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Chemical Structure| 40492-92-0 Chemical Structure| 40492-92-0

Structure of 40492-92-0

Chemical Structure| 40492-92-0

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Product Details of [ 40492-92-0 ]

CAS No. :40492-92-0
Formula : C15H14O3
M.W : 242.27
SMILES Code : O=C(O)CCC1=CC=CC=C1OC2=CC=CC=C2
MDL No. :MFCD05663814

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Application In Synthesis of [ 40492-92-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 40492-92-0 ]

[ 40492-92-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 108-86-1 ]
  • [ 301346-12-3 ]
  • [ 495-78-3 ]
  • [ 40492-92-0 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; potassium carbonate; In methanol; hexane; acetone; Step A. 3-(2-Phenyloxyphenyl)propionic acid A mixture of <strong>[495-78-3]3-(2-hydroxyphenyl)propionic acid</strong> (0.57 g, 3.4 mmol), phenylbromide (0.4 ml, 3.37 mmol), and K2CO3 (2.5 g) in acetone (10 ml) was stirred at room temperature for 2 days. The mixture was diluted with 1:1 hexane/EtOAc (100 ml), washed with water and brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by chromatography (5:1 then 4:1 hexane/EtOAc) to yield phenyl 3-(2-phenyloxyphenyl)propionate (0.45 g, 1.30 mmol, 77%). A mixture of phenyl 3-(2-phenyloxyphenyl)propionate (0.45 g, 1.30 mmol), 2N NaOH (20 ml) and MeOH (10 ml) was stirred at room temperature overnight, which was then neutralized to pH~2 with concentrated HCl and extracted with EtOAc (100 ml). The organic phase was washed with brine and dried over sodium sulfate and concentrated in vacuo to yield 3-(2-phenyloxyphenyl)propionic acid as an oil. This was used for next step without further purification.
 

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