Name: 41014-93-1|(S)-2-hydroxyvaleric acid|97%
Brand: Ambeed
SKU: A136261
Price: 22.0 USD
Availability: InStock
Rating: 93 (40 reviews)

1
[ 908094-01-9 ]
[ 41014-93-1 ]
[ 95912-79-1 ]

Yield	Reaction Conditions	Operation in experiment
90%
	With diethyl ether
	In tetrahydrofuran at 0℃; Yield given;

	In diethyl ether
0.34 g	In diethyl ether for 0.166667h; Ambient temperature;

Reference： [1]Pansare, Sunil V.; Ravi, R. Gnana [Tetrahedron, 1998, vol. 54, # 48, p. 14549 - 14564]
[2]Lemieux; Giguere [Canadian Journal of Chemistry, 1951, vol. 29, p. 678,688]
[3]Bur; Luyten; Wynn; Provencher; Jones; Gold; Friesen; Clarke; Holbrook [Canadian Journal of Chemistry, 1989, vol. 67, # 6, p. 1065 - 1070]
[4]Kim,M.J.; Whitesides,G.M. [Journal of the American Chemical Society, 1988, vol. 110, p. 2959]
[5]Seebach, Dieter; Maestro, Miguel A.; Sefkow, Michael; Adam, Geo; Hintermann, Samuel; Neidlein, Axel [Liebigs Annalen der Chemie, 1994, # 7, p. 701 - 718]

2
[ 6600-40-4 ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
97%	With sulfuric acid; NaNO₂ In water monomer at 0 - 20℃;
82%	With sulfuric acid; NaNO₂ In water monomer at 0 - 5℃; for 1h;
	With hydrogenchloride; acetic acid; NaNO₂

	With hydrogenchloride; silver(I) nitrite
	With hydrogenchloride; acetic acid; NaNO₂ at 0 - 20℃;
	With sulfuric acid; NaNO₂ In water monomer at 0℃; for 2h;

Reference： [1]Fernández, Ariadna; Díaz, José Luis; García, Mónica; Rodríguez-Escrich, Sergi; Lorente, Adriana; Enrech, Raquel; Dordal, Albert; Portillo-Salido, Enrique; Porras, Mónica; Fernández, Begoña; Reinoso, Raquel F.; Vela, José Miguel; Almansa, Carmen [ACS Medicinal Chemistry Letters, 2021, vol. 12, # 11, p. 1802 - 1809]
[2]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]
[3]Winitz et al. [Journal of the American Chemical Society, 1956, vol. 78, p. 2423,2428]
[4]Baker; Meister [Journal of the American Chemical Society, 1951, vol. 73, p. 1336]
[5]Nakamura, Kaoru; Inoue, Kiyoko; Ushio, Kazutoshi; Oka, Shinzaburo; Ohno, Atsuyoshi [Journal of Organic Chemistry, 1988, vol. 53, # 11, p. 2589 - 2593]
[6]Raddatz, Peter; Minck, Klaus-Otto; Rippmann, Friedrich; Schmitges, Claus-Jochen [Journal of Medicinal Chemistry, 1994, vol. 37, # 4, p. 486 - 497]

3
[ 41014-93-1 ]
[ 29117-54-2 ]

Yield	Reaction Conditions	Operation in experiment
	With lithium aluminium tetrahydride In diethyl ether

Reference： [1]Williams, David R.; Li, Jie [Tetrahedron Letters, 1994, vol. 35, # 29, p. 5113 - 5116]

4
[ 41014-93-1 ]
[ 29117-54-2 ]
[ 108340-61-0 ]

Yield	Reaction Conditions	Operation in experiment
66%	With lithium aluminium tetrahydride In diethyl ether 1.) 0 deg C, then 3 h rt.; Yields of byproduct given;

Reference： [1]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]

5
[ 41014-93-1 ]
[ 100-39-0 ]
(S)-(-)-benzyl 2-hydroxypentanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone for 24h; Heating;
	With potassium carbonate In N,N-dimethyl-formamide for 14h; Ambient temperature;

Reference： [1]Fuerstner, Alois; Bonnekessel, Melanie; Blank, Jarred T.; Radkowski, Karin; Seidel, Guenter; Lacombe, Fabrice; Gabor, Barbara; Mynott, Richard [Chemistry - A European Journal, 2007, vol. 13, # 31, p. 8762 - 8783]
[2]Raddatz, Peter; Minck, Klaus-Otto; Rippmann, Friedrich; Schmitges, Claus-Jochen [Journal of Medicinal Chemistry, 1994, vol. 37, # 4, p. 486 - 497]

6
[ 13022-83-8 ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
94%	With potassium hydroxide; mercaptoethyl alcohol; sodium formate; 2-amino-2-hydroxymethyl-1,3-propanediol In water for 72h;

Reference： [1]Kim,M.J.; Whitesides,G.M. [Journal of the American Chemical Society, 1988, vol. 110, p. 2959]

7
(S)-2-Hydroxy-pentanoic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(naphthalene-1-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester [ No CAS ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
89%	With lithium hydroxide In tetrahydrofuran; water for 1h; Ambient temperature;

Reference： [1]Xiang, Yi Bin; Snow, Ken; Belley, Michel [Journal of Organic Chemistry, 1993, vol. 58, # 5, p. 993 - 994]

8
[ 1821-02-9 ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
89%	With NAD; hydrogen In hydrogenchloride for 35h; Ambient temperature;
	With fructose 1,6-bisphosphate trisodium; nicotinamide adenine dinucleotide red. form; R₁₇₁Y mutant In water at 25℃; other mutant enzyme;
	Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 0 °C 1.2: tetrahydrofuran / 12 h / 20 °C 2.1: H₂O₂; aq. NaOH / tetrahydrofuran

	Multi-step reaction with 6 steps 1: Cl₂CHOCH₃ / CH₂Cl₂ / 1.) room temperature, 20 min, 2.) 50-55 deg C, 30 min 2: Et₃N, DMAP / CH₂Cl₂ / 6 h / Ambient temperature 3: 92 percent / TFA / CH₂Cl₂ / 78 h / Heating 4: 99 percent / H₂ / Pd/C / ethyl acetate / 2585.7 Torr 5: 59 percent / Na, liquid NH₃ / tetrahydrofuran / 0.01 h 6: 1M H₂SO₄ / Heating
	Multi-step reaction with 6 steps 1: Cl₂CHOCH₃ / CH₂Cl₂ / 1.) room temperature, 20 min, 2.) 50-55 deg C, 30 min 2: Et₃N, DMAP / CH₂Cl₂ / 6 h / Ambient temperature 3: TiCl₄ / -40 °C 4: 99 percent / H₂ / Pd/C / ethyl acetate / 2585.7 Torr 5: 59 percent / Na, liquid NH₃ / tetrahydrofuran / 0.01 h 6: 1M H₂SO₄ / Heating

