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[ CAS No. 38692-72-7 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 38692-72-7
Chemical Structure| 38692-72-7
Chemical Structure| 38692-72-7
Structure of 38692-72-7 * Storage: {[proInfo.prStorage]}
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Product Details of [ 38692-72-7 ]

CAS No. :38692-72-7 MDL No. :MFCD16620636
Formula : C8H7BrO3 Boiling Point : -
Linear Structure Formula :- InChI Key :SKGHTMGJWQZJEI-UHFFFAOYSA-N
M.W : 231.04 Pubchem ID :22106721
Synonyms :

Safety of [ 38692-72-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 38692-72-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 38692-72-7 ]

[ 38692-72-7 ] Synthesis Path-Downstream   1~7

  • 2
  • [ 38692-72-7 ]
  • [ 149428-97-7 ]
YieldReaction ConditionsOperation in experiment
38% With potassium tert-butylate; In DMF (N,N-dimethyl-formamide); at 20℃; for 3.25h; Eine Lsung von 12.4 g (0.053 Mol) 2-Hydroxy-5-brom-phenylessigsure in 125 ml Dimethylformamid wird mit 14 g (0.125 Mol) Kalium-tert.butylat versetzt. Nach 15 Minuten bei Raumtemperatur werden 18.5 g (0.108 Mol) Benzylbromid zugegeben. Die Reaktionslsung wird 3 Stunden bei Raumtemperatur gerhrt, auf Eiswasser gegossen und mit Essigester extrahiert. Die vereinten organischen Extrakte werden getrocknet und eingedampft. Der Rckstand wird in 100 ml Ethanol gelst und nach Zusatz von 50 ml 2N Natronlauge 3 Stunden bei Raumtemperatur gerhrt. Das Solvens wird abdestilliert, der Rckstand wird mit 2N Salzsure auf pH 4 gestellt. Nach Extraktion mit Essigester werden die organischen Phasen getrocknet und eingedampft. Der Rckstand wird an Kieselgel chromatographiert und mit Petrolether/Essigester (8:2) eluiert. Ausbeute: 6.7 g (38 % der Theorie), Rf-Wert: 0.50 (Kieselgel; Essigester/Petrolether = 1:1)
  • 3
  • [ 38692-72-7 ]
  • [ 198277-06-4 ]
YieldReaction ConditionsOperation in experiment
126.0 g (94%) With hydrogenchloride; sodium hydroxide; In tetrahydrofuran; water; A. 4-Bromo-2-(2-hydroxy-ethyl)-phenol (10a): A solution of borane-methyl sulfide complex (371 mL, 0.742 mol, 2M in THF) was added dropwise over about 1.5 hours to a solution of 143.0 g (0.619 mol) of <strong>[38692-72-7]5-bromo-2-hydroxyphenylacetic acid</strong> in 1400 mL of dry THF, keeping the reaction temperature below about 30 C. The reaction mixture was stirred overnight at room temperature. Then, it was cooled to about 0 C., and 5M NaOH (706 mL) was added slowly with stirring, keeping the temperature below about 10 C. The reaction mixture was then was stirred in an ice bath for about 0.5 hour and at room temperature for about 2 hours. The THF was evaporated and the oily residue was diluted with 300 mL of water. A cold solution of 3M HCl was added slowly to pH 7, and the mixture was extracted three times with 300 mL of ethyl acetate. The combined organic layers were washed with water, brine, dried (Na2 SO4) and concentrated to a light yellow oil. This was triturated in 300 mL hexanes and filtered to give 126.0 g (94%) of 10a as a tan solid, mp 63-65 C. 1 H NMR (CDCl3): d=9.50 (s, 1 H); 7.16 (s, 1 H); 7.06 (d, 1H); 6.66 (d, 1 H); 4.63 (br, 1 H); 3.55 (t, 2 H); 2.62 (t, 2 H). MS (El): m/z=218 (M+1).
  • 5
  • [ 38692-72-7 ]
  • 5-bromo-3-(4-methylbenzyl)-3-(3,4,5-trifluorophenyl)benzofuran-2(3H)-one [ No CAS ]
  • 6
  • [ 38692-72-7 ]
  • methyl 2-(5-bromo-2-((4-methylbenzyl)oxy)phenyl)acetate [ No CAS ]
  • 7
  • [ 38692-72-7 ]
  • methyl 2-(5-bromo-2-((4-methylbenzyl)oxy)phenyl)-2-diazoacetate [ No CAS ]
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