Home Cart 0 Sign in  
X

[ CAS No. 36692-49-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 36692-49-6
Chemical Structure| 36692-49-6
Chemical Structure| 36692-49-6
Structure of 36692-49-6 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 36692-49-6 ]

Related Doc. of [ 36692-49-6 ]

Alternatived Products of [ 36692-49-6 ]

Product Details of [ 36692-49-6 ]

CAS No. :36692-49-6 MDL No. :MFCD00017098
Formula : C8H10N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :IOPLHGOSNCJOOO-UHFFFAOYSA-N
M.W : 166.18 Pubchem ID :135524
Synonyms :

Calculated chemistry of [ 36692-49-6 ]

Physicochemical Properties

Num. heavy atoms : 12
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.12
Num. rotatable bonds : 2
Num. H-bond acceptors : 2.0
Num. H-bond donors : 2.0
Molar Refractivity : 46.53
TPSA : 78.34 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.99 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.16
Log Po/w (XLOGP3) : 0.46
Log Po/w (WLOGP) : 0.65
Log Po/w (MLOGP) : 0.74
Log Po/w (SILICOS-IT) : 0.26
Consensus Log Po/w : 0.65

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.4
Solubility : 6.64 mg/ml ; 0.04 mol/l
Class : Very soluble
Log S (Ali) : -1.67
Solubility : 3.52 mg/ml ; 0.0212 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -1.75
Solubility : 2.97 mg/ml ; 0.0179 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.32

Safety of [ 36692-49-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 36692-49-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 36692-49-6 ]
  • Downstream synthetic route of [ 36692-49-6 ]