Reference： [1]Bur; Luyten; Wynn; Provencher; Jones; Gold; Friesen; Clarke; Holbrook [Canadian Journal of Chemistry, 1989, vol. 67, # 6, p. 1065 - 1070]
[2]Kallwass, Helmut K.W.; Hogan, James K.; Macfarlane, Emma L.A.; Martichonok, Valeri; Partis, Wendy; Kay, Cyril M.; Gold, Marvin; Bryan Jones [Journal of the American Chemical Society, 1992, vol. 114, # 27, p. 10704 - 10710]
[3]Ramachandran, P. Veeraraghavan; Pitre, Sangeeta; Brown, Herbert C. [Journal of Organic Chemistry, 2002, vol. 67, # 15, p. 5315 - 5319]
[4]Pansare, Sunil V.; Ravi, R.Gnana; Jain, Rajendra P. [Journal of Organic Chemistry, 1998, vol. 63, # 12, p. 4120 - 4124]
[5]Pansare, Sunil V.; Ravi, R.Gnana; Jain, Rajendra P. [Journal of Organic Chemistry, 1998, vol. 63, # 12, p. 4120 - 4124]

9
[ 157733-17-0 ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
65%	With hydrogenchloride In tetrahydrofuran for 24h; Ambient temperature;

Reference： [1]Seebach, Dieter; Maestro, Miguel A.; Sefkow, Michael; Adam, Geo; Hintermann, Samuel; Neidlein, Axel [Liebigs Annalen der Chemie, 1994, # 7, p. 701 - 718]

10
[ 219598-66-0 ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
74%	With sulfuric acid In water at 90℃; for 0.5h;

Reference： [1]Pansare, Sunil V.; Ravi, R. Gnana [Tetrahedron, 1998, vol. 54, # 48, p. 14549 - 14564]

11
[ 1821-02-9 ]
[ 24809-83-4 ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
	With diisopinocampheylborane In tetrahydrofuran at 20℃; for 6h; Title compound not separated from byproducts.;

Reference： [1]Veeraraghavan Ramachandran; Brown, Herbert C.; Pitre, Sangeeta [Organic Letters, 2001, vol. 3, # 1, p. 17 - 18]

12
5-Propyl-2-((1R,2S,3R,5R)-2,6,6-trimethyl-bicyclo[3.1.1]hept-3-yl)-[1,3,2]dioxaborolan-4-one [ No CAS ]
[ 24809-83-4 ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide; dihydrogen peroxide In tetrahydrofuran Title compound not separated from byproducts.;

Reference： [1]Ramachandran, P. Veeraraghavan; Pitre, Sangeeta; Brown, Herbert C. [Journal of Organic Chemistry, 2002, vol. 67, # 15, p. 5315 - 5319]

13
[ 41014-93-1 ]
[ 76513-69-4 ]
[ 526198-28-7 ]

Yield	Reaction Conditions	Operation in experiment
70%	With N-ethyl-N,N-diisopropylamine

Reference： [1]Content, Stephane; Dutton, Christopher J.; Roberts, Lee [Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 321 - 325]

14
[ 41014-93-1 ]
[ 589-15-1 ]
(S)-2-(4-Bromo-benzyloxy)-pentanoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2-(S)-hydroxyvaleric acid With sodium hydride In N,N-dimethyl-formamide Stage #2: 1-bromomethyl-4-bromobenzene In N,N-dimethyl-formamide at 20℃;

Reference： [1]Pinelli, Alessandra; Godio, Cristina; Laghezza, Antonio; Mitro, Nico; Fracchiolla, Giuseppe; Tortorella, Vincenzo; Lavecchia, Antonio; Novellino, Ettore; Fruchart, Jean-Charles; Staels, Bart; Crestani, Maurizio; Loiodice, Fulvio [Journal of Medicinal Chemistry, 2005, vol. 48, # 17, p. 5509 - 5519]

15
[ 41014-93-1 ]
[ 905835-75-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: NaH / dimethylformamide 1.2: dimethylformamide / 20 °C 2.1: diethyl ether

Reference： [1]Pinelli, Alessandra; Godio, Cristina; Laghezza, Antonio; Mitro, Nico; Fracchiolla, Giuseppe; Tortorella, Vincenzo; Lavecchia, Antonio; Novellino, Ettore; Fruchart, Jean-Charles; Staels, Bart; Crestani, Maurizio; Loiodice, Fulvio [Journal of Medicinal Chemistry, 2005, vol. 48, # 17, p. 5509 - 5519]

16
[ 41014-93-1 ]
[ 905835-85-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: NaH / dimethylformamide 1.2: dimethylformamide / 20 °C 2.1: diethyl ether 3.1: 70 percent / K₂CO₃; Pd(PPh₃)4 / toluene / 7 h / 80 °C

Reference： [1]Pinelli, Alessandra; Godio, Cristina; Laghezza, Antonio; Mitro, Nico; Fracchiolla, Giuseppe; Tortorella, Vincenzo; Lavecchia, Antonio; Novellino, Ettore; Fruchart, Jean-Charles; Staels, Bart; Crestani, Maurizio; Loiodice, Fulvio [Journal of Medicinal Chemistry, 2005, vol. 48, # 17, p. 5509 - 5519]

17
[ 41014-93-1 ]
(S)-2-(4'-Chloro-biphenyl-4-ylmethoxy)-pentanoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: NaH / dimethylformamide 1.2: dimethylformamide / 20 °C 2.1: diethyl ether 3.1: 70 percent / K₂CO₃; Pd(PPh₃)4 / toluene / 7 h / 80 °C 4.1: 50 percent / aq. NaOH / tetrahydrofuran / 20 °C

