyl sulfoxide at 120℃; for 2h; Microwave irradiation; | 1-(5-Bromopyridin-2-yI)-4-ethylpiperazine (B52 .1) A mixture of 5-bromo-2- fluoropyridine (500 mg, 2.84 mmol), 1-ethylpiperazine (487 mg, 4.26 mmol), and K2C03(668 mg, 4.83 mmol) in DMSO (7 mL) was heated in microwave at 120 °C for2 h. Satd. aq. NaHCO3 solution was added, and the mixture was extracted with EtOAc, dried, concentrateed, and purified by flash chromatography to afford the title compound (756 mg, 98% yield) as a pale yellow syrup. 1H NMR (CDCI3, 400M Hz) O (ppm): 8.21 (5, 1H), 7.54 (dd, 1H), 7.28 (5, 1H), 6.57 (d, 1H), 3.56 (5, 4H), 2.57 (5, 4H), 2.49 (dd, 2H), 1.16 (t,3H); LCMS: [MH] 271.9. |