[ 36692-49-6 ] Synthesis Path-Upstream   1~18

  • 1
  • [ 506-68-3 ]
  • [ 36692-49-6 ]
  • [ 76391-97-4 ]
YieldReaction ConditionsOperation in experiment
97%
Stage #1: at 20℃;
Stage #2: With ammonia In water; ethyl acetate; acetonitrile
Stage #3: With hydrogenchloride In waterReflux
A solution of cyanogen bromide (5.0 mL, 5 M in acetonitrile, 25 mmol) was added to a mixture of methyl 3,4-diaminobenzoate (3.0 g, 18 mmol) in water (50 mL). The reaction was stirred at room temperature overnight. Aqueous ammonia (20 mL) and ethyl acetate (100 mL) were added to the reaction mixture and the layers were separated. The organics were dried over sodium sulfate, filtered, and concentrated. To the crude residue was added 2 N aqueous hydrochloric acid (18 mL, 36.0 mmol) and the mixture was heated at reflux overnight. The reaction was concentrated to give the title compound (2.90 g, 97percent). 1H NMR (400 MHz, DMSO-d6, δ): 8.75 (s, 2H), 7.84 (s, 1H), 7.77 (dd, J=1.2, 8.4 Hz, 1H), 7.38 (d, J=8.4 Hz, 1H).
97%
Stage #1: at 20℃;
Stage #2: With ammonia In water; ethyl acetate
Stage #3: Reflux
Intermediate 14 : 2-amino-1H-benzo[d]imidazole-5-carboxylic acid, shown below, was prepared as follows:A solution of cyanogen bromide (5.0 mL, 5 M in acetonitrile, 25 mmol) was added to a mixture of methyl 3,4-diaminobenzoate (3.0 g, 18 mmol) in water (50 mL). The reaction was stirred at room temperature overnight. Aqueous ammonia (20 mL) and ethyl acetate (100 mL) were added to the reaction mixture and the layers were separated. The organics were dried over sodium sulfate, filtered, and concentrated. To the crude residue was added 2 N aqueous hydrochloric acid (18 mL, 36.0 mmol) and the mixture was heated at reflux overnight. The reaction was concentrated to give the title compound (2.90 g, 97percent). 1H NMR (400 MHz, DMSO-d6, δ): 8.75 (s, 2H), 7.84 (s, 1H), 7.77 (dd, J=1.2 Hz, J=8.4 Hz, 1H), 7.38 (d, J=8.4 Hz, 1H).
Reference: [1] Patent: US2012/108619, 2012, A1, . Location in patent: Page/Page column 39
[2] Patent: US2012/270893, 2012, A1, . Location in patent: Page/Page column 27
  • 2
  • [ 36692-49-6 ]
  • [ 530-62-1 ]
  • [ 106429-57-6 ]
YieldReaction ConditionsOperation in experiment
94% at 0℃; for 16 h; To a solution of 3,4-diamino-benzoic acid methyl ester (5.00 g, 30.1 mmol) and THF (40 ml_), was added carbonyl diimidazole (7.32 g, 45.1 mmol) at 0 0C. The mixture stirred for 16 h, and allowed to warm to 23 0C. A solution of 1 M aq. HCI (50 ml_) was added at 0 0C, followed by water (70 ml_) and the mixture was stirred for 1 h. The resulting precipitate was filtered and dried under reduced pressure for 18 h to yield the titled compound, which was used in the next step without further purification (5.45 g, 94 percent). MS (ESI/CI): mass calcd. for C9H8N2O3, 192.1 ; m/z found, 193.1 [M+H]+. 1H NMR (400 MHz, CDCI3): 11.01 (s, 1 H), 10.84 (s, 1 H), 7.63 (dd, J = 8.2, 1.6 Hz, 1 H), 7.47 (s, 1 H), 7.02 (d, J = 8.2 Hz, 1 H), 3.82 (s, 3H).
Reference: [1] Patent: WO2009/134750, 2009, A1, . Location in patent: Page/Page column 139
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 12, p. 3719 - 3742
[3] Patent: US2010/249124, 2010, A1, . Location in patent: Page/Page column 62
[4] Cell Chemical Biology, 2018, vol. 25, # 6, p. 677 - 12,690
  • 3
  • [ 36692-49-6 ]
  • [ 144-62-7 ]
  • [ 26663-77-4 ]
Reference: [1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 8, p. 1337 - 1342
  • 4
  • [ 36692-49-6 ]
  • [ 68-12-2 ]
  • [ 26663-77-4 ]
Reference: [1] New Journal of Chemistry, 2016, vol. 40, # 10, p. 8282 - 8287
  • 5
  • [ 36692-49-6 ]
  • [ 71605-72-6 ]
Reference: [1] Medicinal Chemistry Research, 2015, vol. 24, # 8, p. 3143 - 3156
  • 6
  • [ 36692-49-6 ]
  • [ 89795-51-7 ]
