[ CAS No. 873-76-7 ]

Name: 873-76-7|(4-Chlorophenyl)methanol|98%
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Quality Control of [ 873-76-7 ]

COA NMR CNMR HPLC LC-MS

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Alternatived Products of [ 873-76-7 ]

Product Details of [ 873-76-7 ]

CAS No. :	873-76-7	MDL No. :	MFCD00004652
Formula :	C₇H₇ClO	Boiling Point :	234°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	-
M.W :	142.58 g/mol	Pubchem ID :	13397
Synonyms :

Calculated chemistry of of [ 873-76-7 ]

Physicochemical Properties

Num. heavy atoms :	9
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.14
Num. rotatable bonds :	1
Num. H-bond acceptors :	1.0
Num. H-bond donors :	1.0
Molar Refractivity :	37.58
TPSA :	20.23 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.78 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.92
Log Po/w (XLOGP3) :	1.96
Log Po/w (WLOGP) :	1.68
Log Po/w (MLOGP) :	2.14
Log Po/w (SILICOS-IT) :	2.33
Consensus Log Po/w :	2.01

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.39
Solubility :	0.586 mg/ml ; 0.00411 mol/l
Class :	Soluble
Log S (Ali) :	-2.01
Solubility :	1.39 mg/ml ; 0.00977 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.82
Solubility :	0.217 mg/ml ; 0.00152 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.0

Safety of [ 873-76-7 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 873-76-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 873-76-7 ]
Downstream synthetic route of [ 873-76-7 ]

[ 873-76-7 ] Synthesis Path-Upstream 1~23

1
[ 873-76-7 ]
[ 16687-61-9 ]

Reference： [1] Journal of Chemical Research, 2017, vol. 41, # 1, p. 25 - 29

2
[ 104-88-1 ]
[ 104-86-9 ]
[ 873-76-7 ]

Reference： [1] Organic Letters, 2002, vol. 4, # 12, p. 2055 - 2058
[2] Tetrahedron, 2008, vol. 64, # 7, p. 1213 - 1217

3
[ 873-76-7 ]
[ 104-86-9 ]

Reference： [1] ChemCatChem, 2018, vol. 10, # 9, p. 1993 - 1997
[2] Organic Letters, 2014, vol. 16, # 2, p. 484 - 487
[3] Organic Letters, 2014, vol. 16, # 17, p. 4424 - 4427

4
[ 623-03-0 ]
[ 21913-13-3 ]
[ 104-86-9 ]
[ 873-76-7 ]

Reference： [1] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 8, p. 2097 - 2101
[2] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 8, p. 2097 - 2101

5
[ 619-56-7 ]
[ 104-86-9 ]
[ 873-76-7 ]

Reference： [1] Chemical and Pharmaceutical Bulletin, 1994, vol. 42, # 2, p. 402 - 404

6
[ 873-76-7 ]
[ 25026-34-0 ]

Reference： [1] Scientia Pharmaceutica, 2001, vol. 69, # 4, p. 329 - 350

7
[ 141-97-9 ]
[ 57-13-6 ]
[ 873-76-7 ]
[ 5948-71-0 ]

Yield	Reaction Conditions	Operation in experiment
82%	Stage #1: With T₃P; dimethyl sulfoxide In ethyl acetate at 20℃; Inert atmosphere; Green chemistry Stage #2: at 60 - 70℃; Inert atmosphere; Green chemistry	General procedure: To a solution of alcohol (1.0 mmol) in a mixture of solvents ethyl acetate (4 mL) and DMSO (2 mL), was added T3P® (2 mmol, 50 percent solution in ethyl acetate), the resulting reaction mixture was stirred at room temperature for 1-2 h under nitrogen atmosphere. The reaction was monitored by TLC. β-ketoester/β-oxodithioester (1.0 mmol) and urea (1.5 mmol) were added and stirred further 4-6 h at 60-70 °C. After completion of the reaction, solvent was evaporated and mixture was poured into crushed ice. Stirring was continued for several minutes. The solid product was filtered, washed with cold water and recrystallized from ethanol to get pure product.