Reference： [1]Pinelli, Alessandra; Godio, Cristina; Laghezza, Antonio; Mitro, Nico; Fracchiolla, Giuseppe; Tortorella, Vincenzo; Lavecchia, Antonio; Novellino, Ettore; Fruchart, Jean-Charles; Staels, Bart; Crestani, Maurizio; Loiodice, Fulvio [Journal of Medicinal Chemistry, 2005, vol. 48, # 17, p. 5509 - 5519]

18
[ 41014-93-1 ]
[ 526198-16-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 70 percent / Huning's base 2: 95 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide; DMAP / CH₂Cl₂ 3: 90 percent / MgBr₂*Et₂O / -20 °C

Reference： [1]Content, Stephane; Dutton, Christopher J.; Roberts, Lee [Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 321 - 325]

19
[ 41014-93-1 ]
[ 526198-29-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 70 percent / Huning's base 2: 95 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide; DMAP / CH₂Cl₂

Reference： [1]Content, Stephane; Dutton, Christopher J.; Roberts, Lee [Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 321 - 325]

20
[ 41014-93-1 ]
(Z)-(2S,6S,8S,9R)-6,8,9-Trihydroxy-12-methyl-2-propyl-1-oxa-4-aza-cyclooctacos-12-ene-3,28-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: 70 percent / Huning's base 2: 95 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide; DMAP / CH₂Cl₂ 3: 90 percent / MgBr₂*Et₂O / -20 °C 4: 95 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide / CH₂Cl₂ 5: 55 percent / [(CF₃)2MeCO]2Mo(=CHCMe₂Ph)=N-2,6-(iPr)2C₆H₃ / benzene / 15 h / 60 °C 6: aq. HClO₄ / methanol; tetrahydrofuran

Reference： [1]Content, Stephane; Dutton, Christopher J.; Roberts, Lee [Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 321 - 325]

21
[ 41014-93-1 ]
(E)-(2S,6S,8S,9R)-6,8,9-Trihydroxy-12-methyl-2-propyl-1-oxa-4-aza-cyclooctacos-12-ene-3,28-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: 70 percent / Huning's base 2: 95 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide; DMAP / CH₂Cl₂ 3: 90 percent / MgBr₂*Et₂O / -20 °C 4: 95 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide / CH₂Cl₂ 5: 55 percent / [(CF₃)2MeCO]2Mo(=CHCMe₂Ph)=N-2,6-(iPr)2C₆H₃ / benzene / 15 h / 60 °C 6: aq. HClO₄ / methanol; tetrahydrofuran

Reference： [1]Content, Stephane; Dutton, Christopher J.; Roberts, Lee [Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 321 - 325]

22
[ 41014-93-1 ]
(E)-(3aS,5S,9S,29aR)-5-Methoxymethoxy-2,2,27-trimethyl-9-propyl-3a,4,5,6,7,12,13,14,15,16,17,18,19,20,21,22,23,24,25,28,29,29a-docosahydro-1,3,10-trioxa-7-aza-cyclopentacyclooctacosene-8,11-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: 70 percent / Huning's base 2: 95 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide; DMAP / CH₂Cl₂ 3: 90 percent / MgBr₂*Et₂O / -20 °C 4: 95 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide / CH₂Cl₂ 5: 55 percent / [(CF₃)2MeCO]2Mo(=CHCMe₂Ph)=N-2,6-(iPr)2C₆H₃ / benzene / 15 h / 60 °C

Reference： [1]Content, Stephane; Dutton, Christopher J.; Roberts, Lee [Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 321 - 325]

23
[ 41014-93-1 ]
(E)-(2S,6R,7S,8R,9S,10R)-6,7,8,9,10-Pentahydroxy-2-propyl-1-oxa-4-aza-cyclooctacos-12-ene-3,28-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: 70 percent / Huning's base 2: 95 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide; DMAP / CH₂Cl₂ 3: 90 percent / MgBr₂*Et₂O / -20 °C 4: 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide / CH₂Cl₂ / 1 h / 20 °C 5: 90 percent / (Cy₃P)2Cl₂Ru=CHPh / CH₂Cl₂ / 18 h / 20 °C 6: 64 percent / aq. AcOH / 60 °C

Reference： [1]Content, Stephane; Dutton, Christopher J.; Roberts, Lee [Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 321 - 325]

24
[ 207223-17-4 ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 62 percent / Et₃N, DMAP / CH₂Cl₂ / 6 h / Ambient temperature 2: 87 percent / HCl / tetrahydrofuran; H₂O / 3 h / Ambient temperature 3: KBH₄ / methanol / 10 h / 0 °C 4: 74 percent / H₂SO₄ / H₂O / 0.5 h / 90 °C
	Multi-step reaction with 5 steps 1: Et₃N, DMAP / CH₂Cl₂ / 6 h / Ambient temperature 2: 92 percent / TFA / CH₂Cl₂ / 78 h / Heating 3: 99 percent / H₂ / Pd/C / ethyl acetate / 2585.7 Torr 4: 59 percent / Na, liquid NH₃ / tetrahydrofuran / 0.01 h 5: 1M H₂SO₄ / Heating
	Multi-step reaction with 5 steps 1: Et₃N, DMAP / CH₂Cl₂ / 6 h / Ambient temperature 2: TiCl₄ / -40 °C 3: 99 percent / H₂ / Pd/C / ethyl acetate / 2585.7 Torr 4: 59 percent / Na, liquid NH₃ / tetrahydrofuran / 0.01 h 5: 1M H₂SO₄ / Heating

Reference： [1]Pansare, Sunil V.; Ravi, R. Gnana [Tetrahedron, 1998, vol. 54, # 48, p. 14549 - 14564]
[2]Pansare, Sunil V.; Ravi, R.Gnana; Jain, Rajendra P. [Journal of Organic Chemistry, 1998, vol. 63, # 12, p. 4120 - 4124]
[3]Pansare, Sunil V.; Ravi, R.Gnana; Jain, Rajendra P. [Journal of Organic Chemistry, 1998, vol. 63, # 12, p. 4120 - 4124]

25
[ 207223-31-2 ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 99 percent / H₂ / Pd/C / ethyl acetate / 2585.7 Torr 2: 59 percent / Na, liquid NH₃ / tetrahydrofuran / 0.01 h 3: 1M H₂SO₄ / Heating

Reference： [1]Pansare, Sunil V.; Ravi, R.Gnana; Jain, Rajendra P. [Journal of Organic Chemistry, 1998, vol. 63, # 12, p. 4120 - 4124]