Reference: [1] Medicinal Chemistry Research, 2015, vol. 24, # 8, p. 3143 - 3156
  • 7
  • [ 67-56-1 ]
  • [ 619-05-6 ]
  • [ 36692-49-6 ]
YieldReaction ConditionsOperation in experiment
95% for 4 h; Inert atmosphere To a solution of 3,4-diamino-benzoic acid (1.00 g, 6.58 mmol) in 15.0 ml of Methanol, thionyl chloride (0.72 ml, 9.80 mmol) was added dropwise for 10 min. After 4 h, evaporationg the solvent, the reaction mixture was partitioned between water and EtOAc. The organic layer was diluted with EtOAc and sequentially washed with aqueous sodium bicarbonate, brine and water, and dried over anhydrous magnesium sulfate. The solvent was filtered and evaporated. Under reduced pressure to afford a 3,4-Diamino-benzoic acid methyl ester, as a brown solid (993 mg, 95.0percent Yield): 1H NMR (CDCl3, 500 MHz) d 7.49 (d, 1H, J = 7.01 Hz, Ar-H), 7.47 (s, 1H, Ar-H), 6.68 (d, 1H, J = 7.01 Hz, Ar-H), 3.87 (s, 3H, -COOCH3), 3.80 (brs, 2H, -NH2), 3.35 (brs, 2H, -NH2); 13C NMR (CDCl3, 125 MHz) d 166.56, 140.89, 138.16, 120.87, 118.23, 118,16, 52.11; LCMS m/z calcd for (MNa)+ 189.06, found 189.00.
94% for 11 h; Reflux 3,4-diaminobenzoic acid (2 g, 13.14 mmol) was converted into 3,4-methyl diaminobenzoate 2 (2.04 g, 12.27 mmol, 94percent yield) using thionyl chloride (1.24 mL, 17.1 mmol) with a MeOH reflux during 11 h. In parallel, a solution of 3-methoxycatechol (2 g, 14.27 mmol) was oxidized by the drop by drop addition of a o-chloranil solution (3.65 g, 14.84 mmol) in anhydrous Et2O at −20° C. during 15 minutes to obtain by filtration 3-methoxy-[1,2]benzoquinone 1 (1.56 g, 11.29 mmol, 79percent yield) as a dark green solid. The solid was washed with Et2O and the final residue obtained (700 mg, 5.06 mmol) was immediately redissolved in CH2Cl2 (30 mL) and it was added drop by drop to a solution of methyl ester 2 (660 mg, 3.97 mmol) in the same solvent (10 mL) slightly acidified with acetic acid (5 drops). After stirring during 1.5 h at a.t., the solution was diluted with water (20 mL) and was extracted with CH2Cl2 (10 mL), it was dried (Mg2SO4) and the solvent was vacuum eliminated. The product was purified using silica gel chromatography in a mobile phase of 1:1 EtOAc:hexane to produce the desired compound in the form of a mixture of isomers in the form of a yellow solid (110 mg, 41percent yield). Maj is majority product and Min minority product.
91% at 0℃; for 3 h; Inert atmosphere; Reflux H2SO4 (6 mL,113 mmol) was slowly added dropwise at 0 °C to a solution of 3,4-diaminobenzoic acid (3 g, 19.7 mmol) in methanol (60 mL) with stirring; then, the mixture heated at reflux for 3 h. Saturated solution of NaHCO3 was added until the mixture was basic; then, the mixture was extracted with DCM. The extract was dried and evaporated in vacuum to give the product 4 (2.98 g, 91 percent) as a brown crystalline solid. 1H NMR (300 MHz, CDCl3) δ 7.46 (dd,J = 8.1, 1.8 Hz, 1H), 7.41 (d, J = 1.8 Hz, 1H), 6.67 (d,J = 8.1 Hz, 1H), 3.85 (s, 3H), 3.53 (s, 4H).
81% at 20℃; for 3 h; Heating / reflux A) Methyl-3,4-diaminobenzoate; To dry methanol (20 ml) was carefully added thionyl chloride (1 ml) dropwise with stirring. The 3,4-diaminobenzoic acid (1 g) was added in portions at R.T. with' stirring then the mixture heated at reflux for 3 h. Saturated sodium bicarbonate was added until the mixture was basic, then the mixture extracted into chloroform containing 25percent methanol. The extract was dried and evaporated in vacuo to give the product (0.88 g, 81percent) as a brown crystalline solid. 1H NMR (CDC13) 7.46 (1H, dd, J 2,8Hz), 7.40(1H, d, J 2Hz), 6.67 (1H, d, J 8Hz) and 3.84 (3H, s).