Reference： [1] European Journal of Organic Chemistry, 2015, vol. 2015, # 32, p. 6994 - 6998
[2] Heterocycles, 2005, vol. 65, # 4, p. 767 - 773
[3] Chemistry Letters, 2014, vol. 43, # 2, p. 178 - 180

8
[ 873-76-7 ]
[ 5948-71-0 ]

Reference： [1] Letters in Organic Chemistry, 2018, vol. 15, # 4, p. 241 - 245

9
[ 873-76-7 ]
[ 790-41-0 ]

Reference： [1] New Journal of Chemistry, 2017, vol. 41, # 3, p. 931 - 939
[2] Tetrahedron Letters, 2017, vol. 58, # 26, p. 2533 - 2536

10
[ 10442-39-4 ]
[ 873-76-7 ]
[ 140-53-4 ]

Reference： [1] Journal of Organic Chemistry, 2004, vol. 69, # 7, p. 2562 - 2564

11
[ 873-76-7 ]
[ 140-53-4 ]

Reference： [1] Bulletin of the Chemical Society of Japan, 2006, vol. 79, # 7, p. 1106 - 1117
[2] Chemistry Letters, 2004, vol. 33, # 9, p. 1192 - 1193
[3] Scientia Pharmaceutica, 2001, vol. 69, # 4, p. 329 - 350

12
[ 106-43-4 ]
[ 2420-26-0 ]
[ 5306-98-9 ]
[ 615-74-7 ]
[ 104-88-1 ]
[ 873-76-7 ]

Reference： [1] Journal of the Chemical Society. Perkin Transactions 2, 1996, vol. 4, p. 551 - 556

13
[ 899426-20-1 ]
[ 16251-45-9 ]
[ 873-76-7 ]

Reference： [1] Chemistry - A European Journal, 2006, vol. 12, # 14, p. 3896 - 3904

14
[ 66230-04-4 ]
[ 1745-18-2 ]
[ 622-98-0 ]
[ 1875-88-3 ]
[ 2012-74-0 ]
[ 23853-78-3 ]
[ 3739-38-6 ]
[ 938-95-4 ]
[ 39515-51-0 ]
[ 873-76-7 ]

Reference： [1] Journal of the Brazilian Chemical Society, 2015, vol. 26, # 9, p. 1831 - 1837

15
[ 873-76-7 ]
[ 874-89-5 ]

Reference： [1] Angewandte Chemie - International Edition, 2013, vol. 52, # 38, p. 10035 - 10039[2] Angew. Chem., 2013, vol. 125, # 38, p. 10219 - 10223

16
[ 873-76-7 ]
[ 874-89-5 ]

Reference： [1] Organometallics, 2013, vol. 32, # 12, p. 3537 - 3543

17
[ 1126-46-1 ]
[ 4068-78-4 ]
[ 22717-55-1 ]
[ 873-76-7 ]

Reference： [1] Organic and Biomolecular Chemistry, 2008, vol. 6, # 7, p. 1251 - 1259

18
[ 873-76-7 ]
[ 73183-34-3 ]
[ 302348-51-2 ]

Reference： [1] RSC Advances, 2018, vol. 8, # 25, p. 13643 - 13648

19
[ 1692-25-7 ]
[ 873-76-7 ]
[ 127406-55-7 ]

Reference： [1] Dalton Transactions, 2014, vol. 43, # 26, p. 10235 - 10247

20
[ 5720-06-9 ]
[ 873-76-7 ]
[ 421553-62-0 ]

Reference： [1] Dalton Transactions, 2014, vol. 43, # 26, p. 10235 - 10247

21
[ 873-76-7 ]
[ 73183-34-3 ]
[ 517920-59-1 ]

Reference： [1] Organic Letters, 2017, vol. 19, # 5, p. 1204 - 1207

22
[ 873-76-7 ]
[ 375854-57-2 ]

Reference： [1] Organic and Biomolecular Chemistry, 2013, vol. 11, # 9, p. 1463 - 1467

23
[ 873-76-7 ]
[ 1268524-70-4 ]

Reference： [1] Patent: , 2016, ,

[ 873-76-7 ] Synthesis Path-Downstream 1~31

1
[ 1878-66-6 ]
[ 52449-43-1 ]
[ 1195-44-4 ]
[ 3395-81-1 ]
[ 104-88-1 ]
[ 873-76-7 ]

Reference： [1]Synthetic Communications,1990,vol. 20,p. 1843 - 1852

2
[ 790-41-0 ]
[ 873-76-7 ]
[ 74-11-3 ]

Reference： [1]Synthesis,1987,p. 647 - 648

4
[ 899426-20-1 ]
[ 16251-45-9 ]
[ 873-76-7 ]
3-methylsulafanyl-3-phenylpropan-1-ol [ No CAS ]

