Home Cart 0 Sign in  

[ CAS No. 38696-23-0 ]

{[proInfo.proName]}
Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 38696-23-0
Chemical Structure| 38696-23-0
Structure of 38696-23-0 *Storage: {[proInfo.prStorage]}

Quality Control of [ 38696-23-0 ]

Related Doc. of [ 38696-23-0 ]

SDS

Product Details of [ 38696-23-0 ]

CAS No. :38696-23-0MDL No. :MFCD18410559
Formula : C6H7BrN2O Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :203.04Pubchem ID :51401365
Synonyms :

Computed Properties of [ 38696-23-0 ]

TPSA : 35 H-Bond Acceptor Count : 3
XLogP3 : 1.6 H-Bond Donor Count : 0
SP3 : 0.33 Rotatable Bond Count : 1

Safety of [ 38696-23-0 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P280-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 38696-23-0 ]

  • Downstream synthetic route of [ 38696-23-0 ]

[ 38696-23-0 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 73183-34-3 ]
  • [ 38696-23-0 ]
  • 2-methoxy-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 105℃; for 2h;Inert atmosphere; To a solution of 5-bromo-2-methoxy -4-methyl-pyrimidine (500 mg, 2.46 mmol, 1.00 equiv), 4, 4, 5, 5-tetramethyl-2-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)-l, 3, 2- dioxaborolane (813 mg, 3.20 mmol, 1.30 equiv) and potassium acetate (483 mg, 4.93 mmol, 2.00 equiv) in dioxane (5.00 mL) was added Pd(dppf)Cl2 (180 mg, 246 pmol, 0.10 equiv) under nitrogen. The resultant mixture was stirred at 105 C for 2 h. The mixture was concentrated in vacuo to give the crude material, which was purified by column chromatography (petroleum ether/ethyl acetate, 1/0 to 1 : 1) to afford 2-methoxy-4-methyl-5-(4, 4, 5, 5-tetramethyl-l, 3, 2- dioxaborolan-2-yl)pyrimidine (150 mg, 539 pmol, 21.9% yield, 90.0% purity) as a red oil. 1H NMR (400MHz, MeOD) d = 8.69 (s, 1H), 4.03 (s, 3H), 2.65 (s, 3H), 1.38 (s, 12H).
Historical Records

Related Functional Groups of
[ 38696-23-0 ]

Bromides

Chemical Structure| 14001-66-2

[ 14001-66-2 ]

5-Bromo-2-methoxypyrimidine

Similarity: 0.86

Chemical Structure| 17758-11-1

[ 17758-11-1 ]

5-Bromo-2-ethoxypyrimidine

Similarity: 0.80

Chemical Structure| 1439-09-4

[ 1439-09-4 ]

5-Bromo-4-methylpyrimidine

Similarity: 0.74

Chemical Structure| 56686-16-9

[ 56686-16-9 ]

5-Bromo-2,4-dimethoxypyrimidine

Similarity: 0.72

Chemical Structure| 148214-56-6

[ 148214-56-6 ]

5-Bromo-2-methoxypyrimidin-4-amine

Similarity: 0.72

Ethers

Chemical Structure| 14001-66-2

[ 14001-66-2 ]

5-Bromo-2-methoxypyrimidine

Similarity: 0.86

Chemical Structure| 17758-11-1

[ 17758-11-1 ]

5-Bromo-2-ethoxypyrimidine

Similarity: 0.80

Chemical Structure| 14001-60-6

[ 14001-60-6 ]

2-Methoxy-4-methylpyrimidine

Similarity: 0.79

Chemical Structure| 944901-04-6

[ 944901-04-6 ]

(2-Methoxypyrimidin-4-yl)methanamine

Similarity: 0.73

Chemical Structure| 56686-16-9

[ 56686-16-9 ]

5-Bromo-2,4-dimethoxypyrimidine

Similarity: 0.72

Related Parent Nucleus of
[ 38696-23-0 ]

Pyrimidines

Chemical Structure| 14001-66-2

[ 14001-66-2 ]

5-Bromo-2-methoxypyrimidine

Similarity: 0.86

Chemical Structure| 17758-11-1

[ 17758-11-1 ]

5-Bromo-2-ethoxypyrimidine

Similarity: 0.80

Chemical Structure| 14001-60-6

[ 14001-60-6 ]

2-Methoxy-4-methylpyrimidine

Similarity: 0.79

Chemical Structure| 1439-09-4

[ 1439-09-4 ]

5-Bromo-4-methylpyrimidine

Similarity: 0.74

Chemical Structure| 944901-04-6

[ 944901-04-6 ]

(2-Methoxypyrimidin-4-yl)methanamine

Similarity: 0.73