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Chemical Structure| 37734-89-7 Chemical Structure| 37734-89-7

Structure of 37734-89-7

Chemical Structure| 37734-89-7

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Product Details of [ 37734-89-7 ]

CAS No. :37734-89-7
Formula : C16H14N2
M.W : 234.30
SMILES Code : C1(C2=CC=CC=C2)=NC=CN1CC3=CC=CC=C3
MDL No. :MFCD06660149

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Application In Synthesis of [ 37734-89-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 37734-89-7 ]

[ 37734-89-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 38696-20-7 ]
  • [ 37734-89-7 ]
  • [ 1217902-36-7 ]
YieldReaction ConditionsOperation in experiment
30% With potassium carbonate;trifuran-2-yl-phosphane; palladium diacetate; In N,N-dimethyl-formamide; at 140℃; for 16h;Inert atmosphere; To a mixture consisting of <strong>[38696-20-7]5-bromo-2-phenylpyrimidine</strong> (1.2 g, 5.1 mmol), palladium (II) acetate (Strem, 0.048 g, 0.21 mmol), tris(2-furyl)phosphine (TCI America, 0.098 g, 0.43 mmol) and potassium carbonate (1.17 g, 8.52 mmol) was added a solution consisting of 1-benzyl-2-phenyl-1H-imidazole (1.0 g, 4.3 mmol) in N,N-dimethylformamide (10 mL). The reaction mixture was brought to reflux at 140° C. (degrees Celsius) while under a N2 atmosphere. After stirring for 16 hours at reflux the solution was cooled to room temperature. The reaction mixture was partitioned between ethyl acetate (250 mL) and saturated aqueous ammonium chloride (100 mL). The phases were separated and the organic layer was washed with brine (150 mL), and was subsequently dried over anhydrous magnesium sulfate. Concentration under reduced pressure affords the crude product as an orange oil (0.658 g). The product was purified by flash silica column chromatography. Elution through a 80-g Silicycle.(R). flash silica cartridge with gradient of 5percent to 30percent ethyl acetate in hexanes afforded the title intermediate (0.495 g, 30percent yield); Rf 0.38 with 1:1 v/v ethyl acetate-hexane; 1H-NMR (400 MHz; CDCl3) delta 8.7 (s, 2H), 8.4 (m, 2H), 7.6 (m, 2H), 7.5-7.25 (m, 10H), 6.9 (m, 2H), 5.32 (s, 2H); MS (ESI+) m/z 389.2 (M+1); H-PGDS FPBA IC50: 15 muM.
 

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