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Chemical Structure| 40862-32-6 Chemical Structure| 40862-32-6

Structure of 40862-32-6

Chemical Structure| 40862-32-6

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Product Details of [ 40862-32-6 ]

CAS No. :40862-32-6
Formula : C10H10FIO
M.W : 292.09
SMILES Code : O=C(C1=CC=C(F)C=C1)CCCI
MDL No. :MFCD25963265

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Application In Synthesis of [ 40862-32-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 40862-32-6 ]

[ 40862-32-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 313368-85-3 ]
  • [ 40862-32-6 ]
  • [ 313368-91-1 ]
YieldReaction ConditionsOperation in experiment
84% With caesium carbonate; In acetonitrile; at 20℃; for 24h; 0.459 g (2.0 mmol) formula (II) compound is dissolved in 15 ml acetonitrile, then, to this, 1.303 g (4.0 mmol) caesium carbonate and 0.876 g (3.0 mmol) 4-iodo-4'-fluoro butyrophenone is added. The reaction mixture is stirred for 24 hours at room temperature. Then it is filtered and evaporated. The evaporation residue is dissolved in 20 ml dichlorom ethane and then extracted with 10 ml water, than with 10 ml saturated NaCl solution. The organic phase is dried on Na2S04, filtered and evaporated. The 1.06 g raw product obtained is cleaned on silica gel with flash chromatography using CfTCb-MeOH as eluent. 0.66 g (84%) formula (I) compound is obtained (light brown oil).
 

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