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CAS No. : | 374538-01-9 | MDL No. : | MFCD02093074 |
Formula : | C7H6BFO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | YABSTJQEBSKPCG-UHFFFAOYSA-N |
M.W : | 167.93 | Pubchem ID : | 2778651 |
Synonyms : |
|
Num. heavy atoms : | 12 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.0 |
Num. rotatable bonds : | 2 |
Num. H-bond acceptors : | 4.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 41.61 |
TPSA : | 57.53 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -7.05 cm/s |
Log Po/w (iLOGP) : | 0.0 |
Log Po/w (XLOGP3) : | 0.39 |
Log Po/w (WLOGP) : | -0.26 |
Log Po/w (MLOGP) : | 0.08 |
Log Po/w (SILICOS-IT) : | -0.16 |
Consensus Log Po/w : | 0.01 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -1.36 |
Solubility : | 7.25 mg/ml ; 0.0432 mol/l |
Class : | Very soluble |
Log S (Ali) : | -1.16 |
Solubility : | 11.5 mg/ml ; 0.0685 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -1.51 |
Solubility : | 5.2 mg/ml ; 0.031 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 2.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.74 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
79% | With sodium carbonate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In water; toluene; for 5h;Heating / reflux; | To a solution of the compound of Referential example 5 (1.79g, 5.00mmol) in toluene (50mL) were added 4-fluoro-3- formylphenylboric acid (1.01g, 6.00mmol), 2mol/L aqueous solution of sodium carbonate (5.00mL, 10.0mmol) and [1,1'- bis(diphenylphosphino)ferrocene] dichloropalladium(II)- dichloromethane(1:1) complex (204mg, 250 mumol), and the mixture was refluxed for 5 hours. After cooling, the organic layer was separated, dried over anhydrous sodium sulfate, and then solvent was distilled off. The residue obtained was purified by silica gel column chromatography [hexane:ethyl acetate=4:1], thereby affording 1.58g of the title compound as colorless powder. Yield 79%.1H-NMR (DMSO-d6, delta): 4.14(3H,s), 7.07(1H,dd,J=7.9,10.4Hz), 7.40 (2H,t,J=7.9Hz), 7.54-7.69(6H,m), 7.77-7.80(2H,m), 8.32(1H,d,J=8.6 Hz), 9.92(1H,s). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium phosphate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; at 80℃; for 8h; | A mixture of <strong>[374538-01-9]4-fluoro-3-formylphenylboronic acid</strong> (0.34 g, 2.0 mmol), 7-memoxy-2-oxo-2H-chromen- 4-yl trifluoromethanesulfonate (0.62 g, 2.0 mmol), K3PO4 (1.3 g, 6.0 mmol) and Pd(PPh3)4 (0.2 mmol) in dioxane (10 mL) was stirred at 80 0C for 8 h. The mixture was diluted with diethyl ether (50 mL) and filtered through a pad of silica gel. The filtrate was concentrated and the residue was purified by chromatography on silica gel to give the title compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | Synthesis of Compound 419:; 3-[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-fluoro-benzene boronic acid (247); To a solution of <strong>[374538-01-9]4-fluoro-3-formyl benzene boronic acid</strong> (0.88g, 5.99 mmol) in THF (5 mL) and toluene (5 mL) was added amine (3) (1.4 g, 7.19 mmol) followed by AcOH (0.34 mL, 7.19 mmol), and the resulting solution was stirred at RT for 18 h. After this time sodium triacetoxyborohydride (1.57 g, 8.38 mmol) was added and the resulting solution was stirred at RT for a further 6 h. EtOAc (10 mL) was added to the reaction mixture followed by dropwise addition of sat. NaHCO3 solution (10 mL). The organic layer was separated and the aqueous layer was extracted into EtOAc (2 x 10 mL). The combined organic layers were dried (MgSO4), filtered and reduced in vacuo to give the title compound as a yellow