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Chemical Structure| 39885-57-9 Chemical Structure| 39885-57-9

Structure of 39885-57-9

Chemical Structure| 39885-57-9

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Product Details of [ 39885-57-9 ]

CAS No. :39885-57-9
Formula : C5H8ClNO2
M.W : 149.58
SMILES Code : O=C(Cl)N1COCCC1
MDL No. :MFCD18814181

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Application In Synthesis of [ 39885-57-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 39885-57-9 ]

[ 39885-57-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 39885-57-9 ]
  • [ 436-77-1 ]
  • 7-O-(1,3-oxazinane-3-carboxyl) fangchinoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With dmap; In dichloromethane; at 0 - 20℃;Inert atmosphere; General procedure: Acyl chloride (0.18 mmol, 1.1 eq) was added at 0 C to a solution of <strong>[436-77-1]fangchinoline</strong> (100 mg, 0.16 mmol) and DMAP (0.032 mmol, 0.2eq) in 2 mL dry CH2Cl2 under argon and stirred for 2-4 h. The reaction mixture was quenched with a saturated aqueous solution of sodium bicarbonate and extracted three times with CH2Cl2. The combined organic phase was dried over anhydrous magnesium sulfate before vacuum suction filtration. The removal of the solventin vacuo afforded the crude product, which was chromatographied on silica gel (CH2Cl2/MeOH, 50/1 v/v, 0.1% TEA) to provide the pureproduct 1a-1e, 2a-2g, 3a-3e and 4a-4h.
 

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