Alternatived Products of [ 41009-85-2 ]
Product Details of [ 41009-85-2 ]
CAS No. : | 41009-85-2 |
MDL No. : | MFCD09926774 |
Formula : |
C12H18O2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | OTILCBBQTIFAGJ-UHFFFAOYSA-N |
M.W : |
194.27
|
Pubchem ID : | 13661944 |
Synonyms : |
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Application In Synthesis of [ 41009-85-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 41009-85-2 ]
- 1
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[ 41009-85-2 ]
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[ 41009-86-3 ]
Yield | Reaction Conditions | Operation in experiment |
80% |
With dibromotriphenylphosphorane In dichloromethane at 20℃; for 24h; |
5.D Step D
To a stirred solution of the intermediate from Step C (2.5 g, 12.8 mmol) was added dibromotriphenylphosphorane (21.7 g, 51.5 mmol) in DCM (200 mL). The resulting mixture was stirred at ambient temperature overnight (24 hours) and then the mixture was concentrated under reduced pressure and hexane (200 mL) was added to the residue. The heterogeneous mixture was stirred rapidly for 30 minutes and then the hexane layer was decanted from the insoluble material. The organic layer was washed with water (2×100 mL), saturated NaCl (1×100 mL), dried over magnesium sulfate, filtered and the solvent removed under reduced pressure to afford 3.14 g of the title intermediate (80% yield), which was used without further purification. |
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With hydrogen bromide |
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With sulfuric acid; sodium bromide |
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Reference:
[1]Current Patent Assignee: THERAVANCE BIOPHARMA, INC. - US2005/203167, 2005, A1
Location in patent: Page/Page column 21
[2]Effenberger,F.; Kurtz,W.
[Chemische Berichte, 1973, vol. 106, p. 511 - 524]
Ruzicka; Buijs; Stoll
[Helvetica Chimica Acta, 1932, vol. 15, p. 1220,1224]
[3]Schimelpfenig,C.W.
[Journal of Organic Chemistry, 1975, vol. 40, p. 1493 - 1494]