79% at 0 - 80℃; Thionyl chloride (13.0 ml, 180 mmol) was slowly added dropwise at 0°C to a solution of 3,4-diaminobenzoic acid (25.0 g, 164 mmol) in methanol (164 ml). After stirring the mixture at room temperature overnight, it was further stirred at 80°C overnight. The reaction mixture was cooled to room temperature, and the precipitated solid was filtered out and washed with methanol. The filtrate was concentrated under reduced pressure and the obtained solid was filtered out and washed with methanol. All of the obtained solid was dried under reduced pressure at 60°C to obtain 3,4-diaminobenzoic acid methyl ester. The compound was identified by NMR. Yield: 31.16 g (79percent).1H-NMR (270 MHz, CDCl3): 3.76(s,3H), 6.85(d,1H,J=8.6Hz), 7.63(dd,1H,J=1.9,8.6Hz), 7.78(d,1H,J=1.9Hz).
78% for 24 h; Reflux To a solution of 3,4-diaminobenzoic acid (10.0g, 0.07mol) and 200mL of MeOH, sulfuric acid (30mL) was added dropwise. After refluxing for 24h, the solution was cooled to room temperature. The organic solvent was removed with reduced pressure. The crude product was neutralized by aqueous K2CO3 then extracted by ethyl acetate/H2O. The organic layers were collect and the solvent was evaporated to dryness. The products isolated as brown powder was obtained after recrystallization from MeOH. Yield: 78percent. 1H NMR (300MHz, CDCl3): δ 3.52 (s, 4H, NH2), 3.82 (s, 3H, −CH3), 6.64 (d, 1H, Ar−H, J=8.1Hz), 7.38 (d, 1H, Ar−H, J=1.8Hz), 7.44 (d, 1H, Ar−H, J=9.9Hz). 13C NMR (75MHz, DMSO): δ 51.62, 114.86, 118.31, 121.03, 123.22, 133.08, 140.39, 167.33
75.5% for 18 h; Inert atmosphere; Reflux 3, 4-Diaminobenzoic acid (9) (2 g, 0.014 mol) was added to dry methanol (50 mL) under nitrogen. The mixture was cooled and cone. H2S04 added (2 mL). The resulting solution was then refluxed for 18 hours. After this time, the solution was cooled and washed with sodium hydrogen carbonate 10 percent (40 mL). The solution was transferred to a separating funnel and ethyl acetate added (40 mL). The aqueous layer was further extracted with ethyl acetate (3 χ 20 mL). The combined organic layers were washed with sodium hydrogen carbonate 5 percent (20 mL) and dried (MgS04). The solvent was removed in vacuo to afford a brown solid which was purified by recrystallisation from petroleum ether (40/60): ethyl acetate to yield methyl 3, 4-diaminobenzoate (10) as brown needles (1.65 g, 75.5 percent); mp 105 °C; Rf = 0.47 (ethyl acetate); mlz 167.0 (MH+); vmax (KBr) / cm"1 1705 (CO), 1267 (C-O); δΗ (d6-DMSO, 300 MHz) 7.16 (1 H, d, J2, 6 = 2.0, H2), 7.10 (1 H, dd, 6, 5 = 8.1 , J6, 2 = 2.0, H6), 6.51 (1 H, d, s, 6 = 8.1 , H5), 5.28 (2H, s, NH2), 4.66 (2H, s, NH2), 3.71 (3H, s, OCH3); 5C (d6- DMSO, 75 MHz), 167.3 (CO), 141.0 (C4), 134.3 (C3), 120.7 (C6), 117.6 (d), 1 15.3 (C2), 113.1 (C5), 51.5 (OCH3).
75% for 3 h; Reflux [0415j Step A: Preparation of methyl 3,4-diaminobenzoate: To a solution of 3,4- diaminobenzoic acid (2.2 g, 14.5 mmol) in MeOH (50 ml) was added concentrated sulfuric acid (1 mL) and the mixture was stirred at reflux for 3 hours. After cooling to ambient temperature, the solvent removed under reduced pressure. Saturated sodium bicarbonate and ethyl acetate were added. The organic layer was separated, washed with brine, dried (sodium sulfate), filtered and concentrated under reduced pressure to give methyl 3,4- diaminobenzoate (1.8 g, 75percent) as solid.
55% for 12 h; Heating / reflux Thionyl chloride (16.0 mL, 220 mmol) was added to a suspension of 3,4-diamino- benzoic acid (16.8 g, 110 mmol) in dry MeOH (200 mL). The resulting mixture was heated at reflux. After 12h, the solution was successively cooled down to room temperature and concentrated under reduced pressure. The residue was triturated in diluted NaHCO3. Then, the precipitate was filtered off and dried to give 10.1 g (55 percent) of the target compound 1007.

Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 24, p. 7456 - 7460
[2] Patent: US2016/33489, 2016, A1, . Location in patent: Paragraph 0204
[3] Medicinal Chemistry Research, 2015, vol. 24, # 8, p. 3143 - 3156
[4] Patent: WO2005/113489, 2005, A1, . Location in patent: Page/Page column 75-76
[5] Patent: EP1502916, 2005, A1, . Location in patent: Page 440
[6] Tetrahedron, 2016, vol. 72, # 41, p. 6321 - 6333
[7] European Journal of Medicinal Chemistry, 2004, vol. 39, # 3, p. 291 - 298
[8] Patent: WO2014/96864, 2014, A1, . Location in patent: Paragraph 00176
[9] Patent: WO2015/175845, 2015, A1, . Location in patent: Paragraph 0415
[10] Chemistry - A European Journal, 2005, vol. 11, # 1, p. 112 - 119
[11] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 11, p. 2487 - 2497
[12] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 6, p. 1767 - 1773
[13] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6714 - 6723
[14] Patent: WO2007/26024, 2007, A2, . Location in patent: Page/Page column 61
[15] Patent: DE151725, , ,
[16] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 11, p. 2791 - 2795
[17] Patent: WO2010/43711, 2010, A1, . Location in patent: Page/Page column 59
[18] Patent: US2012/46307, 2012, A1, . Location in patent: Page/Page column 28
[19] Bulletin of the Korean Chemical Society, 2013, vol. 34, # 8, p. 2297 - 2304
[20] Bioorganic Chemistry, 2015, vol. 63, p. 72 - 84
[21] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 234 - 245
  • 8
  • [ 99512-09-1 ]
  • [ 36692-49-6 ]
YieldReaction ConditionsOperation in experiment
96.7% With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 4 h; Inert atmosphere The 6.1g4- amino-3-nitrobenzoate was dissolved in 100mL of methanol, the replacement N2And stirred under N2Join atmosphere 0.6g10percent palladium on carbon, replacement H2, The reaction at room temperature for 4h, the reaction was filtered through celite and the filtrate was spin-dry the solvent gave a dark purple viscous oil liquid 5g.Yield 96.7percent.
Reference: [1] Patent: CN103864753, 2016, B, . Location in patent: Paragraph 0059; 0060-0061
  • 9
  • [ 619-05-6 ]
  • [ 36692-49-6 ]
YieldReaction ConditionsOperation in experiment
93% With sodium hydroxide; thionyl chloride; sodium chloride In methanol; dichloromethane Referential Preparation 1
Methyl 3,4-diaminobenzoate
3,4-Diaminobenzoic acid (3.0 g) was suspended in methanol, followed by the dropwise addition of 1.86 ml of thionyl chloride.
Thionyl chloride was added twice, in an amount of 0.5 ml each time, and the resulting mixture was heated under reflux for 10 hours and 40 minutes.
The thionyl chloride and methanol were distilled out, followed by the dissolution of the residue in methylene chloride.
The solution so formed was washed with a 0.5N aqueous solution of sodium hydroxide and then with a saturated aqueous solution of sodium chloride, and was dried over sodium sulfate.
The solvent was distilled out.
The residue was washed with n-hexane and then dried, whereby 3.04 g of the target compound were obtained (yield: 93percent).
Reference: [1] Patent: US5852011, 1998, A,
[2] Patent: US5821258, 1998, A,
  • 10
  • [ 3987-92-6 ]
  • [ 36692-49-6 ]
Reference: [1] Journal of the Chemical Society, 1957, p. 2197,2199
[2] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 1106 - 1109
[3] Chinese Chemical Letters, 2017, vol. 28, # 4, p. 919 - 926
  • 11
  • [ 22907-68-2 ]
  • [ 36692-49-6 ]
Reference: [1] Heterocycles, 1991, vol. 32, # 11, p. 2093 - 2097
[2] Patent: US6660742, 2003, B2, . Location in patent: Page column 35
  • 12
  • [ 1588-83-6 ]
  • [ 36692-49-6 ]
Reference: [1] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 1106 - 1109
[2] Patent: DE151725, , ,
[3] Chinese Chemical Letters, 2017, vol. 28, # 4, p. 919 - 926
  • 13
  • [ 528-45-0 ]
  • [ 36692-49-6 ]
Reference: [1] Heterocycles, 1991, vol. 32, # 11, p. 2093 - 2097
  • 14
  • [ 1539-06-6 ]
  • [ 36692-49-6 ]
Reference: [1] Patent: DE151725, , ,
  • 15
  • [ 506-68-3 ]
  • [ 36692-49-6 ]
  • [ 106429-38-3 ]
Reference: [1] Angewandte Chemie - International Edition, 2012, vol. 51, # 21, p. 5226 - 5229
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 2, p. 663 - 674
[3] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 5, p. 1487 - 1496
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 11, p. 2842 - 2845
  • 16
  • [ 36692-49-6 ]
  • [ 95-92-1 ]
  • [ 354793-04-7 ]
YieldReaction ConditionsOperation in experiment
90% for 88 h; Reflux Condensation of methyl 3 ,4-diaminobenzoate with diethyl oxalate (8.0 equivalents) in toluene (10 volumes) was carried out at reflux for 88 hours. After complete conversion, the mixture was concentrated to a residue which was washed with MTBE. After drying intermediate 184 was obtained in 90percent yield.
90% for 88 h; Reflux Condensation of methyl 3,4-diaminobenzoate with diethyl oxalate (8.0 equivalents) in toluene (10 volumes) was carried out at reflux for 88 hours. After complete conversion, the mixture was concentrated to a residue which was washed with methyl tert-butyl ether. After drying intermediate 25 was obtained in 90percent yield.
Reference: [1] Patent: WO2017/60406, 2017, A1, . Location in patent: Page/Page column 172
[2] Patent: WO2018/178280, 2018, A1, . Location in patent: Page/Page column 78
[3] Patent: US2004/192698, 2004, A1, . Location in patent: Page/Page column 18
  • 17
  • [ 124-38-9 ]
  • [ 36692-49-6 ]
  • [ 616224-38-5 ]
Reference: [1] Angewandte Chemie - International Edition, 2013, vol. 52, # 46, p. 12156 - 12160[2] Angew. Chem., 2013, vol. 125, # 46, p. 12378 - 12382,5
  • 18
  • [ 36692-49-6 ]
  • [ 1368310-81-9 ]
Reference: [1] Patent: US2012/108619, 2012, A1,
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 36692-49-6 ]

