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Chemical Structure| 37579-29-6 Chemical Structure| 37579-29-6

Structure of 37579-29-6

Chemical Structure| 37579-29-6

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Product Details of [ 37579-29-6 ]

CAS No. :37579-29-6
Formula : C2Cl2N2O
M.W : 138.94
SMILES Code : ClC1=NC(Cl)=NO1
MDL No. :MFCD08236812
Boiling Point : No data available

Safety of [ 37579-29-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 37579-29-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 37579-29-6 ]

[ 37579-29-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 37579-29-6 ]
  • [ 38240-29-8 ]
  • 3-chloro-5-(3-nitro-pyridin-2-ylthio)-1,2,4-oxadiazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In water; acetonitrile; STR60 7.0 g (0.05 mol) of 3,5-dichloro-1,2,4-oxadiazole in 25 ml of anhydrous acetonitrile are added dropwise to 7.8 g (0.05 mol) of <strong>[38240-29-8]3-nitro-2-mercaptopyridine</strong> (compare Int. J. Pept. Prot. Res. 16, 392 (180)) and 6.9 g (0.05 mol) of potassium carbonate in 100 ml of anhydrous acetonitrile at room temperature, with stirring. When the addition has ended, the mixture is heated to the reflux temperature for 1 hour, and after cooling, 300 ml of water are added, the mixture is extracted three times with 200 ml of methylene chloride each time and the combined organic phases are washed with 200 ml of water, dried over sodium sulphate and concentrated in vacuo. The residue crystallizes from diisopropyl ether. 10.2 g (79% of theory) of 3-chloro-5-(3-nitro-2-pyridylthio)-1,2,4-oxadiazole of melting point 84 C. are obtained. The following 3-chloro-1,2,4-oxadiazoles of the general formula (I) are obtained in a corresponding manner and in accordance with the general statements on the preparation:
 

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