solid. EPO <DP n="396"/>Yield: 1.6 g (80%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | 3-[4-(BOC-methyl-amino)-cyclohexylamino]-methyl}-4-fluoro-benzene boronic acid (247); To a solution of <strong>[374538-01-9]4-fluoro-3-formyl benzene boronic acid</strong> (0.88g, 5.99 mmol) in THF (5 mL) and toluene (5 mL) was added amine (3) (1.4 g, 7.19 mmol) followed by AcOH (0.34 mL, 7.19 mmol), and the resulting solution was stirred at RT for 18 h. After this time sodium triacetoxyborohydride (1.57 g, 8.38 mmol) was added and the resulting solution was stirred at RT for a further 6 h. EtOAc (10 mL) was added to the reaction mixture followed by dropwise addition of sat. NaHCO3 solution (10 mL). The organic layer was separated and the aqueous layer was extracted into EtOAc (2 x 10 mL). The combined organic layers were dried (MgSO4), filtered and reduced in vacuo to give the title compound as a yellow solid. EPO <DP n="396"/>Yield: 1.6 g (80%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
~ 50% | With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80℃; for 6 - 10h; | Tris(dibenzylideneacetone)palladium(0) (0.025 equiv.) was added in argon to a 1,4-dioxane sol. of the quinazoline compound (1 equiv.), boric acid (1.2 equiv.), cesium carbonate (2.5 equiv.) and Xanthpos (0.075 equiv.), and the mixture heated 6-10 h to 80 C. When the complete conversion of the bromine compound (LCMS) had been achieved, the mixture was filtered over celite and washed with EE. The filtrate was washed with water and brine, dried (Na2SO4) and evaporated to low bulk. The raw product was purified by column chromatography (approx. 30% EE in DCM). (Yield approx. 50%) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; toluene; at 75℃; for 18h; | iv)-To a solution of the product obtained in the previous step (0.5 g, 1.62 mmol) in toluene/ethanol (4/1; 25 ml) were added <strong>[374538-01-9]4-fluoro-3-formylphenylboronic acid</strong> (0.41 g, 2.43 mmol), (Ph3P)4Pd (93.6 mg, 0.081 mmol) and potassium carbonate (6.3 ml 2M, 12.5 mmol). After 18 h stirring at 75 C. the reaction mixture was cooled and filtered over dicalite. The product was extracted into ethyl acetate. The combined organic phases were washed with water, brine, dried over magnesium sulfate and concentrated under reduced pressure. Column chromatography afforded 4'-(3-cyclopropyl-2,4-dioxo-imidazolidin-1-ylmethyl)-4-fluoro-biphenyl-3-carbaldehyde (0.28 g) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With potassium phosphate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In 1,4-dioxane; water; at 110℃; for 4h;Inert atmosphere; | Example 356 6- {3-[(Dimethylamino)methyl]-4-fluorophenyl} -N-[(4,6-dimethyl-2-oxo- 1 ,2-dihydro-3- pyridinyl)methyl] -3 -methyl- 1 -( 1 -meth lethyl)- 1 H-indole-4-carboxamidea) Methyl 6-(4-fluoro-3 -form lphenyl)-3 -methyl- 1 -( 1 -methylethyl)- 1 H-indole-4-carboxylateTo a glass pressure vessel was added methyl 6-bromo-3 -methyl- 1-(1 -methylethyl)- lH-indole-4-carboxylate (500 mg, 1.612 mmol), <strong>[374538-01-9]4-fluoro-3-formylbenzeneboronic acid</strong> (375 mg, 2.233 mmol), Potassium phosphate (1.1 g, 5.18 mmol), dioxane (12 mL) and water (3 mL). The reaction was purged with N2 and charged with PdCl2(dppf)-CH2Cl2 adduct (120 mg, 0.147 mmol). The reaction was capped and stirred at 110 C for 4 hr. LCMS showed that the reaction was complete. The reaction was diluted with water, extracted with EtOAc, washed with brine, dried (MgS04), filtered, and concentrated under vacuum. Purification by silica gel chromatography (Analogix, SF25-60g, 0 to 50% EtOAc in hexanes) gave the product methyl 6-(4-fluoro-3 -formylphenyl)-3 -methyl- 1 -( 1 -methylethy 1)- 1 H-indole-4- carboxylate (560 mg, 1.585 mmol, 98% yield) as an off-white solid. 1H NMR (400MHz,DMSO-d6) delta = 10.30 (s, 1 H), 8.24 - 8.13 (m, 2 H), 8.10 (d, J= 1.5 Hz, 1 H), 7.75 (d, J= 1.8 Hz, 1 H), 7.57 - 7.46 (m, 2 H), 4.98 (quin, J= 6.6 Hz, 1 H), 3.91 (s, 3 H), 2.31 (s, 3 H), 1.46(d, J= 6.6 Hz, 6 H). MS(ES)+ m/e 354.2 [M+H]+. |
