[ CAS No. 39652-31-8 ] {[proInfo.proName]}

Name: 39652-31-8|(2-Chloro-4-methylphenyl)methanol|97%
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Product Details of [ 39652-31-8 ]

CAS No. :	39652-31-8	MDL No. :	MFCD18393674
Formula :	C₈H₉ClO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	VVAVRWRWRCLETL-UHFFFAOYSA-N
M.W :	156.61	Pubchem ID :	15544016
Synonyms :

Safety of [ 39652-31-8 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362	UN#:
Hazard Statements:	H315-H319	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 39652-31-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 39652-31-8 ]
Downstream synthetic route of [ 39652-31-8 ]

[ 39652-31-8 ] Synthesis Path-Upstream 1~1

1
[ 39652-31-8 ]
[ 50817-80-6 ]

Reference： [1] ChemCatChem, 2017, vol. 9, # 20, p. 3880 - 3887

[ 39652-31-8 ] Synthesis Path-Downstream 1~27

Yield	Reaction Conditions	Operation in experiment
	4-Methylbenzylalkohol, NaClO2 (in 2n H2SO4);
	With diborane In tetrahydrofuran at 0 - 20℃;	130.A A. 2,3-dihydro-l-benzofuran-7-ylmethanol General procedure: A. 2,3-dihydro-l-benzofuran-7-ylmethanol [00878] Added BH3 (1M in THF, 9 mL) to a solution of 2,3-dihydro-l-benzofuran-7- carboxylic acid (481 mg, 2.93 mmol) in THF (7 mL) drop wise at 0°C, thereto, the mixture was stirred at room temperature overnight. Extracted with ethyl acetate twice, and washed the organic phase with brine and dried with anhydrous Na2S04, concentrated to give the title compound (340 mg, 77%). 1H NMR (400 MHz, CDC13): δ 2.09 (1H, s), 3.22 (2H, t, J= 8.8 Hz), 4.61 (2H, t, J= 8.8 Hz), 4.67 (2H, s), 6.83 (1H, t, J= 7.6 Hz), 7.08 (1H, d, J= 7.2 Hz), 7.14 (1H, d, J= 7.2 Hz).

2
[ 39652-31-8 ]
[ 124-63-0 ]
[ 219764-31-5 ]

Yield	Reaction Conditions	Operation in experiment
100%	With triethylamine In tetrahydrofuran at 0 - 20℃; for 3h;
		69.1 Preparation Example 69-1 2-Chloro-1-((methanesulfonyloxy)methyl)-4-methylbenzene In the same manner as in Preparation Example 14-1, the objective compound (383 mg) was obtained as a colorless oil from 2-chloro-4-methylbenzyl alcohol (259 mg). 1H-NMR(CDCl3): 2.35(3H, s), 2.98(3H, s), 5.31(2H, s), 7.11(1H, d, J=8 Hz), 7.26(1H, s), 7.36(1H, d, J=8 Hz)

Reference： [1]Ikeda, Shuhei; Sugiyama, Hideyuki; Tokuhara, Hidekazu; Murakami, Masataka; Nakamura, Minoru; Oguro, Yuya; Aida, Jumpei; Morishita, Nao; Sogabe, Satoshi; Dougan, Douglas R.; Gay, Sean C.; Qin, Ling; Arimura, Naoto; Takahashi, Yasuko; Sasaki, Masako; Kamada, Yusuke; Aoyama, Kazunobu; Kimoto, Kouya; Kamata, Makoto [Journal of Medicinal Chemistry, 2021, vol. 64, # 15, p. 11014 - 11044]
[2]Current Patent Assignee: ASTELLAS PHARMA INC. - US6348474, 2002, B1 Location in patent: Page column 102

3
[ 39652-31-8 ]
[ 75-36-5 ]
[ 1198016-65-7 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine In dichloromethane at 0 - 20℃;	18.b (b) (2-chloro-4-methylphenyl)methyl acetateTo a solution of (2-chloro-4-methylphenyl)methanol (365 mg, 2.331 mmol) and Et3N (0.390 mL, 2.80 mmol) in Dichloromethane (DCM) (10 mL) at 0° C. AcOCl (0.331 mL, 4.66 mmol) was slowly added and the mixture was left under stirring at 0° C. for 1 hour then at room temperature overnight. Next morning HPLC showed no starting material remaining volatiles were removed under vacuum and resulting crude was dissolved in DCM washed several times with water. Organic layers were dried over Na2SO4 and volatiles removed to afford 453 mg of the final compound as a brown oil.1H-NMR (δ ppm, CDCl3): 7.30 (d, 1H), 7.06 (s, 1H), 5.11 (s, 2H), 2.33 (s, 3H), 2.11 (s, 3H).