Reference： [1]Chemistry - A European Journal,2006,vol. 12,p. 3896 - 3904

5
[ 873-76-7 ]
[ 831-81-2 ]

Reference： [1]Organic Letters,2005,vol. 7,p. 4875 - 4878
[2]Synlett,2014,vol. 25,p. 2928 - 2932

6
[ 790-41-0 ]
curvularin [ No CAS ]
[ 873-76-7 ]

Reference： [1]Synthesis,1987,p. 647 - 648

7
[ 63624-48-6 ]
[ 85-81-4 ]
[ 52824-29-0 ]
[ 68-12-2 ]
[ 873-76-7 ]
[ 63624-56-6 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; hydrazine hydrate; hydroquinone;aluminum nickel; In ethanol; toluene;	A. 8-Amino-2-(4-chlorobenzyloxy)-6-methoxyquinoline. 6-Methoxy-8-nitroquinoline was converted into 2-chloro-<strong>[85-81-4]6-methoxy-8-nitroquinoline</strong>: K. Mislow and J. B. Koepfli, J. Amer. Chem. Soc., 68, 1553 (1946); R. E. Lyle, et al., J. Org. Chem., 37, 3967 (1972). A mixture of 48 g (0.2 mole) of 2-chloro-<strong>[85-81-4]6-methoxy-8-nitroquinoline</strong>, 42.78 g (0.3 mole) of 4-chlorobenzyl alcohol, 27.6 g (0.2 mole) of anhydrous potassium carbonate, and 200 ml N,N-dimethyl formamide was heated under nitrogen at ca. 155-160 for 18 hr. The mixture was cooled, diluted with ice water, stirred, collected, and washed with water. The crude solid was leached with a little 95% ethanol at 70 and then recrystallized from that solvent. A 84% yield of 2-(4-chlorobenzyloxy)-<strong>[85-81-4]6-methoxy-8-nitroquinoline</strong> resulted; mp 129.5-133.5. The foregoing nitro compound (34.48 g, 0.1 mole), 500 ml of a 1:1 mixture (v/v) of toluene and ethanol, 10 g wet Raney nickel, and 50 ml 85% hydrazine hydrate was refluxed for 6 hr. Thereafter, the condenser was placed for distillation and heated until vapors at the still-head were alkaline. A small amount of hydroquinone was added, and the hot mixture filtered. The filtrates were concentrated in vacuo, leached with a little warm ethanol, then crystallized from ethanol (charcoal). The 8-amino-2-(4-chlorobenzyloxy)-6-methoxyquinoline was obtained in 97% yield; mp 123.5-125.

Reference： [1]Patent: US4167638,1979,A

8
[ 5451-09-2 ]
[ 873-76-7 ]
[ 396078-83-4 ]

Yield	Reaction Conditions	Operation in experiment
0.56 g (32%)		4-Chlorobenzyl 5-amino-4-oxopentanoate Hydrochloride [Compound 19] From 4-chlorobenzyl alcohol (5.0 g; 35 mmol) and <strong>[5451-09-2]5-amino-4-oxopentanoic acid hydrochloride</strong> (1.0 g; 6.0 mmol). The reaction was complete after 24 h at 100 C. The yield was 0.56 g (32%). Mp 127-129 C. 1H NMR (200 MHz; DMSO-d6): delta 2.65 (2H, t, J=5.8 Hz), 2.89 (2H, t, J=6.0 Hz), 3.99 (2H, br s), 5.11 (2H, s), 7.44 (4H, s), 8.56 (3H, br s). 13C NMR (50 MHz; DMSO-d6): delta 27.1, 34.3, 46.5, 64.7, 128.4, 129.7, 132.6, 135.1, 171.8, 202.5.

Reference： [1]Patent: US2004/106679,2004,A1

9
[ 32675-71-1 ]
[ 873-76-7 ]
[ 1194630-02-8 ]

Reference： [1]Angewandte Chemie - International Edition,2009,vol. 48,p. 7025 - 7029
Angewandte Chemie,2009,vol. 121,p. 7159 - 7163

10
[ 68-12-2 ]
[ 873-76-7 ]
[ 14062-80-7 ]

Yield	Reaction Conditions	Operation in experiment
87%	With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In 1,1,2-trichloroethane; water; at 90℃; for 12h;	General procedure: To a solution of alcohols 1 (0.1 mmol) in TCE (1.0 mL) was added n-Bu4NI (20 mol%) and N, N-disubstituted formamides 2 (0.5 mmol), followed by adding a solution of TBHP (6.0 equiv., 70% aqueous solution). The resulting mixture was stirred at 90 oC until it completed. When the reaction was finished, the reaction mixture was cooled to room temperature and poured into saturated Na2S2O3 solution (3.0 mL), extracted with EtOAc (3×8.0 mL), then washed with saturated brine. The combined organic layers were dried over anhydrous Na2SO4. After removing the solvents in vacuo, the residue was purified by flash column chromatography on silica gel or preparative TLC on GF 254 to afford the desired products 3.

