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Chemical Structure| 380893-61-8 Chemical Structure| 380893-61-8

Structure of 380893-61-8

Chemical Structure| 380893-61-8

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Product Details of [ 380893-61-8 ]

CAS No. :380893-61-8
Formula : C7H8BrNO3S
M.W : 266.11
SMILES Code : O=S(OCC1=NC=C(Br)C=C1)(C)=O

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Application In Synthesis of [ 380893-61-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 380893-61-8 ]

[ 380893-61-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 380893-61-8 ]
  • [ 71083-06-2 ]
  • [ 1193116-77-6 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 60℃; for 15h;Inert atmosphere; To a solution of ethyl-8-fluoro-4-oxo-l,4-dihydroquinoline-3-carboxylate (5.00 g,21.3 mmol) in 50 mL of DMF under nitrogen was added the above compound (8.48 g, 31.9 mmol), potassium iodide (0.176 g, 1.06 mmol), and potassium carbonate (3.53 g, 25.5 mmol). The reaction mixture was stirred at 6O0C for 15 hours, cooled to room temperature, and diluted with 200 mL of water. The resulting solid was washed with water (2 x 100 mLl) and diethyl0 ether (2 x 75 mL) and dried in vacuo to provide ethyl l-[(5-bromopyridin-2-yl)methyl]-8-fluoro- 4-oxo- l,4-dihydroquinoline-3-carboxylate that gave a proton NMR spectra consistent with theory and a mass ion (ES+) of 407.0 for M+H+(81Br).
 

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