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - US2009/306089, 2009, A1 Location in patent: Page/Page column 37

4
[ 195318-63-9 ]
[ 39652-31-8 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: methyl 2-chloro-4-methylbenzoate With diisobutylaluminium hydride In dichloromethane at 0 - 20℃; Inert atmosphere; Stage #2: With rochelle salt In dichloromethane for 1h;	18.a (a) (2-chloro-4-methylphenyl)methanolMethyl 2-chloro-4-methylbenzoate (520 mg, 2.82 mmol) was dissolved in Dichloromethane (DCM) (15 mL) and at 0° C. Dibal-H (4.694 ml, 7.04 mmol) was slowly added. The mixture was left at 0° C. for 2H and then at room temperature overnight. Next morning HPLC showed no starting material remaining, reaction was quenched with Rochelle salt, and leaving under stirring for 1 hour and then it was extracted with DCM, dried and concentrated to afford 365 mg of the final compound, pure enough to be used in the next step.1H-NMR (δ ppm, CDCl3): 7.35-7.07 (m, 3H), 4.74 (s, 2H), 2.33 (s, 2H).

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - US2009/306089, 2009, A1 Location in patent: Page/Page column 36

5
[ 50817-80-6 ]
[ 39652-31-8 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium tetrahydroborate In tetrahydrofuran; methanol at 0 - 20℃; Inert atmosphere; Schlenk technique; Glovebox;	(2-Chloro-4-methylphenyl)methanol 375 ml of methanol was added dropwise with vigorous stirring over 5 h to a mixture of 116 g (0.75 mol) of 2-chloro-4-methylbenzaldehyde and 43.0 g (1.14 mol) of NaBH4 in 750 ml of THF at 0-5 °C. This mixture was stirred overnight at room temperature, and then evaporated to dryness. The resulting oily mass was acidified with 1200 ml of 2 M HC1 to pH~1, and the formed product was extracted consequently with 3 x 400 ml of dichloromethane. The combined organic extract was dried over Na2S04 and evaporated to dryness. This product was used without further purification.
	With methanol; sodium tetrahydroborate In tetrahydrofuran at 0 - 20℃;	(2-chloro-4-methylphenyl)methanol 375 ml of methanol was added dropwise by vigorous stirring over 5 h to amixture of 116 g (0.75 mol) of 2-chloro-4-methylbenzaldehyde and 43.0 g (1.14mol) of NaBH4 in 750 ml of THF at 0-5°C. This mixture was stirred overnight atroom temperature, and then evaporated to dryness. The resulting oily mass was acidified with 1200 ml of2 M HCl to pH~1, and the formed product was extractedconsequently with 3 x400 ml of dichloromethane. The combined organic extract wasdried over Na2S04 and evaporated to dryness. This product was used withoutadditional purification.1H NMR (CDCh): b 7.29 (d, J = 7.8 Hz, 1H, 5-H), 7.15 (s, 1H, 3-H), 7.04 (d,J= 7.8 Hz, 1H, 6-H), 4.67 (s, 2H, CH20H), 2.59 (br.s, 1H, CH20H), 2.30 (s, 3H, 4-Me). 13CeH} NMR (CDCh): b 138.9, 135.0, 132.4, 129.7, 128.6, 127.6, 62.5, 20.7.

Reference： [1]Current Patent Assignee: OMV AKTIENGESELLSCHAFT; Borealis (in: OMV Group) - WO2014/96282, 2014, A1 Location in patent: Page/Page column 36
[2]Current Patent Assignee: Borealis (in: OMV Group); OMV AKTIENGESELLSCHAFT - WO2018/91684, 2018, A1 Location in patent: Page/Page column 74

6
[ 6627-51-6 ]
[ 39652-31-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -88 °C / Inert atmosphere; Schlenk technique; Glovebox 1.2: 20 °C / Inert atmosphere; Schlenk technique; Glovebox 2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox
	Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -88 °C 1.2: 20 °C 2.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0 - 20 °C