26
[ 207223-39-0 ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 59 percent / Na, liquid NH₃ / tetrahydrofuran / 0.01 h 2: 1M H₂SO₄ / Heating

Reference： [1]Pansare, Sunil V.; Ravi, R.Gnana; Jain, Rajendra P. [Journal of Organic Chemistry, 1998, vol. 63, # 12, p. 4120 - 4124]

27
[ 207223-21-0 ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 92 percent / TFA / CH₂Cl₂ / 78 h / Heating 2: 99 percent / H₂ / Pd/C / ethyl acetate / 2585.7 Torr 3: 59 percent / Na, liquid NH₃ / tetrahydrofuran / 0.01 h 4: 1M H₂SO₄ / Heating
	Multi-step reaction with 4 steps 1: TiCl₄ / -40 °C 2: 99 percent / H₂ / Pd/C / ethyl acetate / 2585.7 Torr 3: 59 percent / Na, liquid NH₃ / tetrahydrofuran / 0.01 h 4: 1M H₂SO₄ / Heating

Reference： [1]Pansare, Sunil V.; Ravi, R.Gnana; Jain, Rajendra P. [Journal of Organic Chemistry, 1998, vol. 63, # 12, p. 4120 - 4124]
[2]Pansare, Sunil V.; Ravi, R.Gnana; Jain, Rajendra P. [Journal of Organic Chemistry, 1998, vol. 63, # 12, p. 4120 - 4124]

28
[ 41014-93-1 ]
(2S)-2-(((ethyloxy)(3-phenylpropyl)phosphoryl)oxy)pentanoic acid benzyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: K₂CO₃ / dimethylformamide / 14 h / Ambient temperature 2: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 0 °C 3: NaIO₄ / dioxane; H₂O / 3 h / Ambient temperature 4: K₂CO₃ / dimethylformamide / 14 h / Ambient temperature

Reference： [1]Raddatz, Peter; Minck, Klaus-Otto; Rippmann, Friedrich; Schmitges, Claus-Jochen [Journal of Medicinal Chemistry, 1994, vol. 37, # 4, p. 486 - 497]

29
[ 41014-93-1 ]
(S)-2-Oxo-2-(3-phenyl-propyl)-5-propyl-2λ⁵-[1,3,2]dioxaphospholan-4-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: K₂CO₃ / dimethylformamide / 14 h / Ambient temperature 2: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 0 °C 3: NaIO₄ / dioxane; H₂O / 3 h / Ambient temperature 4: 96 percent / 1 N LiOH / dioxane / 1 h / Ambient temperature 5: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 0 °C

Reference： [1]Raddatz, Peter; Minck, Klaus-Otto; Rippmann, Friedrich; Schmitges, Claus-Jochen [Journal of Medicinal Chemistry, 1994, vol. 37, # 4, p. 486 - 497]

30
[ 41014-93-1 ]
[ 152830-20-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: K₂CO₃ / dimethylformamide / 14 h / Ambient temperature 2: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 0 °C 3: NaIO₄ / dioxane; H₂O / 3 h / Ambient temperature 4: 96 percent / 1 N LiOH / dioxane / 1 h / Ambient temperature

Reference： [1]Raddatz, Peter; Minck, Klaus-Otto; Rippmann, Friedrich; Schmitges, Claus-Jochen [Journal of Medicinal Chemistry, 1994, vol. 37, # 4, p. 486 - 497]

31
[ 41014-93-1 ]
(S)-2-(3-Phenyl-propylphosphinoyloxy)-pentanoic acid benzyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: K₂CO₃ / dimethylformamide / 14 h / Ambient temperature 2: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 0 °C

Reference： [1]Raddatz, Peter; Minck, Klaus-Otto; Rippmann, Friedrich; Schmitges, Claus-Jochen [Journal of Medicinal Chemistry, 1994, vol. 37, # 4, p. 486 - 497]

32
[ 41014-93-1 ]
[ 152830-12-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: K₂CO₃ / dimethylformamide / 14 h / Ambient temperature 2: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 0 °C 3: NaIO₄ / dioxane; H₂O / 3 h / Ambient temperature

Reference： [1]Raddatz, Peter; Minck, Klaus-Otto; Rippmann, Friedrich; Schmitges, Claus-Jochen [Journal of Medicinal Chemistry, 1994, vol. 37, # 4, p. 486 - 497]

33
[ 41014-93-1 ]
(2R,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-2-methyl-5-((2S)-2-(((3-phenylpropyl)hydroxyphosphoryl)oxy)pentanamido)hexanamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: K₂CO₃ / dimethylformamide / 14 h / Ambient temperature 2: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 0 °C 3: NaIO₄ / dioxane; H₂O / 3 h / Ambient temperature 4: 96 percent / 1 N LiOH / dioxane / 1 h / Ambient temperature 5: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 0 °C 6: Et₃N / tetrahydrofuran / 0 °C

Reference： [1]Raddatz, Peter; Minck, Klaus-Otto; Rippmann, Friedrich; Schmitges, Claus-Jochen [Journal of Medicinal Chemistry, 1994, vol. 37, # 4, p. 486 - 497]

34
[ 41014-93-1 ]
[ 113686-29-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: diethyl ether 2: 3-(dimethylamino)propylamine / CCl₄; benzene
	Multi-step reaction with 2 steps 1: tetrahydrofuran / 0 °C 2: 4-dimethylaminopyridine

Reference： [1]Kim,M.J.; Whitesides,G.M. [Journal of the American Chemical Society, 1988, vol. 110, p. 2959]
[2]Bur; Luyten; Wynn; Provencher; Jones; Gold; Friesen; Clarke; Holbrook [Canadian Journal of Chemistry, 1989, vol. 67, # 6, p. 1065 - 1070]