98% | With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In 1,4-dioxane; water; at 110℃; for 4h;Inert atmosphere; | To a glass pressure vessel was added methyl 6-bromo-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylate (500 mg, 1.612 mmol), <strong>[374538-01-9]4-fluoro-3-formylbenzeneboronic acid</strong> (375 mg, 2.233 mmol), Potassium phosphate (1.1 g, 5.18 mmol), dioxane (12 mL) and water (3 mL). The reaction was purged with N2 and charged with PdCl2(dppf)-CH2Cl2 adduct (120 mg, 0.147 mmol). The reaction was capped and stirred at 110 C. for 4 hr. LCMS showed that the reaction was complete. The reaction was diluted with water, extracted with EtOAc, washed with brine, dried (MgSO4), filtered, and concentrated under vacuum. Purification by silica gel chromatography (Analogix, SF25-60g, 0 to 50% EtOAc in hexanes) gave the product methyl 6-(4-fluoro-3-formylphenyl)-3-methyl-1-(1-methylethyl)-1H-indole-4-carboxylate (560 mg, 1.585 mmol, 98% yield) as an off-white solid. 1H NMR (400 MHz, DMSO-d6) delta=10.30 (s, 1H), 8.24-8.13 (m, 2H), 8.10 (d, J=1.5 Hz, 1H), 7.75 (d, J=1.8 Hz, 1H), 7.57-7.46 (m, 2H), 4.98 (quin, J=6.6 Hz, 1H), 3.91 (s, 3H), 2.31 (s, 3H), 1.46 (d, J=6.6 Hz, 6H). MS(ES)+ m/e 354.2 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | In acetonitrile; at 130℃; under 12929.0 Torr; for 0.0833333h;Microwave irradiation; | General procedure: The boronic acid (1 mmol) was added to a 10mL microwave vial equipped with a magnetic stirrer, and then acetonitrile (1 mL) was added, followed by methyliminodiacetic acid (MIDA) (147 mg, 1 mmol). The Teflon cap was added and the reaction mixture was heated using the dynamic heating method, with the maximum power set to 300W, max pressure 250 psi, max temperature 130 C, high stirring throughout and power max turned off. This method was used to hold the reaction mixture at 130 C for 5 min. After cooling, the magnetic stirrer was retrieved and the acetonitrile was removed under reduced pressure giving a crude white powder. This crude material was first triturated via sonication with deionised water (5 mL), cooled in an ice bath and collected by filtration and washed with coldwater (5 mL). This solid was then further triturated with diethyl ether (5 mL), cooled in an ice bath, collected by filtration and washed with diethyl ether (5 mL) giving pure product as a white precipitate (if not otherwise quoted), which was air dried. Notes: The 3.5 mmol scale reaction was done using a 35 mL microwave vial, with the same heating profile. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 80℃;Inert atmosphere; | General procedure: Compounds II (200-1000 mg) were mixed with the selected boronic acid (1.2 eq), fine powdered K2CO3 (3 eq), Pd(PPh3)4 (0.01 eq) and 1,4-dioxane/water (1/1 by vol.%, 4-8 mL). The reaction was then stirred at 80 C for 2-5 h under nitrogen atmosphere.The solvent was removed and the product was diluted with water(25-50 mL) and extracted with Et2O or EtOAc (25-100 mL), the water phase was extracted with more diethyl ether or EtOAc (2 x 25 mL). The combined organic phases were washed with saturated aq NaCl solution (25 mL), dried over anhydrous Na2SO4,filtered and concentrated in vacuo. Purification was performed as specified for each individual compound. 