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CAS No. : | 38583-51-6 | MDL No. : | MFCD02182966 |
Formula : | C5H7N3OS2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 189.26 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | Stage #1: at 6℃; for 2.33333 h; Stage #2: at 4℃; for 4.33333 h; |
The pharmaceutical intermediate 2-acetamido-5-chlorosulfonyl-1,3,4-thiadiazole synthesis method comprises the following steps:A: 2 mol of 2-acetamido-5-methylthio-1,3,4-thiadiazole was added to the reaction vessel., control the temperature to 6 ° C,Add 2.3L potassium nitrate solution,Control stirring speed 250 rpm, reaction 140 min;B: 3 mol of lanthanum nitrate was added in 4 portions, and the temperature was controlled at 4 ° C.6 mol of 3-chlorophenol solution was added in 4 times over 80 min, the reaction was continued for 3 h, and the pH of the solution was adjusted to 6,The solid was precipitated, washed 4 times with sodium sulfate solution and 6 times with cyclobutane solution.The methylamine solution was washed 5 times, recrystallized in a t-butanol solution, and dehydrated with anhydrous calcium sulfate.The yield of the finished 2-acetamido-5-chlorosulfonyl-1,3,4-thiadiazole was 459.8 g, 95percent. |