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Chemical Structure| 40483-63-4 Chemical Structure| 40483-63-4

Structure of 40483-63-4

Chemical Structure| 40483-63-4

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Product Details of [ 40483-63-4 ]

CAS No. :40483-63-4
Formula : C7H9ClN2O2
M.W : 188.61
SMILES Code : NNC1=CC=C(OCO2)C2=C1.[H]Cl
MDL No. :MFCD12031970

Safety of [ 40483-63-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 40483-63-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 40483-63-4 ]

[ 40483-63-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2620-45-3 ]
  • [ 40483-63-4 ]
YieldReaction ConditionsOperation in experiment
32% Example 4b (see general route 4, step H, M and K):6-methyl-5H-[l,3]dioxolo[4,5-f| indole[00290] A room temperature solution of benzo[d][l,3]dioxol-5-amine hydrochloride(25.0 g, 144 mmol) in concentrated 12M aqueous hydrochloric acid solution (60 mL) was stirred for two hours, after which, it was cooled to 0 C to which a solution of sodium nitrite(11.5 g, 167 mmol), in water (50 mL), was added, dropwise over 45 minutes, with internal temperature monitoring such that the reaction temperature does not warm above 5 C. After stirring for one hour at 0 C, the reaction mixture was poured slowly into a 0 C pre-made solution of tin(II) chloride dihydrate (136 g, 605 mmol) in concentrated 12M aqueous hydrochloric acid solution (125 mL). The reaction mixture was allowed to warm up to room temperature, after which it was stored in the freezer overnight (12 hours), leading to the formation of a precipitate. This dark brown solid was successively washed with water (2 x 100 mL) and diethyl ether (3 x 100 mL), and dried to afford benzo[d][l,3]dioxol-5-ylhydrazine hydrochloride (8.60 g, 46.1 mmol, 32% yield) as a dark brown solid. 1H NMR (400 MHz, CD3OD) delta (ppm): 6.79 (d, 1H), 6.63 (d, 1H), 6.50 (dd, 1H), 6.06 (s, 1H), 5.94 (s, 2H).
 

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