Home Cart 0 Sign in  

[ CAS No. 374063-90-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 374063-90-8
Chemical Structure| 374063-90-8
Structure of 374063-90-8 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 374063-90-8 ]

Related Doc. of [ 374063-90-8 ]

Alternatived Products of [ 374063-90-8 ]
Product Citations

Product Details of [ 374063-90-8 ]

CAS No. :374063-90-8 MDL No. :MFCD03307787
Formula : C9H8O5 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 196.16 Pubchem ID :-
Synonyms :

Safety of [ 374063-90-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501 UN#:N/A
Hazard Statements:H315-H319-H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 374063-90-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 374063-90-8 ]

[ 374063-90-8 ] Synthesis Path-Downstream   1~12

  • 1
  • [ 374063-90-8 ]
  • [ 3829-80-9 ]
  • [ 100-52-7 ]
  • C21H16N2O6S [ No CAS ]
  • 2
  • [ 374063-90-8 ]
  • [ 28466-21-9 ]
  • [ 100-52-7 ]
  • C21H19N3O4 [ No CAS ]
  • 3
  • [ 374063-90-8 ]
  • [ 2289-75-0 ]
  • [ 100-52-7 ]
  • C20H16N2O4S [ No CAS ]
  • 4
  • [ 374063-90-8 ]
  • [ 17647-70-0 ]
  • [ 100-52-7 ]
  • C18H13N3O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: methyl 4-(furan-2-yl)-2,4-dioxobutanoate; 3-amino-4-methylfurazan; benzaldehyde With chloro-trimethyl-silane In N,N-dimethyl-formamide Sealed tube; Heating; Stage #2: With water In N,N-dimethyl-formamide at 20℃; for 2h; Sonication;
  • 5
  • [ 374063-90-8 ]
  • [ 93-85-6 ]
  • [ 100-52-7 ]
  • [ 1055126-64-1 ]
  • 6
  • [ 374063-90-8 ]
  • [ 3829-80-9 ]
  • [ 123-11-5 ]
  • C22H18N2O7S [ No CAS ]
  • 7
  • [ 374063-90-8 ]
  • [ 28466-21-9 ]
  • [ 123-11-5 ]
  • C22H21N3O5 [ No CAS ]
  • 8
  • [ 374063-90-8 ]
  • [ 2289-75-0 ]
  • [ 123-11-5 ]
  • C21H18N2O5S [ No CAS ]
  • 9
  • [ 374063-90-8 ]
  • [ 17647-70-0 ]
  • [ 123-11-5 ]
  • C19H15N3O6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: methyl 4-(furan-2-yl)-2,4-dioxobutanoate; 3-amino-4-methylfurazan; 4-methoxy-benzaldehyde With acetic acid Reflux; Stage #2: With water at 20℃; for 2h; Sonication;
  • 10
  • [ 374063-90-8 ]
  • [ 93-85-6 ]
  • [ 123-11-5 ]
  • [ 1054502-27-0 ]
  • 11
  • [ 374063-90-8 ]
  • [ 106-49-0 ]
  • [ 27258-33-9 ]
  • C20H17N3O4 [ No CAS ]
  • 12
  • [ 553-90-2 ]
  • [ 1192-62-7 ]
  • [ 374063-90-8 ]
YieldReaction ConditionsOperation in experiment
89.9% Stage #1: 1-(2-furyl)-1-ethanone With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Stage #2: Dimethyl oxalate In tetrahydrofuran at -78 - 20℃; 2.1 Synthesis of methyl 4-(furan-2-yl)-2,4-dioxobutanoate (5) To a stirred solution of compound 4 (5 g, 45.0 mmol) in THF (100 mL) at -78 °C, LiHMDS (58.5 mL, 58.5 mmol) was added drop wise. After 30 min, a solution of dimethyl oxalate (7.9 g, 67.5 mmol) in THF (20 mL) was added. The reaction mixture was allowed to attain the room temperature in cooling bath gradually and stirred overnight. Solvent was removed, water (100 mL) added, extracted with ethyl acetate (50 mL X 3). Combined organic layer was washed with brine, dried over sodium sulphate and concentrated to afford the title compound 5 (8.0 g, 89.9%>) which was used for further reaction
Stage #1: 1-(2-furyl)-1-ethanone With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; Stage #2: Dimethyl oxalate In tetrahydrofuran at 20℃; Inert atmosphere; General procedure: Method A To a stirred solution of 1 equivalent of methyl ketone (I-1), in dry THF (10 volumes per gram of methyl ketone) at -78 °C under an Argon atmosphere, was added lithium hexamethyldisilazide (1M in THF, 1.3 eq.). The mixture was stirred for 1 h, following which dimethyl oxalate (1.5 eq.) dissolved in dry THF (5 volumes per gram of dimethyl oxalate) was added dropwise and the resulting reaction mixture stirred at room temperature overnight. After completion, the mixture was concentrated under reduced pressure. The residue was diluted with water and the resulting was collected by filtration. The solid was washed with ethyl acetate followed by diethyl ether and dried under reduced pressure. The resulting diketoester (I-3) was used in the next step without further purification.
Recommend Products
Same Skeleton Products
Historical Records