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[ CAS No. 3723-70-4 ]

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2D
Chemical Structure| 3723-70-4
Chemical Structure| 3723-70-4
Structure of 3723-70-4 *Storage: {[proInfo.prStorage]}

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Alternatived Products of [ 3723-70-4 ]

Product Details of [ 3723-70-4 ]

CAS No. :3723-70-4MDL No. :MFCD00499525
Formula : C12H11N3O2 Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :229.24Pubchem ID :-
Synonyms :

Computed Properties of [ 3723-70-4 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 3723-70-4 ]

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Application In Synthesis of [ 3723-70-4 ]

  • Downstream synthetic route of [ 3723-70-4 ]

[ 3723-70-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5470-18-8 ]
  • [ 100-46-9 ]
  • [ 3723-70-4 ]
YieldReaction ConditionsOperation in experiment
98% With N-ethyl-N,N-diisopropylamine; In ethanol;Inert atmosphere; Autoclave; General procedure: To a stirred solution of chloro nitro pyridine / pyrimidine (1.0 equiv) in EtOH (0.5 mL per 0.52 mmol) was added DIPEA (3.0 equiv) followed by amine (1.05 equiv) at 0oC. The reaction mixture was stirred at 60-80oC for 3-6 h (the reaction was monitored by TLC). After completion of the reaction EtOH was distilled-off under a reduced pressure. The residue was dissolved in EtOAc (50 mL per 1g of crude). The organic layer was washed with water (20 mL), and brine (20 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The resultant crude compound was purified by silica gel column chromatography (100-200 mesh) using 10-20 % ethyl acetate - hexane to afford the desired compound (yield: 85-95 %).
59% In N,N-dimethyl-formamide; at 110.0℃; for 5.0h; A mixture of compound 1 (1.58 g, 10 mmol) and benzylamine (1.07 g, 10 mmol) in DMF (1 ml) was heated for 5 h at 110 C. The allowed to cool, and water was added. The resultant yellow precipitate was filtered off, washed with water, and crystallized from ethanol. Yield 1.35 g (59 %). Mp 80-81C (mp 78C (EtOH)28).
With caesium carbonate; In methanol;Reflux; General procedure: Commercially available 2-chloro-3-nitro-pyridine of general formula F-1 was reacted with Cs2C03 and the required Amine 1 in methanol at reflux to yield the aralkyl-(3- nitro-pyridin-2-yl)-amine derivatives of general formula F-2, which was hydrogenated over Pd/C in EtOH to afford N'2'-aralkyl-pyridine-2,3-diamine of general formula F-3. This diamine could alternatively be obtained through a reduction with iron in HCI. Intermediate F-3 was reacted with succinic anhydride in dioxane at reflux, and then treated with H2S04 and EtOH under reflux. The obtained ester, of general formula F-4, was treated with K'OBu and the required Amine 2 in the MW at 150 C to afford the final compounds of general formula F-5.
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