35
[ 41014-93-1 ]
(2S,3R,5S)-5-Propyl-2-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan-3-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 16 steps 1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C 3: aq. ethanol / 19 h / Heating 5: 83 percent / imidazole / dimethylformamide / 15 h / Ambient temperature 6: 95 percent / lithium borohydride, lithium triethylborohydride / diethyl ether; tetrahydrofuran / 3 h / Heating 7: pyridine / 3 h / 0 - 5 °C 8: 88 percent / NaI, NaHCO₃ / acetone / 2 h / Heating 9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 10: sodium acetate, bromine / 2 h / Ambient temperature 11: NaOH / methanol / 1 h / Ambient temperature 12: triethylamine / tetrahydrofuran / 2 h / 0 °C 13: DBU / benzene / 2 h / Heating 14: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature 15: 1.) m-CPBA; 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, then rt.; 2.) 30 min, rt. 16: n-BuLi / tetrahydrofuran; hexane / 1 h / -60 °C
	Multi-step reaction with 16 steps 1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C 3: aq. ethanol / 19 h / Heating 5: 83 percent / imidazole / dimethylformamide / 15 h / Ambient temperature 6: 95 percent / lithium borohydride, lithium triethylborohydride / diethyl ether; tetrahydrofuran / 3 h / Heating 7: pyridine / 3 h / 0 - 5 °C 8: 88 percent / NaI, NaHCO₃ / acetone / 2 h / Heating 9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 10: sodium acetate, bromine / 2 h / Ambient temperature 11: NaOH / methanol / 1 h / Ambient temperature 12: triethylamine / tetrahydrofuran / 2 h / 0 °C 13: DBU / benzene / 2 h / Heating 14: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature 15: 1.) m-CPBA; 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, then rt.; 2.) 30 min, rt. 16: n-BuLi, CO₂ / tetrahydrofuran; hexane / 1 h / -60 °C

Reference： [1]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]
[2]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]

36
[ 41014-93-1 ]
(2S,3aS,9bS)-6-Hydroxy-7,8-dimethoxy-2-propyl-2,3,3a,9b-tetrahydro-furo[3,2-c]isochromen-5-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 18 steps 1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C 3: aq. ethanol / 19 h / Heating 5: 83 percent / imidazole / dimethylformamide / 15 h / Ambient temperature 6: 95 percent / lithium borohydride, lithium triethylborohydride / diethyl ether; tetrahydrofuran / 3 h / Heating 7: pyridine / 3 h / 0 - 5 °C 8: 88 percent / NaI, NaHCO₃ / acetone / 2 h / Heating 9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 10: sodium acetate, bromine / 2 h / Ambient temperature 11: NaOH / methanol / 1 h / Ambient temperature 12: triethylamine / tetrahydrofuran / 2 h / 0 °C 13: DBU / benzene / 2 h / Heating 14: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature 15: 1.) m-CPBA; 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, then rt.; 2.) 30 min, rt. 16: n-BuLi / tetrahydrofuran; hexane / 1 h / -60 °C 17: Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 3 h / Ambient temperature 18: boron tribromide / CH₂Cl₂ / 0.5 h / -20 °C
	Multi-step reaction with 18 steps 1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C 3: aq. ethanol / 19 h / Heating 5: 83 percent / imidazole / dimethylformamide / 15 h / Ambient temperature 6: 95 percent / lithium borohydride, lithium triethylborohydride / diethyl ether; tetrahydrofuran / 3 h / Heating 7: pyridine / 3 h / 0 - 5 °C 8: 88 percent / NaI, NaHCO₃ / acetone / 2 h / Heating 9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 10: sodium acetate, bromine / 2 h / Ambient temperature 11: NaOH / methanol / 1 h / Ambient temperature 12: triethylamine / tetrahydrofuran / 2 h / 0 °C 13: DBU / benzene / 2 h / Heating 14: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature 15: 1.) m-CPBA; 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, then rt.; 2.) 30 min, rt. 16: n-BuLi, CO₂ / tetrahydrofuran; hexane / 1 h / -60 °C 17: Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 3 h / Ambient temperature 18: boron tribromide / CH₂Cl₂ / 0.5 h / -20 °C

Reference： [1]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]
[2]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]

37
[ 41014-93-1 ]
(2S,3aR,9bR)-2,3,3a,9b-tetrahydro-6-hydroxy-7,8-dimethoxy-2-propyl-5H-furo(3,2-c)⁽²⁾benzopyran-5-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 18 steps 1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C 3: aq. ethanol / 19 h / Heating 5: 83 percent / imidazole / dimethylformamide / 15 h / Ambient temperature 6: 95 percent / lithium borohydride, lithium triethylborohydride / diethyl ether; tetrahydrofuran / 3 h / Heating 7: pyridine / 3 h / 0 - 5 °C 8: 88 percent / NaI, NaHCO₃ / acetone / 2 h / Heating 9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 10: sodium acetate, bromine / 2 h / Ambient temperature 11: NaOH / methanol / 1 h / Ambient temperature 12: triethylamine / tetrahydrofuran / 2 h / 0 °C 13: DBU / benzene / 2 h / Heating 14: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature 15: 1.) m-CPBA; 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, then rt.; 2.) 30 min, rt. 16: n-BuLi / tetrahydrofuran; hexane / 1 h / -60 °C 17: Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 3 h / Ambient temperature 18: 71 percent / boron tribromide / CH₂Cl₂ / 0.5 h / -20 °C
	Multi-step reaction with 18 steps 1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C 3: aq. ethanol / 19 h / Heating 5: 83 percent / imidazole / dimethylformamide / 15 h / Ambient temperature 6: 95 percent / lithium borohydride, lithium triethylborohydride / diethyl ether; tetrahydrofuran / 3 h / Heating 7: pyridine / 3 h / 0 - 5 °C 8: 88 percent / NaI, NaHCO₃ / acetone / 2 h / Heating 9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 10: sodium acetate, bromine / 2 h / Ambient temperature 11: NaOH / methanol / 1 h / Ambient temperature 12: triethylamine / tetrahydrofuran / 2 h / 0 °C 13: DBU / benzene / 2 h / Heating 14: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature 15: 1.) m-CPBA; 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, then rt.; 2.) 30 min, rt. 16: n-BuLi, CO₂ / tetrahydrofuran; hexane / 1 h / -60 °C 17: Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 3 h / Ambient temperature 18: 71 percent / boron tribromide / CH₂Cl₂ / 0.5 h / -20 °C

Reference： [1]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]
[2]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]

