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[ CAS No. 374105-86-9 ] {[proInfo.proName]}

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Chemical Structure| 374105-86-9
Chemical Structure| 374105-86-9
Structure of 374105-86-9 * Storage: {[proInfo.prStorage]}
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Product Details of [ 374105-86-9 ]

CAS No. :374105-86-9 MDL No. :MFCD02093067
Formula : C9H9BO4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 191.98 Pubchem ID :-
Synonyms :

Safety of [ 374105-86-9 ]

Signal Word:Warning Class:
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 UN#:
Hazard Statements:H302-H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 374105-86-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 374105-86-9 ]

[ 374105-86-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 374105-86-9 ]
  • [ 717107-32-9 ]
YieldReaction ConditionsOperation in experiment
85% With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 5h;
70% With hydrogen In methanol at 20℃; for 3h; 24 Example 24 Synthesis OF 3-{2-[4-(3,5-dichloro-pyridin-4-ylmethyl)-7-methoxy-phthalazin-1-yl]-phenyl}-propionic acid (compound 14) Example 24 Synthesis OF 3-{2-[4-(3,5-dichloro-pyridin-4-ylmethyl)-7-methoxy-phthalazin-1-yl]-phenyl}-propionic acid (compound 14) A suspension of 2- (2-carboxy-vinyl)-phenylboronic acid (50 mg, 0.25 mmol) and 10% Pd on charcoal (5 mg) in methanol was stirred under hydrogen atmosphere (20 psi) at room temperature for 3 hours. The catalyst was filtered off through celite and the solvent was evaporated in vacuo to give the 2- (2-carboxy-ethyl)-phenylboronic acid (35 mg, 0.18 mmol, 70% yield). Compound 14 was synthesized by Suzuki coupling of intermediate 1 (58 mg, 0.16 mmol, 1 eq. ) and the previously prepared boronic acid (35 mg, 0.18 mmol, 1.1 eq. ) according to what is described in E XAMPLE 17. A FTER E VAPORATION o f the s olvent the product was purified by flash chromatography eluting with dichloromethane, methanol and 50% aqueous solution of formic acid (95: 5: 0.5) to afford compound 14 (12 mg, 0.02 mmol, 16% yield). [M+H] + 468 HPLC/MS: Gilson instrument equipped with a C18 column Zorbax SBC18 (3. 5, UM, 2.1 x 50 mm) coupled with a diode array UV detector (220 nm) and a Finnigan Aqa mass spectrometer (electron spray, positive ionization). The following settings were used: flow rate: 1 mL/min; column temperature: 40°C ; gradient elution A/B (eluent A: 0.5% formic acid in water; eluent B: 0.5% formic acid in acetonitrile); t = 0 min. , A/B = 95: 5, t = 8 min. , A/B = 5 : 95; RT 4. 47 MIN.
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