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Chemical Structure| 396075-80-2 Chemical Structure| 396075-80-2

Structure of 396075-80-2

Chemical Structure| 396075-80-2

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Product Details of [ 396075-80-2 ]

CAS No. :396075-80-2
Formula : C7H9FN2
M.W : 140.16
SMILES Code : NNC1=CC=CC(F)=C1C
MDL No. :MFCD07786571

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Application In Synthesis of [ 396075-80-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 396075-80-2 ]

[ 396075-80-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 443-86-7 ]
  • [ 7772-99-8 ]
  • [ 396075-80-2 ]
YieldReaction ConditionsOperation in experiment
34% With sodium hydroxide; sodium hydrogencarbonate; sodium nitrite; In hydrogenchloride; water; e (3-Fluoro-2-methyl-phenyl)-hydrazine 24 g 3-Fluoro-2-methyl-aniline was added to 120 ml 25percent hydrochloric acid and the mixture cooled to 0° C. A solution of 15 g sodium nitrite in 80 ml water was added dropwise to the resulting suspension at such a rate that the temperature did not rise above 8° C. When the addition was complete, the mixture was stirred 1 h at 0° C. Whilst maintaining the mixture at 0° C., a suspension of 195 g tin (II) chloride in 230 ml 25percent aqueous hydrochloric acid was added over 30 min. The mixture was stirred a further 20 min, and the precipitate that formed was filtered. The crude hydrochloride salt was partitioned between water and dichloromethane, and the pH raised to pH8 by the addition of sodium hydroxide solution followed by saturated sodium bicarbonate solution. The phases were separated, the aqueous phase extracted twice with dichloromethane and the combined organic phases dried over sodium sulfate and evaporated. The resulting solid residue was recrystallized from hexane to afford the title compound as a light brown solid (9.2 g, 34percent yield, mp 69° C.; EI-MS m/e: 140.1 (M+)).
 

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