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Chemical Structure| 383869-57-6 Chemical Structure| 383869-57-6

Structure of 383869-57-6

Chemical Structure| 383869-57-6

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Product Details of [ 383869-57-6 ]

CAS No. :383869-57-6
Formula : C9H10BrNO3
M.W : 260.09
SMILES Code : O=[N+]([O-])C1=CC(Br)=CC=C1OC(C)C
MDL No. :MFCD14652100

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Application In Synthesis of [ 383869-57-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 383869-57-6 ]

[ 383869-57-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 383869-57-6 ]
  • [ 1019442-22-8 ]
YieldReaction ConditionsOperation in experiment
64% With hydrogenchloride; tin(ll) chloride; In tetrahydrofuran; water; at 50.0℃; for 24.0h; General procedure: To a solution of 4-bromo-1 -isopropoxy-2-nitrobenzene (prepared using general procedure 1 , 84%, 17.54 g, 67.4 mmol) in THF (270 mL), HCI (1 M aq, 270 mL, 270 mmol, 4.0 eq) and stannous chloride (38 g, 282 mmol, 3.0 eq) were added and heated to 50C for 24 hours. Upon completion, the mixture was quenched with saturated aqueous sodium bicarbonate, filtered over celite, and the crude product was extracted twice with ethyl acetate. The combined organic layers were dried (Na2S04), concentrated, and purified by combiflash 0 to 30% EtOAc to yield bromo-isopropoxy amine (9.93 g, 64% yield) 1 H NMR (400 MHz, CDCI3): delta 6.82 p.p.m. (d, J=2.4 Hz, 1 H), 6.77 (dd, J1=8.5 Hz, J2=2.4 Hz, 1 H), 6.63 (d, J=8.6 Hz, 1 H), 4.46 (hept, J=1 .5 Hz, 1 H), 1 .33 (d, J=6.0, 6H), 13C NMR (125 MHz): delta 1 14.4, 138.9, 120.6, 1 17.6, 1 14.8, 1 13.2, 71 .0 HRMS (m/z): [M+] calculated for C9H13NOBr 230.1 , found 229.01
 

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