Reference： [1]Current Patent Assignee: OMV AKTIENGESELLSCHAFT; Borealis (in: OMV Group) - WO2014/96282, 2014, A1
[2]Current Patent Assignee: Borealis (in: OMV Group); OMV AKTIENGESELLSCHAFT - WO2018/91684, 2018, A1

7
[ 39652-31-8 ]
[ 1613641-70-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: thionyl chloride / dichloromethane / 5 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox 2.1: sodium ethanolate / ethanol / 0.25 h / Inert atmosphere; Schlenk technique; Glovebox 2.2: 2 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux 2.3: 4 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux 3.1: 160 - 180 °C / Inert atmosphere; Schlenk technique; Glovebox 4.1: thionyl chloride / 24 h / 20 °C / Inert atmosphere; Schlenk technique; Glovebox
	Multi-step reaction with 2 steps 1.1: thionyl chloride / dichloromethane / 5 - 20 °C 2.1: sodium ethanolate / 0.25 h 2.2: 2 h / Reflux

8
[ 39652-31-8 ]
C₁₂H₁₃ClO₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: thionyl chloride / dichloromethane / 5 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox 2.1: sodium ethanolate / ethanol / 0.25 h / Inert atmosphere; Schlenk technique; Glovebox 2.2: 2 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux 2.3: 4 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux

Reference： [1]Current Patent Assignee: OMV AKTIENGESELLSCHAFT; Borealis (in: OMV Group) - WO2014/96282, 2014, A1

9
[ 39652-31-8 ]
[ 1506521-66-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: thionyl chloride / dichloromethane / 5 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox 2.1: sodium ethanolate / ethanol / 0.25 h / Inert atmosphere; Schlenk technique; Glovebox 2.2: 2 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux 2.3: 4 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux 3.1: 160 - 180 °C / Inert atmosphere; Schlenk technique; Glovebox

Reference： [1]Current Patent Assignee: OMV AKTIENGESELLSCHAFT; Borealis (in: OMV Group) - WO2014/96282, 2014, A1

10
[ 39652-31-8 ]
[ 902275-74-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: thionyl chloride / dichloromethane / 5 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox 2.1: sodium ethanolate / ethanol / 0.25 h / Inert atmosphere; Schlenk technique; Glovebox 2.2: 2 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux 2.3: 4 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux 3.1: 160 - 180 °C / Inert atmosphere; Schlenk technique; Glovebox 4.1: thionyl chloride / 24 h / 20 °C / Inert atmosphere; Schlenk technique; Glovebox 5.1: aluminum (III) chloride / dichloromethane / 5 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox
	Multi-step reaction with 3 steps 1.1: thionyl chloride / dichloromethane / 5 - 20 °C 2.1: sodium ethanolate / 0.25 h 2.2: 2 h / Reflux 3.1: aluminum (III) chloride / dichloromethane / 5 - 20 °C

11
[ 39652-31-8 ]
[ 1637287-19-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1.1: thionyl chloride / dichloromethane / 5 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox 2.1: sodium ethanolate / ethanol / 0.25 h / Inert atmosphere; Schlenk technique; Glovebox 2.2: 2 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux 2.3: 4 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux 3.1: 160 - 180 °C / Inert atmosphere; Schlenk technique; Glovebox 4.1: thionyl chloride / 24 h / 20 °C / Inert atmosphere; Schlenk technique; Glovebox 5.1: aluminum (III) chloride / dichloromethane / 5 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox 6.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox
	Multi-step reaction with 4 steps 1.1: thionyl chloride / dichloromethane / 5 - 20 °C 2.1: sodium ethanolate / 0.25 h 2.2: 2 h / Reflux 3.1: aluminum (III) chloride / dichloromethane / 5 - 20 °C 4.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0 - 20 °C

12
[ 39652-31-8 ]
4-chloro-1-methoxy-2,6-dimethylindane [ No CAS ]
4-chloro-1-methoxy-2,6-dimethylindane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 7 steps 1.1: thionyl chloride / dichloromethane / 5 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox 2.1: sodium ethanolate / ethanol / 0.25 h / Inert atmosphere; Schlenk technique; Glovebox 2.2: 2 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux 2.3: 4 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux 3.1: 160 - 180 °C / Inert atmosphere; Schlenk technique; Glovebox 4.1: thionyl chloride / 24 h / 20 °C / Inert atmosphere; Schlenk technique; Glovebox 5.1: aluminum (III) chloride / dichloromethane / 5 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox 6.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox 7.1: potassium hydroxide / dimethyl sulfoxide / 5 h / 20 °C / Inert atmosphere; Schlenk technique; Glovebox

