Home Cart 0 Sign in  

[ CAS No. 40926-73-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 40926-73-6
Chemical Structure| 40926-73-6
Structure of 40926-73-6 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 40926-73-6 ]

Related Doc. of [ 40926-73-6 ]

Alternatived Products of [ 40926-73-6 ]

Product Details of [ 40926-73-6 ]

CAS No. :40926-73-6 MDL No. :MFCD02223230
Formula : C9H9ClO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 200.62 Pubchem ID :-
Synonyms :

Safety of [ 40926-73-6 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 40926-73-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 40926-73-6 ]

[ 40926-73-6 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 1878-85-9 ]
  • [ 40926-73-6 ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride
With thionyl chloride Heating;
With thionyl chloride In tetrahydrofuran
With thionyl chloride for 0.5h; Heating;
With thionyl chloride for 2h; Reflux;
With dmap; thionyl chloride In dichloromethane for 2h; Reflux;
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 1h; Inert atmosphere;
With thionyl chloride; N,N-dimethyl-formamide In tetrahydrofuran at 50℃; for 5h; General procedure for the synthesis of HY-1a-HY-1f General procedure: A mixture of aryloxyl acid (5a-f) (10 mmol), thionyl chloride(15 mmol), tetrahydrofuran (50 ml) and dimethylformamide(1 ml) was stirred at 50 C for 5 h. Then tetrahydrofuran and thionylchloride were removed in vacuo. Yellow liquid (6a-f) obtainedand pyridine (2.5 ml) were then added to a solution of 10 (10 mmolin 25 ml tetrahydrofuran). The solution was stirred at 50 C for 3 h.When the reaction was completed, the solution was poured intohydrochloric acid (1 mol/L) and extracted with CH2Cl2(20 ml 3). The combined organic phase was washed with brine(20 ml 3), dried over Na2SO4, concentrated to afford yellow solid.Purification by silica gel column chromatography (PE:EA = 15:1) yielded the isoflavone amide derivatives HY-1a-HY-1f
With oxalyl dichloride In dichloromethane at 0 - 20℃; for 1h; General procedure: To a 0 °C stirring solution of substituted aryloxyacetic acid (4a-f, 5.4mmol) in anhydrous dichloromethane (50 mL) was slowly added oxalyl chloride (8 mmol) dropwise. After the reagent addition was complete, the ice bath was removed and the solution was allowed to stand at room temperature for 1 h. The solvent was removed under vacuum to obtain corresponding acyl chloride 5a-f sufficiently pure to be used directly in the next step of the reaction. To a stirred solution of corresponding 1-(substitutedbenzhydryl)piperazine (9a-d, 8mmol), triethylamine (6.8 mL) in dry acetone (30 mL) was slowly added acyl chloride 5a-f, dissolved in anhydrous acetone (30 mL). The mixture was stirred at room temperature for 16h and filtered off. The filtrate was evaporated and purified by column chromatography with AcOEt/petroleum ether (2/1) to give diphenylmethyl-substituted aryloxy acetylpiperazine analogs 10a-s, yield of33-84%.
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 12h;
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;

Reference: [1]Fridman [Zhurnal Obshchei Khimii, 1954, vol. 24, p. 642,645; engl. Ausg. S. 651, 654] Lin, Whei Oh; de Souza, Maria C. Bastos Viera; Altoe, Antonio P.; Alt, Helmut G. [Monatshefte fur Chemie, 1983, vol. 114, p. 359 - 364]
[2]Ernest,I. et al. [Collection of Czechoslovak Chemical Communications, 1963, vol. 28, p. 1022 - 1030]
[3]CONTI [Bollettino Chimico Farmaceutico, 1961, vol. 100, p. 572 - 575]
[4]Pekala, Elzbieta; Gajewczyk, Leonard; Marona, Henryk [Acta Poloniae Pharmaceutica, 1994, vol. 51, # 4-5, p. 339 - 342]
[5]Location in patent: experimental part Yu, Zhiyi; Shi, Guanying; Sun, Qiu; Jin, Hong; Teng, Yun; Tao, Ke; Zhou, Guoping; Liu, Wei; Wen, Fang; Hou, Taiping [European Journal of Medicinal Chemistry, 2009, vol. 44, # 11, p. 4726 - 4733]
[6]Location in patent: experimental part Jimenez, Fabiola; Cruz, Maria Del Carmen; Zuniga, Clara; Martinez, Maria A.; Chamorro, German; Diaz, Francisco; Tamariz, Joaquin [Medicinal Chemistry Research, 2010, vol. 19, # 1, p. 33 - 57]
[7]Buendia, Julien; Mottweiler, Jakob; Bolm, Carsten [Chemistry - A European Journal, 2011, vol. 17, # 49, p. 13877 - 13882]
[8]Wang, Wenbin; He, Yi; Xu, Pei; You, Qidong; Xiao, Hong; Xiang, Hua [Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4428 - 4433]
[9]Zhong, Yan; Xu, Yi; Zhang, Ai-Xia; Li, Xiao-Feng; Xu, Zhao-Ying; Li, Ping; Wu, Bin [Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 10, p. 2526 - 2530]
[10]Lei, Kang; Li, Pan; Yang, Xue-Fang; Wang, Shi-Ben; Wang, Xue-Kun; Hua, Xue-Wen; Sun, Bin; Ji, Lu-Sha; Xu, Xiao-Hua [Journal of Agricultural and Food Chemistry, 2019, vol. 67, # 37, p. 10489 - 10497]
[11]Li, Shangda; Wang, Hang; Weng, Yunxiang; Li, Gang [Angewandte Chemie - International Edition, 2019, vol. 58, # 51, p. 18502 - 18507][Angew. Chem., 2019, vol. 58, # 131, p. 18673 - 18678,6]
  • 2
  • [ 40926-73-6 ]
  • [ 75057-62-4 ]
  • [ 75057-56-6 ]
  • 3
  • [ 40926-73-6 ]
  • [ 20776-54-9 ]
  • [ 75057-57-7 ]
  • 4
  • [ 112-34-5 ]
  • [ 40926-73-6 ]
  • Butoxyethoxyethyl o-methoxyphenoxyacetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
69.01% In chloroform for 12h; Heating;
  • 5
  • [ 40926-73-6 ]
  • [ 5456-63-3 ]
  • N-((1R,2R)-2-Hydroxy-cyclohexyl)-2-(2-methoxy-phenoxy)-acetamide [ No CAS ]
Same Skeleton Products
Historical Records