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Chemical Structure| 407640-11-3 Chemical Structure| 407640-11-3

Structure of 407640-11-3

Chemical Structure| 407640-11-3

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Product Details of [ 407640-11-3 ]

CAS No. :407640-11-3
Formula : C12H16Cl2N2O
M.W : 275.17
SMILES Code : NC[C@H]1CN(CC2=CC=C(Cl)C(Cl)=C2)CCO1

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Application In Synthesis of [ 407640-11-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 407640-11-3 ]

[ 407640-11-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 407640-11-3 ]
  • [ 154775-43-6 ]
  • [ 407640-41-9 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; for 16h; Example 26 A solution of 4- (2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (J. Med. Chem. (1998), 41 (14), 2492-2502) (0.462g) in N, N-dimethylformamide (4ml) was treated with N, N-diisopropylethylamine (0. 627 ml) and 0- (7- azabenzotriazol-1-yl)-N, N, N', N'-tetramethylammonium hexafluorophosphate (0.684g) followed by Description 5 (0.495g), and the mixture stirred at room temperature for 16 hours. The solution was concentrated to remove most of the solvent, dichloromethane (25moi) was added and this solution washed successively with saturated aqueous sodium hydrogen carbonate (2 x 25ml), dilute aqueous sodium chloride (25moi) and saturated aqueous sodium chloride (25ml). The solution was concentrated in vacuo and purified by chromatography using a Biotage silica gel cartridge, eluting with 80-100% ethyl acetate/cyclohexane followed by 1 % methanol/ethyl acetate. Appropriate fractions were combined and evaporated to give the title compound (0.485g) as a clear oil. LC-MS: Rt 2.89 min, Mass Spectrum m/z 514 [MH+]
 

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