Reference： [1]Current Patent Assignee: OMV AKTIENGESELLSCHAFT; Borealis (in: OMV Group) - WO2014/96282, 2014, A1

13
[ 39652-31-8 ]
[ 2719-39-3 ]

Yield	Reaction Conditions	Operation in experiment
87%	With thionyl chloride In dichloromethane at 5 - 20℃;	2-chloro-1-(chloromethyl)-4-methylbenzene The above-obtained 2-chloro-4-methylbenzyl alcohol dissolved in 750 ml of dichloromethane was added dropwise to 55 ml (754 mmol) of thionyl chloride at+5°C. The resulting solution was stirred overnight at room temperature and thenevaporated to dryness. The residue was dissolved in 500 ml dichloromethane, andthe formed solution was washed by 250 ml of water. The organic layer wasseparated; the aqueous layer was extracted with 2x150 ml of dichloromethane. The combined organic extract was dried over Na2S04, passed through a short pad of silica gel 60 ( 40-63 )liD) and then evaporated to dryness. The crude product wasdistilled in vacuum to give 114 g (87%) of the title product as a colorless liquid, b.p.92-95°C/5 mm Hg.Anal. calc. for CsHsCb: C, 54.89; H, 4.61. Found: C, 54.80; H, 4.65. 1H NMR (CDCh): b 7.30 (d, J= 7.8 Hz, 1H, 5-H), 7.19 (s, 1H, 3-H), 7.04 (d,10J = 7.8 Hz, 1H, 6-H), 4.64 (s, 2H, CHzCl), 2.30 (s, 3H, Me). 13CeH} NMR(CDCh): b 140.3, 133.7, 131.9, 130.6, 130.2, 127.9, 43.5, 20.8.
114 g	With thionyl chloride In dichloromethane at 5 - 20℃; Inert atmosphere; Schlenk technique; Glovebox;	2-Chloro-1-(chloromethyl)-4-methylbenzene The above-obtained 2-chloro-4-methylbenzyl alcohol dissolved in 750 ml of dichloromethane was added dropwise to 55 ml (754 mmol) of thionyl chloride at +5°C. The resulting solution was stirred overnight at room temperature and then evaporated to dryness. The residue was dissolved in 500 ml dichloromethane, and the formed solution was washed with 250 ml of water. The organic layer was separated and the aqueous layer was extracted with 2 x 150 ml of dichloromethane. The combined organic extract was dried over Na2S04, passed through a short pad of silica gel 60 (40-63 μιη), and then evaporated to dryness. Crude product was distilled under vacuum to give 114 g (87%) of the title product as a colorless liquid, b.p. 92-95 °C/5 mm Hg.

Reference： [1]Current Patent Assignee: Borealis (in: OMV Group); OMV AKTIENGESELLSCHAFT - WO2018/91684, 2018, A1 Location in patent: Page/Page column 74; 75
[2]Current Patent Assignee: OMV AKTIENGESELLSCHAFT; Borealis (in: OMV Group) - WO2014/96282, 2014, A1 Location in patent: Page/Page column 37

14
[ 39652-31-8 ]
C₁₁H₉Cl₂N₃O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: phosphorus tribromide / dichloromethane / 0 °C 2: sodium azide / dimethyl sulfoxide / 50 °C 3: copper(II) sulfate; sodium L-ascorbate / water; <i>tert</i>-butyl alcohol / 20 °C / Sealed tube 4: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 20 °C / Inert atmosphere

15
[ 39652-31-8 ]
1-(2-chloro-4-methylbenzyl)-1H-1,2,3-triazole-4-carboxylic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: phosphorus tribromide / dichloromethane / 0 °C 2: sodium azide / dimethyl sulfoxide / 50 °C 3: copper(II) sulfate; sodium L-ascorbate / water; <i>tert</i>-butyl alcohol / 20 °C / Sealed tube

16
[ 39652-31-8 ]
1-(2-chloro-4-methylbenzyl)-N-(4'-((1-methylpiperidin-4-yl)oxy)-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazole-4-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: phosphorus tribromide / dichloromethane / 0 °C 2: sodium azide / dimethyl sulfoxide / 50 °C 3: copper(II) sulfate; sodium L-ascorbate / water; <i>tert</i>-butyl alcohol / 20 °C / Sealed tube 4: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 20 °C / Inert atmosphere 5: pyridine / dichloromethane / 20 °C / Inert atmosphere