Reference： [1]Tetrahedron Letters,2012,vol. 53,p. 6479 - 6482,4
[2]Chemistry - A European Journal,2012,vol. 18,p. 9793 - 9797
[3]Applied Organometallic Chemistry,2019,vol. 33
[4]Inorganic Chemistry,2017,vol. 56,p. 10596 - 10608

11
potassium cyanide [ No CAS ]
[ 873-76-7 ]
[ 874-89-5 ]

Reference： [1]Organometallics,2013,vol. 32,p. 3537 - 3543

12
potassiumhexacyanoferrate(II) trihydrate [ No CAS ]
[ 873-76-7 ]
[ 874-89-5 ]

Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 10035 - 10039
Angew. Chem.,2013,vol. 125,p. 10219 - 10223

13
[ 117570-53-3 ]
[ 873-76-7 ]
[ 1415113-23-3 ]

Reference： [1]MedChemComm,2014,vol. 5,p. 512 - 520

14
[ 1692-25-7 ]
[ 873-76-7 ]
[ 127406-55-7 ]

Reference： [1]Dalton Transactions,2014,vol. 43,p. 10235 - 10247

15
[ 108-86-1 ]
[ 873-76-7 ]
[ 831-81-2 ]

Reference： [1]Chemical Science,2015,vol. 6,p. 1115 - 1119

16
[ 124-40-3 ]
[ 873-76-7 ]
[ 14062-80-7 ]

Yield	Reaction Conditions	Operation in experiment
88%	With tert.-butylhydroperoxide; [bis(acetoxy)iodo]benzene; In acetonitrile;Reflux;	General procedure: To a mixture of aryl alcohol (1.0 mmol), appropriate amine (2.5 mmol) and TBHP (70 wt % in H2O, 8.0 mmol) in acetonitrile (5 mL), was added DIB (0.2 mmol, 20 mol %) at room temperature. The reaction was allowed to stir at reflux temperature for 5-6 h. After the reaction was complete, as indicated by TLC, the mixture was cooled to room temperature. The volatiles were removed under reduced pressure and 10 mL saturated solution of NaHCO3 was added. The mixture was extracted with ethylacetate (310 mL). The combined organic phases were dried with Na2SO4 and evaporated under vacuum. Purification of the residue by column chromatography (petroleum ether/EtOAc) afforded the desired amide.

Reference： [1]Tetrahedron Letters,2015,vol. 56,p. 6768 - 6771

17
[ 1532-71-4 ]
[ 873-76-7 ]
[ 16576-24-2 ]

Yield	Reaction Conditions	Operation in experiment
95.4%	With ammonium cerium (IV) nitrate; bis(tricyclohexylphosphine)nickel(II) dichloride; 2,2-bis(hydroxymethyl)propionic acid; strontium nitrate; cadmium(II) acetate; In ethylene glycol; at 70℃; for 8h;Inert atmosphere;	Under room temperature, the nitrogen atmosphere, to the proper amount of organic solvent glycol, by adding 100mmol compounds represented by the following general formula (I) compound, 150mmol aboving (II) compound, 12mmol catalyst NiCl 2 (PCy 3) 2, 200mmol oxidant ammonium ceric nitrate, 175mmol alkali DMPA and 15mmol promoter (for 3mmol cadmium acetate and 12mmol strontium nitrate of mixture), then heating to 70 °C, and at this temperature the stirring reaction 8 hours; After the reaction, the reaction solution is filtered, adjusted to neutral pH value of the filtrate, saturated salt water is then used to fully wash, then adding ethyl acetate extraction 2-3 time, combined with the phase, drying anhydrous sodium sulfate, concentrated under reduced pressure, the resulting residue over silica gel column chromatography, so as to the acetone and volume ratio of the mixed solution of petroleum ether eluviation, so as to obtain the compound of formula (III), the yield is 95.4percent.