Aryls

Chemical Structure| 619-45-4

[ 619-45-4 ]

Methyl 4-aminobenzoate

Similarity: 0.96

Chemical Structure| 18595-12-5

[ 18595-12-5 ]

Methyl 5-amino-2-methylbenzoate

Similarity: 0.94

Chemical Structure| 4518-10-9

[ 4518-10-9 ]

Methyl 3-aminobenzoate

Similarity: 0.94

Chemical Structure| 99-27-4

[ 99-27-4 ]

Dimethyl 5-aminoisophthalate

Similarity: 0.94

Chemical Structure| 6933-47-7

[ 6933-47-7 ]

Methyl 4-amino-2-methylbenzoate

Similarity: 0.94

Esters

Chemical Structure| 619-45-4

[ 619-45-4 ]

Methyl 4-aminobenzoate

Similarity: 0.96

Chemical Structure| 18595-12-5

[ 18595-12-5 ]

Methyl 5-amino-2-methylbenzoate

Similarity: 0.94

Chemical Structure| 4518-10-9

[ 4518-10-9 ]

Methyl 3-aminobenzoate

Similarity: 0.94

Chemical Structure| 99-27-4

[ 99-27-4 ]

Dimethyl 5-aminoisophthalate

Similarity: 0.94

Chemical Structure| 6933-47-7

[ 6933-47-7 ]

Methyl 4-amino-2-methylbenzoate

Similarity: 0.94

Amines

Chemical Structure| 619-45-4

[ 619-45-4 ]

Methyl 4-aminobenzoate

Similarity: 0.96

Chemical Structure| 18595-12-5

[ 18595-12-5 ]

Methyl 5-amino-2-methylbenzoate

Similarity: 0.94

Chemical Structure| 4518-10-9

[ 4518-10-9 ]

Methyl 3-aminobenzoate

Similarity: 0.94

Chemical Structure| 99-27-4

[ 99-27-4 ]

Dimethyl 5-aminoisophthalate

Similarity: 0.94

Chemical Structure| 6933-47-7

[ 6933-47-7 ]

Methyl 4-amino-2-methylbenzoate

Similarity: 0.94