38
[ 41014-93-1 ]
(2S,3aS,9bS)-2,3,3a,9b,-tetrahydro-6,7,8-trimethoxy-2-propyl-5H-furol(3,2-c)⁽²⁾benzopyran-5-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 17 steps 1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C 3: aq. ethanol / 19 h / Heating 5: 83 percent / imidazole / dimethylformamide / 15 h / Ambient temperature 6: 95 percent / lithium borohydride, lithium triethylborohydride / diethyl ether; tetrahydrofuran / 3 h / Heating 7: pyridine / 3 h / 0 - 5 °C 8: 88 percent / NaI, NaHCO₃ / acetone / 2 h / Heating 9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 10: sodium acetate, bromine / 2 h / Ambient temperature 11: NaOH / methanol / 1 h / Ambient temperature 12: triethylamine / tetrahydrofuran / 2 h / 0 °C 13: DBU / benzene / 2 h / Heating 14: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature 15: 1.) m-CPBA; 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, then rt.; 2.) 30 min, rt. 16: n-BuLi / tetrahydrofuran; hexane / 1 h / -60 °C 17: Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 3 h / Ambient temperature
	Multi-step reaction with 17 steps 1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C 3: aq. ethanol / 19 h / Heating 5: 83 percent / imidazole / dimethylformamide / 15 h / Ambient temperature 6: 95 percent / lithium borohydride, lithium triethylborohydride / diethyl ether; tetrahydrofuran / 3 h / Heating 7: pyridine / 3 h / 0 - 5 °C 8: 88 percent / NaI, NaHCO₃ / acetone / 2 h / Heating 9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 10: sodium acetate, bromine / 2 h / Ambient temperature 11: NaOH / methanol / 1 h / Ambient temperature 12: triethylamine / tetrahydrofuran / 2 h / 0 °C 13: DBU / benzene / 2 h / Heating 14: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature 15: 1.) m-CPBA; 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, then rt.; 2.) 30 min, rt. 16: n-BuLi, CO₂ / tetrahydrofuran; hexane / 1 h / -60 °C 17: Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 3 h / Ambient temperature

Reference： [1]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]
[2]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]

39
[ 41014-93-1 ]
[ 30270-61-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 17 steps 1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C 3: aq. ethanol / 19 h / Heating 5: 83 percent / imidazole / dimethylformamide / 15 h / Ambient temperature 6: 95 percent / lithium borohydride, lithium triethylborohydride / diethyl ether; tetrahydrofuran / 3 h / Heating 7: pyridine / 3 h / 0 - 5 °C 8: 88 percent / NaI, NaHCO₃ / acetone / 2 h / Heating 9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 10: sodium acetate, bromine / 2 h / Ambient temperature 11: NaOH / methanol / 1 h / Ambient temperature 12: triethylamine / tetrahydrofuran / 2 h / 0 °C 13: DBU / benzene / 2 h / Heating 14: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature 15: 1.) m-CPBA; 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, then rt.; 2.) 30 min, rt. 16: n-BuLi / tetrahydrofuran; hexane / 1 h / -60 °C 17: Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 3 h / Ambient temperature
	Multi-step reaction with 17 steps 1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C 3: aq. ethanol / 19 h / Heating 5: 83 percent / imidazole / dimethylformamide / 15 h / Ambient temperature 6: 95 percent / lithium borohydride, lithium triethylborohydride / diethyl ether; tetrahydrofuran / 3 h / Heating 7: pyridine / 3 h / 0 - 5 °C 8: 88 percent / NaI, NaHCO₃ / acetone / 2 h / Heating 9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 10: sodium acetate, bromine / 2 h / Ambient temperature 11: NaOH / methanol / 1 h / Ambient temperature 12: triethylamine / tetrahydrofuran / 2 h / 0 °C 13: DBU / benzene / 2 h / Heating 14: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature 15: 1.) m-CPBA; 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, then rt.; 2.) 30 min, rt. 16: n-BuLi, CO₂ / tetrahydrofuran; hexane / 1 h / -60 °C 17: Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 3 h / Ambient temperature

Reference： [1]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]
[2]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]

40
[ 41014-93-1 ]
6-((2S,3R,5S)-3-Hydroxy-5-propyl-tetrahydro-furan-2-yl)-2,3,4-trimethoxy-benzoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 16 steps 1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C 3: aq. ethanol / 19 h / Heating 5: 83 percent / imidazole / dimethylformamide / 15 h / Ambient temperature 6: 95 percent / lithium borohydride, lithium triethylborohydride / diethyl ether; tetrahydrofuran / 3 h / Heating 7: pyridine / 3 h / 0 - 5 °C 8: 88 percent / NaI, NaHCO₃ / acetone / 2 h / Heating 9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 10: sodium acetate, bromine / 2 h / Ambient temperature 11: NaOH / methanol / 1 h / Ambient temperature 12: triethylamine / tetrahydrofuran / 2 h / 0 °C 13: DBU / benzene / 2 h / Heating 14: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature 15: 1.) m-CPBA; 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, then rt.; 2.) 30 min, rt. 16: n-BuLi / tetrahydrofuran; hexane / 1 h / -60 °C
	Multi-step reaction with 16 steps 1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C 3: aq. ethanol / 19 h / Heating 5: 83 percent / imidazole / dimethylformamide / 15 h / Ambient temperature 6: 95 percent / lithium borohydride, lithium triethylborohydride / diethyl ether; tetrahydrofuran / 3 h / Heating 7: pyridine / 3 h / 0 - 5 °C 8: 88 percent / NaI, NaHCO₃ / acetone / 2 h / Heating 9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 10: sodium acetate, bromine / 2 h / Ambient temperature 11: NaOH / methanol / 1 h / Ambient temperature 12: triethylamine / tetrahydrofuran / 2 h / 0 °C 13: DBU / benzene / 2 h / Heating 14: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature 15: 1.) m-CPBA; 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, then rt.; 2.) 30 min, rt. 16: n-BuLi, CO₂ / tetrahydrofuran; hexane / 1 h / -60 °C

Reference： [1]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]
[2]Mori, Kenji; Takaishi, Hideo [Tetrahedron, 1989, vol. 45, # 6, p. 1639 - 1646]

41
[ 123-91-1 ]
[ 41014-93-1 ]

Yield	Reaction Conditions	Operation in experiment
		1 61 g of S-α-hydroxyvaleric acid are obtained in the form of a light-yellow oil which still contains approximately 20% dioxan.