Reference： [1]Patent: CN105481768,2016,A .Location in patent: Paragraph 0039; 0040; 0041; 0042; 0043

18
[ 873-76-7 ]
[ 1268524-70-4 ]

Reference： [1]Patent: ,2016,

19
[ 1115-70-4 ]
[ 873-76-7 ]
[ 43153-46-4 ]

Reference： [1]New Journal of Chemistry,2016,vol. 40,p. 8225 - 8228

20
[ 657-36-3 ]
[ 873-76-7 ]
(4-chlorophenyl)(4-(trifluoromethyl)piperidin-1-yl)methanone [ No CAS ]
[ 74-11-3 ]

Reference： [1]Journal of Organic Chemistry,2016,vol. 81,p. 10688 - 10697

21
[ 657-36-3 ]
[ 873-76-7 ]
(4-chlorophenyl)(4-(trifluoromethyl)piperidin-1-yl)methanone [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2016,vol. 81,p. 10688 - 10697

22
[ 873-76-7 ]
[ 138007-24-6 ]
tert-butyl 1-(4-chlorobenzoyl)piperidine-4-carboxylate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2016,vol. 81,p. 10688 - 10697

23
[ 873-76-7 ]
[ 16687-61-9 ]

Reference： [1]Journal of Chemical Research,2017,vol. 41,p. 25 - 29

24
[ 873-76-7 ]
[ 790-41-0 ]

Reference： [1]New Journal of Chemistry,2017,vol. 41,p. 931 - 939
[2]Tetrahedron Letters,2017,vol. 58,p. 2533 - 2536

25
[ 873-76-7 ]
[ 73183-34-3 ]
[ 517920-59-1 ]

Reference： [1]Organic Letters,2017,vol. 19,p. 1204 - 1207

26
[ 873-76-7 ]
[ 73183-34-3 ]
[ 302348-51-2 ]

Reference： [1]RSC Advances,2018,vol. 8,p. 13643 - 13648

27
[ 591-50-4 ]
[ 873-76-7 ]
[ 831-81-2 ]

Reference： [1]Organic Letters,2018,vol. 20,p. 7846 - 7850

28
[ 105-45-3 ]
[ 873-76-7 ]
[ 73257-49-5 ]

Yield	Reaction Conditions	Operation in experiment
96%	With ammonium hydroxide; hydrogen bromide; dimethyl sulfoxide; In water; at 75℃; for 2.53333h;	General procedure: A mixture of HBr (48% aq., 1 mmol) in DMSO (1 mL) was stirred for 2 min at 75 C. Then, benzylic alcohol (1 mmol), alkyl acetoacetate (2 mmol), and ammonium hydroxide (1.5 mmol) were added to the reaction mixture and stirring was continued at 75 C for 2.5 h. The completion of reaction was followed by TLC. After the reaction was complete, the reaction mixture was cooled to ambient temperature, quenched by addition of water (2 mL), and stirring was continued for 10 min at ambient temperature. The resulting precipitate was filtered, washed with water, dried, and recrystallized from ethanol to afford the pure product 4.

Reference： [1]Tetrahedron Letters,2018,vol. 59,p. 4102 - 4106

29
[ 14062-80-7 ]
[ 873-76-7 ]

Reference： [1]Angewandte Chemie - International Edition,2019,vol. 58,p. 4992 - 4997
Angew. Chem.,2019,vol. 131,p. 5046 - 5051,6

30
[ 590-92-1 ]
[ 873-76-7 ]
4-chlorobenzyl 3-bromopropanoate [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2019,vol. 141,p. 17117 - 17124

31
[ 873-76-7 ]
[ 73257-49-5 ]

Reference： [1]New Journal of Chemistry,2020,vol. 44,p. 1508 - 1516

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Ghs Precautionary Statements

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P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 873-76-7 ]

Quality Control of [ 873-76-7 ]

Related Doc. of [ 873-76-7 ]

Product Details of [ 873-76-7 ]

Calculated chemistry of of [ 873-76-7 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 873-76-7 ]

Application In Synthesis of [ 873-76-7 ]

[ 873-76-7 ] Synthesis Path-Upstream 1~23

[ 873-76-7 ] Synthesis Path-Downstream 1~31

Related Functional Groups of [ 873-76-7 ]

Chlorides

Aryls

Alcohols

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 873-76-7 ]