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[ CAS No. 376584-30-4 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 376584-30-4
Chemical Structure| 376584-30-4
Structure of 376584-30-4 *Storage: {[proInfo.prStorage]}

Quality Control of [ 376584-30-4 ]

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Alternatived Products of [ 376584-30-4 ]

Product Details of [ 376584-30-4 ]

CAS No. :376584-30-4MDL No. :MFCD11044671
Formula : C15H20BNO3 Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :273.14Pubchem ID :-
Synonyms :

Computed Properties of [ 376584-30-4 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 376584-30-4 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P280-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 376584-30-4 ]

  • Downstream synthetic route of [ 376584-30-4 ]

[ 376584-30-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 381233-96-1 ]
  • [ 376584-30-4 ]
  • [ 1396776-45-6 ]
YieldReaction ConditionsOperation in experiment
79% With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In N,N-dimethyl-formamide; at 50℃;Inert atmosphere; To a stirred mixture of 6-(4,4,5,5-tetramethyl- 1 ,3,2-dioxaborolan-2-yl)-3 ,4- dihydroisoquinolin- 1 (2H)-one (2-2) (400.0 mg, 1.46 mmol), 5-bromo-3 -iodopyridin-2-amine (2-3, 438.1 mg, 1.46 mmol) and K2C03 (653.3 mg, 5.84 mmol) in DMF (8 mL) under an atmosphere of argon was added Pd(PPh3)2C12 (102.5 mg, 0.14 mol). The resulting mixture was heated at 50 C overnight, then cooled to r.t and diluted with saturated NaHCO3 solution (20 mL). The mixture was then extracted with ethyl acetate (4 xx 30 mL). The combined ethyl acetate extracts were washed with brine (5 x 20 mL), dried with MgSO4, filtered and concentrated in vacuo. The resulting residue was purified by flash column chromatography (DCM/MeOH= 100/3) to provide intermediate 2-4 (yellow solid, 0.37 g, 79% yield).
53% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; water; at 70℃; for 64h;Inert atmosphere; Under N atmosphere, a mixture of 2 (3.4 g, 12.45 mmol), 5-bromo-3 iodopyridin-2-amine (4.5 g, 14.95 mmol), sodium carbonate (2.64 g, 24.9 mmol) and Pd(PPh3)4 (1.44 g, 1 25 mmol) in dioxane (80 ml.) and water (10 mL) was heated at 70C for 64 hours. 'The mixture was concentrated and the residue was purified by flash column chromatography (0% to 25% MeOH in DCM) to afford 2.1 g product in 53% yield. LCMS (ESI) m/z 318.18 | { M 1 1 ) ; calcd f
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