Alternatived Products of [ 379-57-7 ]
Product Details of [ 379-57-7 ]
CAS No. : | 379-57-7 |
MDL No. : | MFCD00191587 |
Formula : |
C19H13F3O
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | JALVMPWRAMMHQY-UHFFFAOYSA-N |
M.W : |
314.30
|
Pubchem ID : | 2778005 |
Synonyms : |
|
Application In Synthesis of [ 379-57-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 379-57-7 ]
- 1
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[ 345-92-6 ]
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[ 352-13-6 ]
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[ 379-57-7 ]
Yield | Reaction Conditions | Operation in experiment |
81% |
Stage #1: 4-flourophenylmagnesium bromide With magnesium; ethylene dibromide In tetrahydrofuran at 36 - 60℃; Schlenk technique; Inert atmosphere;
Stage #2: 4,4'-Difluorobenzophenone In tetrahydrofuran at 0 - 25℃; Schlenk technique; Inert atmosphere; |
|
45% |
In tetrahydrofuran for 2h; Heating; |
|
|
Stage #1: 4,4'-Difluorobenzophenone; 4-flourophenylmagnesium bromide In various solvent(s) for 3h; Heating;
Stage #2: With hydrogenchloride Further stages.; |
|
Reference:
[1]Lutz, Marius D.R.; Gasser, Valentina C.M.; Morandi, Bill
[Chem, 2021, vol. 7, # 4, p. 1108 - 1119]
[2]Dhar; Borden; Tyagarajan; Smith; Branchek; Weinshank; Gluchowski
[Journal of Medicinal Chemistry, 1994, vol. 37, # 15, p. 2334 - 2342]
[3]McNaughton-Smith, Grant A.; Burns, J. Ford; Stocker, Jonathan W.; Rigdon, Gregory C.; Creech, Christopher; Arlington, Susan; Shelton, Tara; De Franceschi, Lucia
[Journal of Medicinal Chemistry, 2008, vol. 51, # 4, p. 976 - 982]