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Chemical Structure| 40232-88-0
Chemical Structure| 40232-88-0
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Product Details of [ 40232-88-0 ]

CAS No. :40232-88-0 MDL No. :N/A
Formula : C14H14O3 Boiling Point : -
Linear Structure Formula :- InChI Key :ATQAGTXPLZDYGP-UHFFFAOYSA-N
M.W : 230.26 Pubchem ID :562687
Synonyms :

Safety of [ 40232-88-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 40232-88-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 40232-88-0 ]
  • Downstream synthetic route of [ 40232-88-0 ]

[ 40232-88-0 ] Synthesis Path-Upstream   1~5

  • 1
  • [ 40232-88-0 ]
  • [ 13330-65-9 ]
Reference: [1] Magnetic Resonance in Chemistry, 1990, vol. 28, # 11, p. 973 - 978
  • 2
  • [ 2426-87-1 ]
  • [ 40232-88-0 ]
YieldReaction ConditionsOperation in experiment
74%
Stage #1: With 3-chloro-benzenecarboperoxoic acid In dichloromethane; water at 0℃; for 7.5 h; Inert atmosphere
Stage #2: at 20℃; for 1 h; Inert atmosphere
Under an argon atmosphere, m-chloroperbenzoic acid (contains ca 30percent water, purity >65percent, 41.7 g, ca. 157 mmol) was addedportionwise to a solution of S6 (25.3 g, 105 mmol) in dichloromethane (160 mL) at 0 °C.After stirring for 7.5 h, the reaction mixture was quenched with saturated aqueousNaHCO3. The mixture was diluted with water and the organic layer was separated. The aqueouslayer was extracted with dichloromethane. The combined extracts were washed with saturated aqueous NaHCO3, water, and brine, dried over Na2SO4, and evaporated. The residue was dissolvedin methanol (300 mL) and K2CO3 (72.3 g, 523 mmol) was added portionwise to the solution atroom temperature. After stirring for 1 h, the mixture was evaporated under reduced pressure. Waterwas added to the residue and the product was extracted with diethyl ether. The extract was washedwith water and brine, dried over Na2SO4, and evaporated. The residue was recrystallized fromdiethyl ether-hexane to give S7 as pale yellow granules (14.7 g, 61percent). The mother liquor from theabove recrystallization was evaporated and the residue was chromatographed over silica gel 60N (hexane–ethyl acetate = 3:1) to give an additional S7 as pale yellow solid (3.14 g, 13percent). The totalyield of S7 was 17.8 g (74percent).
Reference: [1] Tetrahedron Letters, 2007, vol. 48, # 12, p. 2139 - 2141
[2] Organic Letters, 2009, vol. 11, # 11, p. 2353 - 2356
[3] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 3, p. 283 - 286
[4] Synthetic Communications, 2008, vol. 38, # 5, p. 784 - 788
[5] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 24, p. 6563 - 6580
[6] European Journal of Organic Chemistry, 2014, vol. 2014, # 15, p. 3170 - 3181
[7] Journal of the Chemical Society, 1960, p. 1491 - 1498
[8] Magnetic Resonance in Chemistry, 1990, vol. 28, # 11, p. 973 - 978
[9] Chemical and Pharmaceutical Bulletin, 1983, vol. 31, # 9, p. 3024 - 3038
[10] Tetrahedron, 2005, vol. 61, # 42, p. 10061 - 10072
[11] Synthesis, 1989, # 3, p. 167 - 172
[12] Patent: US5064861, 1991, A,
[13] Helvetica Chimica Acta, 2011, vol. 94, # 2, p. 185 - 198
  • 3
  • [ 868856-34-2 ]
  • [ 40232-88-0 ]
Reference: [1] Helvetica Chimica Acta, 2011, vol. 94, # 2, p. 185 - 198
[2] Tetrahedron, 2005, vol. 61, # 42, p. 10061 - 10072
[3] Synthesis, 1989, # 3, p. 167 - 172
[4] Tetrahedron Letters, 2007, vol. 48, # 50, p. 8918 - 8921
  • 4
  • [ 121-33-5 ]
  • [ 40232-88-0 ]
Reference: [1] Tetrahedron Letters, 2007, vol. 48, # 12, p. 2139 - 2141
[2] Helvetica Chimica Acta, 2011, vol. 94, # 2, p. 185 - 198
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 15, p. 3170 - 3181
[4] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 24, p. 6563 - 6580
  • 5
  • [ 100-39-0 ]
  • [ 40232-88-0 ]
Reference: [1] Helvetica Chimica Acta, 2011, vol. 94, # 2, p. 185 - 198
[2] European Journal of Organic Chemistry, 2014, vol. 2014, # 15, p. 3170 - 3181
[3] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 24, p. 6563 - 6580
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