Reference： [1]Current Patent Assignee: NOVARTIS AG; Novartis (w/o Sandoz) - US4940799, 1990, A

42
[ 41014-93-1 ]
ethyl 5-ethyl-1-(6-(3-((3-ethyl-4-(piperidin-4-yl)phenyl)amino)-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl)-1H-pyrazole-4-carboxylate [ No CAS ]
ethyl 5-ethyl-1-(6-((3S)-3-((3-ethyl-4-(1-((2S)-2-hydroxypentanoyl)piperidin-4-yl)phenyl)amino)-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl)-1H-pyrazole-4-carboxylate [ No CAS ]
ethyl 5-ethyl-1-(6-((3R)-3-((3-ethyl-4-(1-((2S)-2-hydroxypentanoyl)piperidin-4-yl)phenyl)amino)-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl)-1H-pyrazole-4-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide for 2h;	49.49.A.a; 49.49.A.b Example 49-A. b). Ethyl 5-ethyl-1 -(6-(3-((3-ethyl-4-(1 -((S)-2-hydroxypentanoyl)piperidin-4- yl)phenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-1 H-pyrazole-4-carboxylate (diastereomer-1) and ethyl 5-ethyl-1 -(6-(3-((3-ethyl-4-(1 -((S)-2-hydroxypentanoyl)piperidin- 4-yl)phenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-1 H-pyrazole-4-carboxylate (diastereomer-2). General procedure: Example 45-C. a) (±)-Ethyl 1 -(6-(3-((4-(1 -(cyclobutanecarbonyl)piperidin-4-yl)-2- methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4- carboxylate; HATU (94 mg, 0.246 mmol) was added to a solution of (±)-ethyl 5-methyl-1 -(6-(3- ((2-methyl-4-(piperidin-4-yl)phenyl)amino)-2,3-dihydro 4-carboxylate (120 mg, 0.224 mmol), DIPEA (1 17 μΙ_, 0.672 mmol), and cyclobutanecarboxylic acid (18.32 μΙ_, 0.220 mmol) in DMF (2.2 ml_). The mixture was then stirred for 2 h, and then diluted with H20/brine (ca. 1/1) and EtOAc. The bi-layer was then separated. The aqueous layer was then extracted with EtOAc. The combined organic layers were washed with brine, dried, and concentrated to firnish the title compound. MS (ESI+) m/z 618.5 (M+H).; Example 49. Example 49-A. a). Ethyl 5-ethyl-1 -(6-(3-((3-ethyl-4-(1 -((S)-2-hydroxypentanoyl)piperidin-4- yl)phenyl)amino)-2,3-dihydro- H-pyrazole-4-carboxylate; The title compound was synthesized analogously to the preparation of ethyl 5-ethyl-1 -(6- (3-((3-ethyl-4-(1 -((S)-2-hydroxypropanoyl)piperidin-4-yl)phenyl)amino)-2,3-dihydro-1 H-inden-4- yl)pyridin-2-yl)-1 H-pyrazole-4-carboxylate (Example 48-B. a)) but using (S)-2-hydroxypentanoic acid in the place of L-(+)-lactic acid. MS (ESI+) m/z 664.4 (M+H).; Resolution of the diastereomers of ethyl 5-ethyl-1 -(6-(3-((3-ethyl-4-(1 -((S)-2- hydroxypentanoyl)piperidin-4-yl)phenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-1 H- pyrazole-4-carboxylate was achieved by chiral HPLC using CHIRALPAK IA column with 65% hexane with 0.1 % DEA in EtOH to give ethyl 5-ethyl-1 -(6-(3-((3-ethyl-4-(1 -((S)-2- hydroxypentanoyl)piperidin-4-yl)phenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-1 H- pyrazole-4-carboxylate (diastereomer-1) (tr = 7.5 min) and ethyl 5-ethyl-1 -(6-(3-((3-ethyl-4-(1 - ((S)-2-hydroxypentanoyl)piperidin-4-yl)phenyl)amino)-2,3-dihydro-1H-inden-4-y 1H-pyrazole-4-carboxylate (diastereomer-2) (tr = 10.2 min).

Reference： [1]Current Patent Assignee: ESSITY AKTIEBOLAG (PUBL); Novartis (w/o Sandoz); NOVARTIS AG - WO2016/1875, 2016, A1 Location in patent: Page/Page column 169; 177; 178-179; 180-181

43
[ 617-31-2 ]
[ 41014-93-1 ]
[ 1821-02-9 ]

Yield	Reaction Conditions	Operation in experiment
> 99 % ee	With D-lactate oxidase from Gluconobacter oxydans 621H; oxygen; catalase In aq. buffer at 30℃; for 12h; Resolution of racemate; Enzymatic reaction; enantioselective reaction;

Reference： [1]Sheng, Binbin; Xu, Jing; Ge, Yongsheng; Zhang, Shuo; Wang, Danqi; Gao, Chao; Ma, Cuiqing; Xu, Ping [ChemCatChem, 2016, vol. 8, # 16, p. 2630 - 2633]

44
[ 41014-93-1 ]
[ 1263377-68-9 ]
(S)-5-bromo-N-ethyl-2-(2-hydroxypentanamido)benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%	Stage #1: (2S)-2-hydroxypentanoic acid With O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluoro-phosphate In N,N-dimethyl-formamide for 0.166667h; Inert atmosphere; Stage #2: 2-amino-5-bromo-N-ethylbenzamide With triethylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;

Reference： [1]Fernández, Ariadna; Díaz, José Luis; García, Mónica; Rodríguez-Escrich, Sergi; Lorente, Adriana; Enrech, Raquel; Dordal, Albert; Portillo-Salido, Enrique; Porras, Mónica; Fernández, Begoña; Reinoso, Raquel F.; Vela, José Miguel; Almansa, Carmen [ACS Medicinal Chemistry Letters, 2021, vol. 12, # 11, p. 1802 - 1809]

45
[ 41014-93-1 ]
6-bromo-3-ethyl-2-((R)-1-((S)-3-methylpiperazin-1-yl)butyl)quinazolin-4(3H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluoro-phosphate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: iodine / dichloromethane / 0.33 h 2.2: 16 h / 50 °C 3.1: N,N,N-tributylbutan-1-aminium fluoride / tetrahydrofuran / 0.5 h / 0 °C 4.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / dichloromethane / 2 h / -78 °C 4.2: 2 h / -78 - 20 °C

Reference： [1]Fernández, Ariadna; Díaz, José Luis; García, Mónica; Rodríguez-Escrich, Sergi; Lorente, Adriana; Enrech, Raquel; Dordal, Albert; Portillo-Salido, Enrique; Porras, Mónica; Fernández, Begoña; Reinoso, Raquel F.; Vela, José Miguel; Almansa, Carmen [ACS Medicinal Chemistry Letters, 2021, vol. 12, # 11, p. 1802 - 1809]