17
[ 39652-31-8 ]
C₈H₈ClN₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: phosphorus tribromide / dichloromethane / 0 °C 2: sodium azide / dimethyl sulfoxide / 50 °C
283 mg	Stage #1: (2-chloro-4-methylphenyl)methanol With phosphorus tribromide In dichloromethane at 0℃; for 0.5h; Stage #2: With sodium azide In dimethyl sulfoxide at 50℃;	2.A l-(2-Chloro-4-methylbenzyl)-lH-l,2,3-triazole-4-carboxylic acid (7t) To a solution of 2-chloro-4-methylbenzyl alcohol (626 mg, 4 mmol) in dry DCM (10 mL) was added PBr3 (4.4 mmol) dropwise at 0 °C. The solution was stirred for 30 min at 0 °C and quenched with NaHC03 solution. The organic phase was separated and the aqueous phase extracted with DCM (10 mL x 3). The combined organic phase was washed with brine, dried over Na2S04 and evaporated to dryness. The residue was dissolved in dry DMSO (10 mL), treated with NaN3 (390 mg, 6 mmol) and the mixture was stirred at 50 °C overnight. Then the reaction mixture was poured into water, extracted with ether (15 mL x 3), dried over Na2S04 and evaporated to get the azide (283 mg). The azide was then dissolved in i-BuOH (8 mL) and to the solution was added CuS04 (13 mg, 0.078 mmol), sodium ascorbate (31 mg, 0.156 mmol), H20 (8 mL) and propiolic acid (109 mg, 1.56 mmol) and the mixture was sealed and stirred at room temperature overnight. The resulting suspension was poured into NaHCC"3 solution, and extracted with ether (15 mL x 2) and the ethereal solution was discarded. The aqueous phase was acidified with IN H2S04 and extracted with EtOAc (15 mL x 3), and the combined organic phase dried over Na2S04 and evaporated to dryness to obtain the final acid (217 mg, 55% yield) as a white solid. 1H NMR (400 MHz, DMSO- 6) δ 13.13 (bs, 1 H), 8.69 (s, 1 H), 7.36 (s, 1 H), 7.20 (s, 2 H), 5.71 (s, 2 H), 2.30 (s,3 H); 13C NMR (125 MHz, DMSO- 6) δ 161.6, 140.5, 139.6, 132.4, 130.6, 129.9, 129.7, 129.3, 128.4, 50.6, 20.3; HRMS (TOF-ESI) calcd for CiiHi0ClN3O2Na[M+Na]+: 274.0359, found: 274.0354.

Reference： [1]Zhao, Jinbo; Zhao, Huiping; Hall, Jessica A.; Brown, Douglas; Brandes, Eileen; Bazzill, Joseph; Grogan, Patrick T.; Subramanian, Chitra; Vielhauer, George; Cohen, Mark S.; Blagg, Brian S. J. [MedChemComm, 2014, vol. 5, # 9, p. 1317 - 1323]
[2]Current Patent Assignee: UNIVERSITY OF KANSAS - WO2015/192099, 2015, A1 Location in patent: Page/Page column 61-62

18
[ 39652-31-8 ]
1-(bromomethyl)-2-chloro-4-methylbenzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With phosphorus tribromide In dichloromethane at 0℃;

19
[ 39652-31-8 ]
[ 50817-80-6 ]

Yield	Reaction Conditions	Operation in experiment
96%	With 2-Picolinic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; manganese (II) nitrate tetrahydrate; acetic acid at 25℃; for 3h;

Reference： [1]Lagerblom, Kalle; Lagerspets, Emi; Keskiväli, Juha; Cook, Chris; Ekholm, Filip; Parviainen, Arno; Repo, Timo [ChemCatChem, 2017, vol. 9, # 20, p. 3880 - 3887]

20
[ 39652-31-8 ]
4-chloro-1-methoxy-2,6-dimethylindane [ No CAS ]
syn-4-chloro-2,6-dimethylindan-1-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: thionyl chloride / dichloromethane / 5 - 20 °C 2.1: sodium ethanolate / 0.25 h 2.2: 2 h / Reflux 3.1: aluminum (III) chloride / dichloromethane / 5 - 20 °C 4.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0 - 20 °C 5.1: potassium hydroxide / dimethyl sulfoxide / 5 h / 20 °C

