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Chemical Structure| 39515-51-0 Chemical Structure| 39515-51-0
Chemical Structure| 39515-51-0

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3-Phenoxybenzaldehyde is an organic aromatic compound used mainly in synthesizing pesticides and drug intermediates. It shows antimicrobial and antifungal activity by inhibiting bacterial and fungal cell wall synthesis, disrupting cell membrane function, and interfering with DNA synthesis.

Synonyms: m-Phenoxybenzaldehyde

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Product Details of 3-Phenoxybenzaldehyde

CAS No. :39515-51-0
Formula : C13H10O2
M.W : 198.22
SMILES Code : C1=C(C=CC=C1OC2=CC=CC=C2)C=O
Synonyms :
m-Phenoxybenzaldehyde
MDL No. :MFCD00003353
InChI Key :MRLGCTNJRREZHZ-UHFFFAOYSA-N
Pubchem ID :38284

Safety of 3-Phenoxybenzaldehyde

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of 3-Phenoxybenzaldehyde

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 39515-51-0 ]

[ 39515-51-0 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 2298-36-4 ]
  • [ 39515-51-0 ]
  • [4-(3-phenoxy-benzylamino)-phenoxy]-acetic acid [ No CAS ]
  • 2
  • [ 117011-70-8 ]
  • [ 39515-51-0 ]
  • 2-methyl-2-[4-(3-phenoxy-benzylamino)-phenoxy]-propionic acid [ No CAS ]
  • 3
  • [ 1135-40-6 ]
  • [ 51631-50-6 ]
  • [ 39515-51-0 ]
  • [ 51630-58-1 ]
YieldReaction ConditionsOperation in experiment
In n-heptane; water; EXAMPLE 2 Preparation of α-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methyl butanoate using 3-(cyclohexylamino)-propanesulfonic acid as the rate-promoting agent A flask was charged with 3-(cyclohexylamino)propanesulfonic acid (42 mg), 3-phenoxybenzaldehyde (1.90 g, 9.6 mmole), sodium cyanide (0.56 g, 12 mmole), 1 ml water, and 15 ml n-heptane. 2-(4-Chlorophenyl)-3-methylbutanoyl chloride (2.34 g, 10.1 mmole) in 5 ml n-heptane was added dropwise over a period of 24 minutes to the stirred mixture. Thirty minutes after the addition was complete, a total of 54 minutes, glpc indicated a 95.6% yield of the desired ester. After stirring overnight, the reaction mixture was filtered and extracted with ether. The ether was evaporated from the extract, affording α-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methyl butanoate (3.47 g).
In n-heptane; water; EXAMPLE 2 Preparation of α-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methyl butanoate using 3-(cyclohexylamino)propanesulfonic acid as the rate-promoting agent A flask was charged with 3-(cyclohexylamino)propanesulfonic acid (42 mg), 3-phenoxybenzaldehyde (1.90 g, 9.6 mmole), sodium cyanide (0.56 g, 12 mmole), 1 ml water, and 15 ml n-heptane. 2-(4-Chlorophenyl)-3-methylbutanoyl chloride (2.34 g, 10.1 mmole) in 5 ml n-heptane was added dropwise over a period of 24 minutes to the stirred mixture. Thirty minutes after the addition was complete, a total of 54 minutes, glpc indicated a 95.6% yield of the desired ester. After stirring overnight, the reaction mixture was filtered and extracted with ether. The ether was evaporated from the extract, affording α-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methyl butanoate (3.47 g).
  • 4
  • [ 3083-10-1 ]
  • [ 51631-50-6 ]
  • [ 39515-51-0 ]
  • [ 51630-58-1 ]
YieldReaction ConditionsOperation in experiment
In n-heptane; water; B. Using 2,5,8,11-tetramethyl-2,5,8,11-tetraazadodecane A flask was charged with 3-phenoxybenzaldehyde (1.98 g, 10 mmole), 20 ml n-heptane, 2,5,8,11-tetramethyl-2,5,8,11-tetraazadodecane (0.046 g), sodium cyanide (0.59 g, 12 mmole), and 1 ml. water. With stirring, 2-(4-chlorophenyl)-3-methylbutanoyl chloride (2.42 g, 10.5 mmole) was added dropwise over a period of 6 minutes. The reaction mixture was stirred at room temperature. Analysis by glpc 2.4 hr. after the acyl chloride had been added indicated a 67.7% yield of the desired ester. Stirring was continued overnight, and the desired ester (3.4 g) was isolated as described in the preceding Example.
  • 5
  • [ 51631-50-6 ]
  • [ 39515-51-0 ]
  • [ 51630-58-1 ]
YieldReaction ConditionsOperation in experiment
