388109-26-0|Ethyl 3-oxotetrahydro-2H-pyran-4-carboxylate| Ambeed

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Quality Control of [ 388109-26-0 ] Purity: 98% SDS Specification

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Product Details of [ 388109-26-0 ]

CAS No. :	388109-26-0
Formula :	C₈H₁₂O₄
M.W :	172.18
SMILES Code :	O=C(C1C(COCC1)=O)OCC
MDL No. :	MFCD19440853
InChI Key :	APAWJCZGOJKZPB-UHFFFAOYSA-N
Pubchem ID :	21362493

Safety of [ 388109-26-0 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 388109-26-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 388109-26-0 ]

[ 388109-26-0 ] Synthesis Path-Downstream 1~35

1
[ 388109-26-0 ]
[ 3886-69-9 ]
ethyl 5-(((1R)-1-phenylethyl)amino)-3,6-dihydro-2H-pyran-4-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With p-toluenesulfonic acid monohydrate; In benzene;	Part D. Preparation of (R)-5-(1-Phenyl-ethylamino)-3,6-dihydro-2H-pyran-4-carboxylic acid ethyl ester A solution of <strong>[388109-26-0]3-oxo-tetrahydro-pyran-4-carboxylic acid ethyl ester</strong> (3.03 g, 17.6 mmol), R-(+)-alpha-methylbenzylamine (2.35 g, 19.4 mmol) and p-toluenesulfonic acid hydrate (67 mg, 230 mumol) in benzene (60 mL) was heated at reflux under a Dean-Stark trap for 16 h. The cooled mixture was concentrated in vacuo to provide the product as a yellow oily semisolid (5.05 g), used without further purification. 1H NMR (300 mHz, CDCl3) delta 8.97 (bd, J=7.3 Hz, 1H), 7.3-7.2 (m, 5H), 4.41 (m, 1H), 4.30 (d, J=16.1 Hz, 1H), 4.18 (q, J=7.3 Hz, 2H), 3.91 (d, J=16.1 Hz, 1H), 3.64 (m, 2H), 2.34 (m, 2H), 1.48 (d, J 6.5 Hz, 3H), 1.30 (t, J 7.3 Hz, 3H).

References: [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 2992 - 2997.
[2]Patent: US2003/32654,2003,A1 .

2
[ 388109-26-0 ]
[ 388109-32-8 ]