Reference： [1]Current Patent Assignee: Borealis (in: OMV Group); OMV AKTIENGESELLSCHAFT - WO2018/91684, 2018, A1

21
[ 39652-31-8 ]
5-(benzenesulfonylcarbamoyl)-3-(2-chloro-4-methylbenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine [ No CAS ]

Reference： [1]Current Patent Assignee: ASTELLAS PHARMA INC. - US6348474, 2002, B1

22
[ 39652-31-8 ]
methyl 1-(2-chloro-4-methylbenzyl)-2-methyl-1H-imidazo[4,5-b]pyridine-5-carboxylate [ No CAS ]

Reference： [1]Current Patent Assignee: ASTELLAS PHARMA INC. - US6348474, 2002, B1

23
[ 39652-31-8 ]
methyl 3-(2-chloro-4-methylbenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate [ No CAS ]

Reference： [1]Current Patent Assignee: ASTELLAS PHARMA INC. - US6348474, 2002, B1

24
[ 39652-31-8 ]
3-(2-chloro-4-methylbenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid [ No CAS ]

Reference： [1]Current Patent Assignee: ASTELLAS PHARMA INC. - US6348474, 2002, B1

25
[ 39652-31-8 ]
tert-butyl 3-((2-chloro-4-methylbenzyl)oxy)azetidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 0 °C 2.2: 38 h / 0 - 20 °C

26
[ 39652-31-8 ]
3-((2-chloro-4-methylbenzyl)oxy)azetidine 4-methylbenzenesulfonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 0 °C 2.2: 38 h / 0 - 20 °C 3.1: ethyl acetate / 2 h / Reflux

27
[ 39652-31-8 ]
(2s,4s)-2-((3-((2-chloro-4-methylbenzyl)oxy)azetidin-1-yl)carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 0 °C 2.2: 38 h / 0 - 20 °C 3.1: ethyl acetate / 2 h / Reflux 4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

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Aryls

[ 34145-05-6 ]

(2,5-Dichlorophenyl)methanol

Similarity: 1.00

[ 1807180-27-3 ]

(2,5-Dichloro-3-methylphenyl)methanol

Similarity: 1.00

[ 39652-33-0 ]

(2,5-Dichloro-4-methylphenyl)methanol

Similarity: 1.00

[ 173310-45-7 ]

(2,6-Dichloro-4-methylphenyl)methanol

Similarity: 0.97

[ 1803779-26-1 ]

(2,3-Dichloro-4-methylphenyl)methanol

Similarity: 0.97

Chlorides

[ 34145-05-6 ]

(2,5-Dichlorophenyl)methanol

Similarity: 1.00

[ 1807180-27-3 ]

(2,5-Dichloro-3-methylphenyl)methanol

Similarity: 1.00

[ 39652-33-0 ]

(2,5-Dichloro-4-methylphenyl)methanol

Similarity: 1.00

[ 173310-45-7 ]

(2,6-Dichloro-4-methylphenyl)methanol

Similarity: 0.97

[ 1803779-26-1 ]

(2,3-Dichloro-4-methylphenyl)methanol

Similarity: 0.97

Alcohols

[ 34145-05-6 ]

(2,5-Dichlorophenyl)methanol

Similarity: 1.00

[ 1807180-27-3 ]

(2,5-Dichloro-3-methylphenyl)methanol

Similarity: 1.00

[ 39652-33-0 ]

(2,5-Dichloro-4-methylphenyl)methanol

Similarity: 1.00

[ 173310-45-7 ]

(2,6-Dichloro-4-methylphenyl)methanol

Similarity: 0.97

[ 1803779-26-1 ]

(2,3-Dichloro-4-methylphenyl)methanol

Similarity: 0.97

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 39652-31-8 ] {[proInfo.proName]}

Quality Control of [ 39652-31-8 ]

Related Doc. of [ 39652-31-8 ]

Product Details of [ 39652-31-8 ]

Safety of [ 39652-31-8 ]

Application In Synthesis of [ 39652-31-8 ]

[ 39652-31-8 ] Synthesis Path-Upstream 1~1

[ 39652-31-8 ] Synthesis Path-Downstream 1~27

Related Functional Groups of [ 39652-31-8 ]

Aryls

Chlorides

Alcohols

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 39652-31-8 ]