4.7.15 (R)-2-Fluoro-5-(4-((1-phenylethyl)amino)thieno[2,3-d]pyrimidin-6-yl)benzaldehyde (16b) fx25 Compound 16b was prepared as described in Section 4.7 , starting with IIb·HCl (400 mg, 1.079 mmol) and <strong>[374538-01-9](4-fluoro-3-formylphenyl)boronic acid</strong> (217 mg, 1.295 mmol). The crude product was purified by silica-gel column chromatography (Et2O/n-pentane, 6/4), Rf = 0.18. This gave 293 mg (0.777 mmol, 72%) of 16b as an orange solid, mp 143-145 C; HPLC purity: 97%, tR = 26.4 min; [alpha]D20 = -360.9 (c 1.00, DMSO); 1H NMR (400 MHz, DMSO-d6) delta: 10.29 (s, 1H), 8.32-8.27 (m, 3H), 8.14-8.10 (m, 1H), 8.02-7.97 (m, 1H), 7.59-7.53 (m, 1H), 7.46-7.41 (m, 2H), 7.36-7.30 (m, 2H), 7.25-7.20 (m, 1H), 5.56-5.47 (m, 1H), 1.57 (d, J = 7.0, 3H); 13C NMR (100 MHz, DMSO-d6) delta: 187.5 (d, J = 5.0), 165.4, 163.1 (d, J = 259.3), 155.9, 154.2, 144.5, 135.5, 133.4 (d, J = 9.4), 130.3 (d, J = 3.6), 128.3 (2C), 126.7, 126.0 (2C), 125.3 (d, J = 2.1), 124.3 (d, J = 9.5), 118.1 (d, J = 21.3), 117.4, 116.8, 49.1, 22.5; 19F NMR (564 MHz, DMSO-d6, C6F6) delta: -123.54 (s, dec.); IR (neat, cm-1): 3440, 3382, 2925, 1701, 1580, 1517, 1486, 1353, 1303, 775, 762, 699; HRMS (APCI/ASAP, m/z): 378.1071 (calcd. C21H17FN3OS, 378.1076, [M+H]+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; at 20 - 90℃;Inert atmosphere; Sealed tube; | General procedure: To a flame-dried thick-walled vial was added theheteroaryl halide or aryl halide (1.0 equiv), Pd2(dba)3 (0.05 equiv),tri-tert-butylphosphonium tetrafluoroborate (0.12 equiv), cesiumcarbonate (2.0 equiv) and the boronic acid or ester (1.3 equiv).The vial was sealed with a septum and then the vessel was purgedwith argon for several minutes. Next, dioxane (0.2 M, degassed bybubbling either nitrogen or argon) was added. Under a blanket ofargon, the septum was replaced with a Teflon-coated screw cap.The reaction was stirred at rt for 1 h and then the reaction waswarmed to 90 C for 12-24 h as determined by HPLC analysis ofthe reaction mixture. The crude product was either used withoutfurther purification or it was purified by either column chromatographyon silica gel or by reverse phase chromatography |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With potassium carbonate; In 1,4-dioxane; water; at 100℃; for 1h;Inert atmosphere; | General procedure: The 6-iodopyrrolopyrimidine (6a - 6c, 7a - 7b or 7d) (50-350mg) was mixed with the selected arylboronic acid (1.2 eq), fine powdered K2CO3 (3 eq), XPhos (5mol %)/2nd generation XPhos precatalyst (5mol %) system or PdCl2(dppf) (5mol %) and mixture with degassed 1,4-dioxane/H2O (1/1 by vol. %, 2-8mL). The reaction was then stirred at 100C for 0.5-10h under N2 atmosphere. The solvent was removed and the product was diluted with H2O (25-100mL) and extracted with EtOAc (50-120mL), several times if required. The combined organic phases were washed with saturated aq. NaCl solution (30mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo. Purification was performed as described for each individual compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56% | With potassium carbonate; XPhos; In 1,4-dioxane; water; at 100℃; for 0.133333h;Inert atmosphere; | General procedure: To a mixture of the selected arylboronic acid (0.610mmol, 1.2 equiv.), K2CO3 (1.53mmol, 3 equiv.), XPhos (0.0250mmol, 0.05 equiv.), 2nd generation XPhos pre-catalyst (0.0250mmol, 0.05 equiv.), and the selected 4-amino-5-iodo-7H-pyrrolo [2,3-d]pyrimidine (0.511mmol, 1 equiv.) in 1,4-dioxane (3mL) was added water (3mL) under a nitrogen atmosphere. The reaction mixture was stirred at 100C until complete conversion. The