Alternatived Products of [ 3894-09-5 ]
Product Details of [ 3894-09-5 ]
CAS No. : | 3894-09-5 |
MDL No. : | MFCD00001477 |
Formula : |
C14H18O2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | AAJLPPDFIRPBDA-UHFFFAOYSA-N |
M.W : |
218.29
|
Pubchem ID : | 97942 |
Synonyms : |
|
Application In Synthesis of [ 3894-09-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 3894-09-5 ]
- 1
-
[ 103-82-2 ]
-
[ 953-91-3 ]
-
[ 3894-09-5 ]
Yield | Reaction Conditions | Operation in experiment |
94% |
Stage #1: phenylacetic acid With lithium diethylamide In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: cyclohexyl tosylate In tetrahydrofuran at 20℃; for 4h; |
|
|
With n-butyllithium In tetrahydrofuran at -70 - -20℃; |
|
Reference:
[1]Brun, Eva M.; Gil, Salvador; Mestres, Ramón; Parra, Margarita
[Synthesis, 2000, # 8, p. 1160 - 1165]
[2]Denonne, Frederic; Binet, Sophie; Burton, Maggi; Collart, Philippe; Defays, Sabine; Dipesa, Alan; Eckert, Maria; Giannaras, Alexander; Kumar, Seema; Levine, Beth; Nicolas, Jean-Marie; Pasau, Patrick; Pegurier, Cecile; Preda, Dorin; Van houtvin, Nathalie; Volosov, Andrew; Zou, Dong
[Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 12, p. 3262 - 3265]
- 2
-
[ 3894-09-5 ]
-
[ 26487-67-2 ]
-
2-(hexahydro-1H-azepin-1-yl)ethyl cyclohexylphenylethanoate
[ No CAS ]
- 3
-
[ 3894-09-5 ]
-
[ 27841-33-4 ]
-
N-(2-amino-4,5-dimethoxyphenyl)-2-cyclohexyl-2-phenylacetamide
[ No CAS ]
- 4
-
[ 4335-77-7 ]
-
[ 3894-09-5 ]
- 5
-
[ 544-13-8 ]
-
[ 3894-09-5 ]
-
[ 1121-89-7 ]
-
[ 3893-23-0 ]
Yield | Reaction Conditions | Operation in experiment |
92% |
With aluminum (III) chloride at 200℃; for 2.5h; Sealed tube; |
Thermal-Catalyzed Reaction of Acids 1 with Glutaronitrile; General Procedure 1 (GP1)
General procedure: In a glass tube, the glutaronitrile (282 mg, 3.0 mmol, 1.0 equiv) was added to a mixture ofthe respective acid 1(3.0 mmol) and AlCl3(8mg, 0.06 mmol, 0.02 equiv). The tubewas then sealed (with a screwcap) and the mixture was allowed to stir at 200 °C for 5 h. After completion of the reaction, the crude mixture was diluted with EtOH (10 mL), silica gel (3 g) was then added to this crude material to make a solid deposit after evaporation of the EtOH. A silica gelcolumn chromatography (eluent: PE-EtOAc, 95:5) finally afforded the pure nitrile together with the cyclic imide. Conversion into the desired nitrile was determined by 1H NMR analysis of the crude mixture. Given yields were reported for isolated products (Table 2). |
Reference:
[1]Cartigny, Damien; Dos Santos, Aurelie; El Kaim, Laurent; Grimaud, Laurence; Jacquot, Roland; Marion, Philippe
[Synthesis, 2014, vol. 46, # 13, p. 1802 - 1806]