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Chemical Structure| 38533-38-9 Chemical Structure| 38533-38-9

Structure of 38533-38-9

Chemical Structure| 38533-38-9

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Product Details of [ 38533-38-9 ]

CAS No. :38533-38-9
Formula : C6H11NO2
M.W : 129.16
SMILES Code : O=C([C@H]1N[C@@H](C)CC1)O
MDL No. :MFCD19217648

Safety of [ 38533-38-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 38533-38-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 38533-38-9 ]

[ 38533-38-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 38533-38-9 ]
  • [ 334769-80-1 ]
YieldReaction ConditionsOperation in experiment
2.14 g With sodium hydroxide; In water; acetonitrile; at 20℃; for 1h; General procedure: Trifluoroacetic acid (10ml) was added to a solution of compound4a(4.7g, 0.014mol) in dichloromethane (30ml). The reaction mixture was stirred for 3h at room temperature. The solvent was removed in vacuo, and the residue was azeotroped with toluene to afford the crude product. To a solution of the product in methanol (50ml) was added 10percent Pd/C (500mg, 50percent wetted, type AD). The resulting mixture was stirred under a hydrogen atmosphere (1atm) for 16h at room temperature. The mixture was filtered to remove the catalyst, and the filtrate was concentrated in vacuo to afford the crude product. To a solution of the product in acetonitrile (60ml) with water (10ml) was added di-tert-butyl dicarbonate (4.58g, 21mmol) and 1N aqueous sodium hydroxide solution (35ml, 35mmol). The resulting solution was stirred for 1h at room temperature. After removing the solvent in vacuo, the residue was diluted with chloroform, and extracted with water. The aqueous layer was diluted with saturated aqueous NH4Cl, and the solvent was removed in vacuo. The residue was diluted with 10percent MeOH/CHCl3solution, and dried over magnesium sulfate. The mixture was filtered, and the solvent was removed in vacuo to afford the crude product. Purification by flash silica gel chromatography with CHCl3/MeOH (15:1, v/v) provided the title compound (2.14g, 67percent yield from4a);1H NMR (400MHz, CDCl3)delta: 1.25 (3H, d,J=6.3Hz), 1.48 (9H, s), 1.63?1.68 (1H, m), 2.00?2.09 (2H, m), 2.26?2.33 (1H, m), 3.91?3.97 (1H, m), 4.30?4.34 (1H, m); ESI/MS:m/z=252 (M+Na).
 

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