46
[ 41014-93-1 ]
6-bromo-3-ethyl-2-((R)-1-((S)-3-ethylpiperazin-1-yl)butyl)quinazolin-4(3H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluoro-phosphate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: iodine / dichloromethane / 0.33 h 2.2: 16 h / 50 °C 3.1: N,N,N-tributylbutan-1-aminium fluoride / tetrahydrofuran / 0.5 h / 0 °C 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / -78 °C 5.1: acetonitrile / 24 h / 80 °C

Reference： [1]Fernández, Ariadna; Díaz, José Luis; García, Mónica; Rodríguez-Escrich, Sergi; Lorente, Adriana; Enrech, Raquel; Dordal, Albert; Portillo-Salido, Enrique; Porras, Mónica; Fernández, Begoña; Reinoso, Raquel F.; Vela, José Miguel; Almansa, Carmen [ACS Medicinal Chemistry Letters, 2021, vol. 12, # 11, p. 1802 - 1809]

47
[ 41014-93-1 ]
(R)-6-bromo-2-(1-(3,3-dimethylpiperazin-1-yl)butyl)-3-ethylquinazolin-4(3H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluoro-phosphate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: iodine / dichloromethane / 0.33 h 2.2: 16 h / 50 °C 3.1: N,N,N-tributylbutan-1-aminium fluoride / tetrahydrofuran / 0.5 h / 0 °C 4.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / dichloromethane / 2 h / -78 °C 4.2: 2 h / -78 - 20 °C

Reference： [1]Fernández, Ariadna; Díaz, José Luis; García, Mónica; Rodríguez-Escrich, Sergi; Lorente, Adriana; Enrech, Raquel; Dordal, Albert; Portillo-Salido, Enrique; Porras, Mónica; Fernández, Begoña; Reinoso, Raquel F.; Vela, José Miguel; Almansa, Carmen [ACS Medicinal Chemistry Letters, 2021, vol. 12, # 11, p. 1802 - 1809]

48
[ 41014-93-1 ]
(S)-6-bromo-3-ethyl-2-(1-hydroxybutyl)quinazolin-4(3H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluoro-phosphate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: iodine / dichloromethane / 0.33 h 2.2: 16 h / 50 °C 3.1: N,N,N-tributylbutan-1-aminium fluoride / tetrahydrofuran / 0.5 h / 0 °C

Reference： [1]Fernández, Ariadna; Díaz, José Luis; García, Mónica; Rodríguez-Escrich, Sergi; Lorente, Adriana; Enrech, Raquel; Dordal, Albert; Portillo-Salido, Enrique; Porras, Mónica; Fernández, Begoña; Reinoso, Raquel F.; Vela, José Miguel; Almansa, Carmen [ACS Medicinal Chemistry Letters, 2021, vol. 12, # 11, p. 1802 - 1809]

49
[ 41014-93-1 ]
C₁₇H₂₇BrN₂O₃Si [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluoro-phosphate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: iodine / dichloromethane / 0.33 h 2.2: 16 h / 50 °C

Reference： [1]Fernández, Ariadna; Díaz, José Luis; García, Mónica; Rodríguez-Escrich, Sergi; Lorente, Adriana; Enrech, Raquel; Dordal, Albert; Portillo-Salido, Enrique; Porras, Mónica; Fernández, Begoña; Reinoso, Raquel F.; Vela, José Miguel; Almansa, Carmen [ACS Medicinal Chemistry Letters, 2021, vol. 12, # 11, p. 1802 - 1809]

50
[ 41014-93-1 ]
(S)-1-(6-bromo-3-ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)butyl methanesulfonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluoro-phosphate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: iodine / dichloromethane / 0.33 h 2.2: 16 h / 50 °C 3.1: N,N,N-tributylbutan-1-aminium fluoride / tetrahydrofuran / 0.5 h / 0 °C 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / -78 °C

Reference： [1]Fernández, Ariadna; Díaz, José Luis; García, Mónica; Rodríguez-Escrich, Sergi; Lorente, Adriana; Enrech, Raquel; Dordal, Albert; Portillo-Salido, Enrique; Porras, Mónica; Fernández, Begoña; Reinoso, Raquel F.; Vela, José Miguel; Almansa, Carmen [ACS Medicinal Chemistry Letters, 2021, vol. 12, # 11, p. 1802 - 1809]

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CAS No. :	41014-93-1	MDL No. :	MFCD11975325
Formula :	C₅H₁₀O₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	JRHWHSJDIILJAT-BYPYZUCNSA-N
M.W :	118.13	Pubchem ID :	6950703
Synonyms :

Num. heavy atoms :	8
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.8
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	2.0
Molar Refractivity :	29.08
TPSA :	57.53 Å²

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.7 cm/s

Log Po/w (iLOGP) :	1.11
Log Po/w (XLOGP3) :	0.45
Log Po/w (WLOGP) :	0.23
Log Po/w (MLOGP) :	0.01
Log Po/w (SILICOS-IT) :	-0.13
Consensus Log Po/w :	0.33

[ CAS No. 41014-93-1 ] {[proInfo.proName]}

Quality Control of [ 41014-93-1 ]

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Physicochemical Properties

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[ 41014-93-1 ] Synthesis Path-Downstream 1~50

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[ 41014-93-1 ]

Aliphatic Chain Hydrocarbons

Alcohols

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Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.56

Log S (ESOL) :	-0.66
Solubility :	26.0 mg/ml ; 0.22 mol/l
Class :	Very soluble
Log S (Ali) :	-1.23
Solubility :	7.02 mg/ml ; 0.0594 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	0.13
Solubility :	159.0 mg/ml ; 1.34 mol/l
Class :	Soluble

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.54

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338-P310	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

[ CAS No. 41014-93-1 ] {[proInfo.proName]}

Quality Control of [ 41014-93-1 ]

Related Doc. of [ 41014-93-1 ]

Product Details of [ 41014-93-1 ]

Calculated chemistry of [ 41014-93-1 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 41014-93-1 ]

Application In Synthesis of [ 41014-93-1 ]

[ 41014-93-1 ] Synthesis Path-Downstream 1~50

Related Functional Groups of [ 41014-93-1 ]

Aliphatic Chain Hydrocarbons

Alcohols

Carboxylic Acids

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 41014-93-1 ]