Home Cart 0 Sign in  

[ CAS No. 3723-70-4 ]

{[proInfo.proName]}
Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 3723-70-4
Chemical Structure| 3723-70-4
Structure of 3723-70-4 *Storage: {[proInfo.prStorage]}

Quality Control of [ 3723-70-4 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 3723-70-4 ]

SDS

Product Details of [ 3723-70-4 ]

CAS No. :3723-70-4MDL No. :MFCD00499525
Formula :C12H11N3O2Boiling Point :-
Linear Structure Formula :-InChI Key :-
M.W :229.24Pubchem ID :-
Synonyms :

Computed Properties of [ 3723-70-4 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 3723-70-4 ]

Signal Word:Class
Precautionary Statements:UN#:
Hazard Statements:Packing Group:

Application In Synthesis of [ 3723-70-4 ]

  • Downstream synthetic route of [ 3723-70-4 ]

[ 3723-70-4 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 3723-70-4 ]
  • [ 106-95-6 ]
  • 1-allyloxy-2-phenyl-1<i>H</i>-imidazo[4,5-<i>b</i>]pyridine [ No CAS ]
  • 2
  • [ 109-65-9 ]
  • [ 3723-70-4 ]
  • 1-butoxy-2-phenyl-1<i>H</i>-imidazo[4,5-<i>b</i>]pyridine [ No CAS ]
  • 3
  • [ 2746-25-0 ]
  • [ 3723-70-4 ]
  • 1-(4-methoxy-benzyloxy)-2-phenyl-1<i>H</i>-imidazo[4,5-<i>b</i>]pyridine [ No CAS ]
  • 4
  • [ 100-39-0 ]
  • [ 3723-70-4 ]
  • 1-(benzyloxy)-2-phenyl-1H-imidazo[4,5-b]pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Step a) Benzyl-(3-nitro-pyridin-2-yl)-amine To a stirred solution of 2-chloro-3-nitropyridine (10 g, 63.1 mmol) in toluene (100 mL) was added in one portion benzyl amine (13.5 g, 126 mmol) and set to reflux overnight. The reaction was cooled to room temperature and filtered. The solvent was evaporated and the residue was purified by flash chromatography (10% EtOAc/petroleum ether) affording the title compound as a yellow solid, mp 78 C; MSm/e 229 (M+). Analysis for C12H11N3O2: Calcd. C, 62.87; H, 4.84; N, 18.33. Found: C, 63.15; H, 4.74; N, 18.28.
Step a) Benzyl-(3-nitro-pyridin-2-yl)-amine To a stirred solution of 2-chloro-3-nitropyridine (10 g, 63.1 mmol) in toluene (100 mL) was added in one portion benzyl amine (13.5 g, 126 mmol) and set to reflux overnight. The reaction was cooled to room temperature and filtered. The solvent was evaporated and the residue was purified by flash chromatography (10% EtOAc/petroleum ether) affording the title compound as a yellow solid, mp 78 C.; MS m/e 229 (M+). Analysis for C12H11N3O2: Calcd. C, 62.87; H, 4.84; N, 18.33. Found: C, 63.15; H, 4.74; N, 18.28.
  • 7
  • [ 5470-18-8 ]
  • [ 140-75-0 ]
  • [ 3723-70-4 ]
YieldReaction ConditionsOperation in experiment
94% With caesium carbonate; In 1,4-dioxane; at 100.0℃; for 2.0h; In a round bottom flask fitted with magnetic stirrerand reflux condenser, a solution of 2-chloro-3-nitropyridine, 8, (1.0 g, 6.3 mmol) and Cs2CO3 (4.0 g, 12 mmol) in dioxane (20 mL) was added the appropriate benzyl amine and heated at 100 C for2 h. The mixture was cooled to rt, filtered and purified by column chromatography (Biotage) witha gradient of EtOAc and hexanes (0-20%EtOAc in Hexane) to provide desired compound (1.37g,94%).
  • 8
  • [ 3723-70-4 ]
  • 3-benzyl-N-(furan-2-ylmethyl)-3H-imidazo[4,5-b]pyridin-2-amine [ No CAS ]
  • 9
  • [ 3723-70-4 ]
  • 3-(3-benzyl-3H-imidazo[4,5-b]pyridin-2-yl)-N-(thiophen-2-ylmethyl)-propionamide [ No CAS ]
  • 10
  • [ 3723-70-4 ]
  • 3-(3-benzyl-3H-imidazo[4,5-b]pyridin-2-yl)-N-((S)-1-phenyl-ethyl)-propionamide [ No CAS ]
Historical Records