91% In tetrahydrofuran; n-heptane; water; A. Using Tetrahydrofuran To a stirred solution of sodium cyanide (0.74 g, 0.015 mole) in a 1:1 by volume mixture of water and tetrahydrofuran (20 ml) at 30 was added all at once 3-phenoxybenzaldehyde (1.98 g, 0.01 mole) in the same solvent system (5 ml), followed by the dropwise addition of 2-(4-chlorophenyl)-3-methylbutanoyl chloride (2.77 g, 0.012 mole). Stirring was continued at 30 for an additional 2 hours, after which the mixture was cooled to room temperature and extracted thrice with heptane (25 ml each). The combined organic layers were washed once with aqueous 2 N NaOH (25 ml), then four times with water (25 ml each) to a final wash pH of about 6, dried over Na2 SO4, and concentrated to give the desired product (3.90 g, 93% yield). When the experiment was repeated under substantially the same conditions the weight yield was 91%.
With NaCN; In n-heptane; water; toluene; EXAMPLE I. Preparation of α-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutanoate A 50 ml round-bottomed flask equipped with a magnetic stirrer was charged with 10 mmol of 3-phenoxybenzaldehyde, 10 mmol of 2-(4-chlorophenyl)-3-methylbutanoyl chloride, 12 mmol of sodium cyanide, 1.00 ml of water and 20 ml of n-heptane. The molar ratio of water to sodium cyanide was 4.64, all NaCN being dissolved. The reaction mixture was stirred and analyzed. The yield of the ester wanted is presented in Table I (experiment 1). Experiment 2 is a repetition of experiment 1, the difference being that 20 ml of toluene was used instead of 20 ml of n-heptane and 10.5 mmol of the acyl halide instead of 10 mmol. The yield of the desired ester is presented in Table I. Comparisons of the yields show that n-heptane is the best solvent.
  • 6
  • [ 144-55-8 ]
  • [ 51631-50-6 ]
  • [ 39515-51-0 ]
  • [ 51630-58-1 ]
YieldReaction ConditionsOperation in experiment
99% In n-heptane; water; EXAMPLE IV Preparation of α-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutanoate on an enlarged scale Methods A (not according to the invention), and B were compared for the preparation of the ester wanted. Method A, in the absence of a phase transfer catalyst. A 500 ml round-bottomed flask equipped with a paddle stirrer was charged with 100 mmol of 3-phenoxybenzaldehyde, 100 mmol of 2-(4-chlorophenyl)-3-methylbutanoyl chloride, 120 mmol of sodium cyanide, 10 ml of water (which dissolved all sodium cyanide) and 200 ml of n-heptane. After stirring for 45 hours the mixture was warmed to a temperature between 40 and 50 C and filtered. The filtrate was washed twice with 50 ml of a 1 M aqueous sodium bicarbonate solution, once with 50 ml of water, dried and the n-heptane was flashed from the dried solution to give the desired ester in a yield of 99% and a purity of 96%.
With NaCN; In n-heptane; water; EXAMPLE 6 Preparation of α-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutanoate on an enlarged scale A 500 ml round-bottomed flask equipped with a paddle stirrer was charged with 100 mmol of 3-phenoxybenzaldehyde, 100 mmol of 2-(4-chlorophenyl)-3-methylbutanoyl chloride, 120 mmol of sodium cyanide, 10 ml of water, and 200 ml of n-heptane. The molar ratio of water to sodium cyanide was 4.64, all NaCN being dissolved. The mixture thus formed was stirred and analyzed. Table VI presents the yields and purities of the desired ester after the reaction time indicated. The reaction mixture obtained in experiment 1 was warmed to a temperature between 40 and 50 C and filtered. The filtrate was washed twice with 50 ml of a 1 M aqueous sodium bicarbonate solution, once with 50 ml of water, dried and n-heptane was flashed from the dried solution to give the desired ester.
  • 7
  • [ 57497-39-9 ]
  • [ 39515-51-0 ]
  • [ 1172128-74-3 ]
  • 8
  • [ 66230-04-4 ]
  • [ 1745-18-2 ]
  • [ 622-98-0 ]
  • [ 1875-88-3 ]
  • [ 2012-74-0 ]
  • [ 23853-78-3 ]
  • [ 3739-38-6 ]
  • [ 938-95-4 ]
  • [ 39515-51-0 ]
  • [ 873-76-7 ]
  • methyl N-hydroxybenzene carboximidoate [ No CAS ]
  • 9
  • [ 1198-14-7 ]
  • [ 55-21-0 ]
  • [ 39515-51-0 ]
  • N-((5-bromo-8-hydroxyquinolin-7-yl)(3-phenoxyphenyl)methyl)benzamide [ No CAS ]
  • 10
  • [ 1198-14-7 ]
  • [ 103-81-1 ]
  • [ 39515-51-0 ]
  • N-((5-bromo-8-hydroxyquinolin-7-yl)(3-phenoxyphenyl)methyl)-2-phenylacetamide [ No CAS ]
 

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