solvent was removed before water (15mL) and EtOAc (25mL) were added, the phases were separated and the water phase was extracted with more EtOAc (3×20mL). The combined organic phases were washed with brine (20mL), dried over Na2SO4, filtered and concentrated. Purification was as stated for each individual compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With potassium carbonate; XPhos; In 1,4-dioxane; water; at 100℃; for 2h;Inert atmosphere; | General procedure: To a mixture of the selected arylboronic acid (0.610mmol, 1.2 equiv.), K2CO3 (1.53mmol, 3 equiv.), XPhos (0.0250mmol, 0.05 equiv.), 2nd generation XPhos pre-catalyst (0.0250mmol, 0.05 equiv.), and the selected 4-amino-5-iodo-7H-pyrrolo [2,3-d]pyrimidine (0.511mmol, 1 equiv.) in 1,4-dioxane (3mL) was added water (3mL) under a nitrogen atmosphere. The reaction mixture was stirred at 100C until complete conversion. The solvent was removed before water (15mL) and EtOAc (25mL) were added, the phases were separated and the water phase was extracted with more EtOAc (3×20mL). The combined organic phases were washed with brine (20mL), dried over Na2SO4, filtered and concentrated. Purification was as stated for each individual compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With chloro(2-dicyclohexylphosphino-2?,4?,6?-triisopropyl-1,1?-biphenyl)[2-(2?-amino-1,1?-biphenyl?)]palladium(II); potassium carbonate; XPhos; In 1,4-dioxane; water; at 100℃; for 0.25h;Inert atmosphere; | General procedure: Compound 14 [15] (93 mg, 0.280 mmol), <strong>[374538-01-9](4-fluoro-3-formylphenyl)boronic acid</strong> (55 mg, 0.328 mmol), K2CO3 (128 mg, 0.926 mmol),XPhos (4 mg, 0.008 mmol) and XPhos Pd G2 (5 mg, 0.006 mmol) weredissolved in 1,4-dioxane (1 mL) and water (1 mL) under a nitrogen atmosphere.The reaction mixture was stirred at 100 C for 15 min beforewater (10 mL) was added and the aqueous phase was extracted withEtOAc (3×10 mL). The combined organic phases were washed withbrine (10 mL), dried over anhydrous Na2SO4, filtered and concentratedin vacuo. The crude aldehyde product was dissolved in THF (10 mL)and MeOH (5 mL) before NaBH4 (34.8 mg, 0.920 mmol) was added. Themixture was stirred for 2 h at room temperature before water (20 mL)was added. The water phase was extracted with EtOAc (3×20 mL) andthe combined organic phases were washed with brine (20 mL), driedover anhydrous Na2SO4, filtered and concentrated in vacuo. Silica-gelcolumn chromatography (CH2Cl2/MeOH/NH3 (25% aq. solution), 80/10/1, Rf=0.17) gave the product 15l as a beige powder, 76 mg(0.231 mmol, 81%), mp. 99-100 C; HPLC purity > 99%, tR=6.9 min;1H NMR (600 MHz, DMSO-d6): 8.15 (s, 1H), 7.55-7.53 (m, 1H),7.36-7.33 (m, 2H), 7.26-7.24 (m, 1H), 6.07 (br s, 2H), 5.32 (t,J=5.6 Hz, 1H), 4.61-4.60 (m, 2H), 4.28 (t, J=6.5 Hz, 2H), 2.74-2.72(m, 2H), 2.23 (s, 6H); 13C NMR (150 MHz, DMSO-d6): 158.6 (d,J=244.3 Hz), 157.2, 151.5, 150.3, 130.9 (d, J=3.3 Hz), 129.6 (d,J=15.3 Hz), 128.8 (d, J=5.5 Hz), 128.4 (d, J=7.6 Hz), 123.6, 115.4(d, J=22.0 Hz), 114.2, 99.7, 58.2, 56.7 (d, J=4.4 Hz), 44.9 (2C),41.3; 19F NMR (376 MHz, DMSO-d6, C6F6): -125.5 (s, dec.); IR (neat,cm-1): 3081 (w, br), 1636 (m), 1595 (s), 1481 (m), 1314 (m), 1205(m), 1049 (m), 1013 (m), 779 (s), 623 (m); HRMS (APCI/ASAP+, m/z):found 330.1728 (calcd. C17H21N5OF, 330.1730 [M+H]+). |
Tags: 374538-01-9 synthesis path| 374538-01-9 SDS| 374538-01-9 COA| 374538-01-9 purity| 374538-01-9 application| 374538-01-9 NMR| 374538-01-9 COA| 374538-01-9 structure
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P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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