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Chemical Structure| 371251-07-9 Chemical Structure| 371251-07-9

Structure of 371251-07-9

Chemical Structure| 371251-07-9

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Product Details of [ 371251-07-9 ]

CAS No. :371251-07-9
Formula : C10H12BrN
M.W : 226.11
SMILES Code : CNC1CCC2=C1C=C(Br)C=C2
MDL No. :MFCD11219796

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Application In Synthesis of [ 371251-07-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 371251-07-9 ]

[ 371251-07-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 371251-07-9 ]
  • [ 32315-10-9 ]
  • [ 60211-57-6 ]
  • 3,5-dichlorobenzyl (6-bromo-2,3-dihydro-1H-inden-1-yl)(methyl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
DIPEA (2.06 g, 15.93 mmol) and triphosgene (1.89 g, 6.37 mmol) were added to a solution of <strong>[60211-57-6]3,5-dichlorobenzyl alcohol</strong> (2.82 g, 15.93 mmol) in DCM (100 mL) at 0C . The reaction mixture was stirred at the same temperature for 30 minutes. After the <strong>[60211-57-6]3,5-dichlorobenzyl alcohol</strong> was consumed, a solution of Compound 2 (6- bromo-N-methyl-2,3-dihydro-lH-inden-l -amine) (3.00 g, 13.27 mmol) and DIPEA (2.06 g, 15.93 mmol) in DCM (30 mL) was added into the reaction mixture. Then the reaction mixture was slowly warmed to room temperature and stirred overnight. After the reaction was completed, the solvent in the reaction mixture was removed under reduced pressure. The residue was diluted with saturated NH4Cl and extracted with EtOAc, and then resulting organic layers were combined. The combined organic layers were dried over MgS04 and concentrated in vacuo to obtain a crude product. The crude product was used as Compound 4 in the next step without further purification, and the yield thereof was 5.06 g (1 1.79 mmol).
 

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